Comprehensive analysis of published studies involving systemic treatment for chondrosarcoma of bone between 2000 and 2013
© van Maldegem et al.; licensee BioMed Central Ltd. 2014
Received: 10 July 2014
Accepted: 1 August 2014
Published: 12 August 2014
The majority of patients with chondrosarcoma of bone have an excellent overall survival after local therapy. However, in case of unresectable locally advanced or metastatic disease the outcome is poor and limited treatment options exist. Therefore we conducted a survey of clinical phase I or II trials and retrospective studies that described systemic therapy for chondrosarcoma patients.
Materials and methods
Using PubMed, clinicaltrials.gov, the Cochrane controlled trial register and American Society of Clinical Oncology (ASCO) abstracts a literature survey was conducted. From the identified items, data were collected by a systematic analysis. We limited our search to semi-recent studies published between 2000 and 2013 to include modern drugs, imaging techniques and disease evaluations.
A total of 31 studies were found which met the criteria: 9 phase I trials, 11 phase II and 8 retrospective studies. In these studies 855 chondrosarcoma patients were reported. The tested drugs were mostly non-cytotoxic, either alone or in combination with another non-cytotoxic agent or chemotherapy. Currently two phase I trials, one phase IB/II trial and three phase II trials are enrolling chondrosarcoma patients.
Because chondrosarcoma of bone is an orphan disease it is difficult to conduct clinical trials. The meagre outcome data for locally advanced or metastatic patients indicate that new treatment options are needed. For the phase I trials it is difficult to draw conclusions because of the low numbers of chondrosarcoma patients enrolled, and at different dose levels. Some phase II trials show promising results which support further research. Retrospective studies are encouraged as they could add to the limited data available. Efforts to increase the number of studies for this orphan disease are urgently needed.
KeywordsChondrosarcoma Systemic treatment Clinical trial
Chondrosarcoma (CS) is the second most common primary bone sarcoma in humans, but with an estimated incidence of 0.2 in 100.000 patients per year it is still a very rare disease. CS mostly affects adults between the age of 20 and 60. CS belong to a very diverse group of tumors having in common the production of cartilaginous matrix. Almost 90% of the CS are of the conventional subtype, but there are also the more rare subtypes with their own distinct histological and clinical features including clear cell, mesenchymal and dedifferentiated CS. The prognosis for patients with CS is very diverse with a very good prognosis for atypical cartilaginous tumour/CS grade I which are slow growing and do not metastasize and a poor prognosis for grade III CS which have a high risk, up to 70%, for local recurrence and metastasis[4, 5]. Currently the most commonly used treatment option for atypical cartilaginous tumour/CS grade I is curettage with local adjuvants which is usually enough to cure the patient. However, for grade II and grade III CS en bloc resection is required. If a patient has unresectable or metastasized disease the current treatment options are very limited. CS has always been considered to be chemotherapy and radiotherapy resistant and it was assumed that patients would not benefit from non-surgical treatment. However, new preclinical work and retrospective studies show that there may be a place for non-cytotoxic, chemo- and radiotherapy in the treatment of CS[6, 7]. In the last decades more knowledge has become available about the molecular background of the different CS subtypes (for review see[8–10]). Investigators have been trying to find new systemic treatment options for these patients through phase I and II clinical trials (no phase III studies were ever conducted). Because CS is such a rare disease, and high grade metastatic or unresectable disease is even more uncommon, the number of patients in these trials is however low and thereby it is difficult to give a clear answer to the question whether a new drug improves outcome or not. Here we report an overview of a survey we conducted on published and presented phase I and II clinical trials and retrospective studies on systemic therapy enrolling CS patients, published from 2000 until 2013. We also include the studies that are enrolling patients at this moment.
Material and methods
To collect phase I and II and retrospective studies which included CS patients we used the search machines PubMed, clinicaltrials.gov, the Cochrane controlled trial register and American Society of Clinical Oncology (ASCO) abstracts. For the search criteria we used the terms [chondrosarcoma] AND [phase I OR phase II OR retrospective] AND [clinical trial]. To check for missed articles we widened the search to [sarcoma] AND [phase I OR phase II] AND [clinical trial] and compared the results. When multiple reports from the same trial were published we only used the article with the longest follow up time. Publications were used if they 1) described results from an early phase clinical trial in which CS patients were included, either prospective or retrospective, 2) were written in English. The latest search was performed in December 2013. Studies on extraskeletal myxoid CS were excluded.
Data were collected from trials published between 2000 and 2013 to include modern drugs, imaging techniques and disease evaluations. Data extraction was done by one of the authors (A.v.M) and a systemic analysis was applied that is normally used for meta-analysis. From all reports author name, year of publication, number of patients, intervention and outcome data were noted.
Phase I trials included in the analysis showing the name of the author, year of publication, number of patients enrolled in the trial, the intervention that was tested and the outcome
No of patients
Outcome for CS patients
Serrone et al.
44 advanced sarcoma (2 CS)
Group A: IFOS short infusion + EPI
Group B: IFOS continuous infusion + EPI
Schwartz et al.
