Table 4 A summary of sarcoma types from different transformation studies in mice

Osteosarcoma

Mouse BMMSCs

-

[4]

-

[6]

C-myc overexpression and Ink4a/Arf knockout

[16]

Mouse osteoblast precursors

Tp53, Rb double knockout

[56]

Mouse osteoblasts

Tp53 knockout

[57]

Tp53 and Rb double knockout [57]

Tp53 knockout

[17]

Leiomyosarcomas

Mouse AMSCs

Tp53 knockout

[14]

Tp53 knockout

[24]

Tp53 and Rb double knockout [8]

Mouse smooth muscle lineage cells

Pten knockout

[30]

“Fibrosarcoma”

Mouse BMMSCs

-

[58]

Aged mouse BMMSCs

-

[25]

Mouse AMSCs

P21 knockout, Tp53 heterozygous knockout

[24]

Pleomorphic rhabdomyosarcoma

Mouse skeletal muscle cells

K-ras overexpression and Tp53 knockout

[32]

K- ras overexpression and Tp53 heterozygous knockout [32]