The Epidemiology of Sarcoma

Table 3 Summary of findings

Strong evidence of association	Cancer	Suggestive evidence of association	Cancer	No evidence of association	Cancer	Too little evidence to draw conclusions	Cancer
HIV/HHV8 Infections (A) [14, 15, 29, 30, 33, 34]	KS	Hernias (P) [38, 53, 62, 64]	ES	Menstrual and reproductive factors (A) [56]	STS	Birth weight (P) [41, 50, 60]	STS, MBT
Radiotherapy (secondary sarcomas) (AP) [6, 7, 9, 20, 21, 32, 46, 59]	STS, MBT	Adolescence growth & pubertal factors (P) [24, 28, 50, 55, 63, 71]	OS	DDT, asbestos, wood dust (A) [18, 45, 58]	STS, MBT	Birth order (P) [37, 57]	RS
		Occupation: job type/industry (A) [16, 19, 23]	STS, MBT	Flouride in drinking water (AP) [17, 36]	OS	Maternal age (P) [37, 40, 51, 57]	STS, RS
		Herbicides & chlorophenols (A) [8, 48, 58]	STS			Pregnancy medications (P) [39, 53, 60]	STS, ES, RS
		Place of residence, industrial emissions (A) [49, 72]	STS			Pregnancy conditions (P) [39, 53, 60]	STS
						History of infection: chicken pox & mumps (A) [34]	STS
						Parental occupation (P) [5, 10, 12, 53]	MBT
						Radium in drinking water (AP) [31, 35]	OS
						Ionizing radiation -low dose (A) [32]	MBT
						Tobacco, alcohol, & drug use (AP) [51, 53, 73–76]	STS, RS, KS, ES

STS = Soft tissue sarcoma, MBT = Malignant bone tumor, KS = Kaposi's sarcoma, OS = Osteosarcoma, ES = Ewing's sarcoma, CS = Chondrosarcoma, RS = Rhabdomyosarcoma.
(A) = Adult sarcomas, (P) = Pediatric sarcomas, (AP) = Adult & Pediatric sarcomas.

ISSN: 2045-3329