38 advanced solid tumors with 6 sarcoma with at least 1 CS
LY293111 (Leucotriene-B4 receptor antagonist)
Levine et al.
51 advanced malignancies with 7 sarcoma with at least 1 CS
Veglin (VEGF antisense oligodeoxynucleotide)
Lockhart et al.
18 advanced malignancies (1 CS)
MAC-321 (analogue of docetaxel)
Chawla et al.
20 advanced sarcoma (1 CS)
Rexin-G (tumor-targeted retrovector)
Group A: 2 times a week
Group B: 3 times a week
Camidge et al.
50 advanced malignancies with 11 sarcoma with at least 1 CS
PRO95780 (death receptor 5 antibody)
Herbst et al.
71 advanced malignancies with 9 sarcoma with at least 2 CS
rhApo2L/TRAIL (death receptor activator)
Cohort 1: dose escalation
Cohort 2: treated at MTD
Olmos et al.
29 advanced sarcoma (1 CS)
Figitumumab (IGF1R antibody)
Qeuk et al.
21 advanced solid tumors (1 CS)
Everolimus (mTOR inhibitor) and figitumumab (IGF1R antibody)
Stroppa et al.
8 advanced sarcoma (1 CS)
Doxorubicin + IFOS
Pacey et al.
25 advanced solid tumors with at least 1 CS
Alvespimycin (heat shock protein 90 inhibitor)
Phase II trials included in the analysis with the name of the author, year of publication, number of patients enrolled in the trial, the intervention that was tested and the outcome
No of patients
Outcome for CS patients
Merimsky et al.
18 advanced sarcoma (3 CS)
Skubitz et al.
47 advanced sarcoma (1 CS)
Nooij et al.
37 bone sarcoma (16 CS)
Doxorubicin + cisplatin
Group A: operable, non-metastatic (4 CS)
Group B: inoperable, metastatic (12 CS)
Maki et al.
145 advanced sarcoma (2 CS)
Sorafenib (multi-tyrosine kinase inhibitor)
Pacey et al.
26 advanced sarcoma (2 CS)
Sorafenib(multi-tyrosine kinase inhibitor)
Grignani et al.
26 advanced chondrosarcoma
Imatinib mesylate (c-kit/PDGFR inhibitor)
OS 11 months
Fox et al.
53 advanced sarcoma (25 CS)
Gemcitabine + docetaxel
Italiano et al.
40 advanced CS
GDC-0449/vismodegib (hedgehog inhibitor)
4 SD (of first 17 patients)
Schuetze et al.
49 advanced sarcoma (2 CS)
Sirolimus (mTOR inhibitor) + cyclophosphamide
Ha et al.
36 advanced sarcoma
Cetuximab (EGFR antibody)
Group A: EGFR+
Group B: EGFR- (1 CS)
Schwartz et al.
388 advanced sarcoma
Cixutumumab (IGF1R antibody) + temsirolimus (mTOR-inhibitor)
Group A: IGF-1R + soft tissue sarcoma
Group B: IGF-1R + bone sarcoma (20 CS)
Group C: IGF-1R- sarcoma (18 CS)
Retrospective trials included in the analysis showing the name of the author, year of publication, number of patients enrolled in the trial, the intervention that was tested and the outcome
Year of publication
No of patients
Intervention and number of patients
Outcome of systemic therapy
22 resectable dediff CS
Doxorubicin based chemotherapy + surgery
1/5 > 90% necrosis after preoperative chemo
5 preoperative chemotherapy and 6 postoperative, 11 no chemotherapy
5 year OS with chemotherapy 36%, without 0%
42 local or advanced dediff CS
5 year OS and median OS: with surgery 11.8% and 6.4 months
22 surgery and chemotherapy 5 other
With surgery and chemotherapy 4% and 8.4 months
102 local or advanced dediff central CS
Median survival 18 vs 23 months (not significant)
25 surgery + chemotherapy
9 palliative care
24 local or advanced mesenchymal CS
24 surgery of which:
10 year OS:
5 + RT
Surgical remission 27%
12 + chemotherapy
Non-surgical remission 0%
Complete surgical remission 10 year DFS:
With chemotherapy 76%, without 17%
266 local and 71 advanced dediff CS
5 year OS:
40 surgery + chemotherapy
With chemotherapy 33%, without 25% (p = 0.11)
Median OS: With chemotherapy 7 months, without 3 months (not significant)
14 local mesenchymal CS
12 Surgery + chemotherapy
10 year OS 64%
2 surgery + RT
9 advanced CS
Sirolimus + cyclophosphamide
PFS 15 months
98 advanced CS
Doxorubicin based chemotherapy
PFS 5.3 months
OS 19 months
Overview of the trials currently recruiting chondrosarcoma patients, showing the clinicaltrials.gov number, title of the study and the phase
Vaccine therapy with or without sirolimus in treating patients with NY-ESO-1 expressing solid tumors
Dasatinib and ipilimumab in treating patients with gastrointestinal stromal tumors or other sarcomas that cannot be removed by surgery or are metastatic
Vismodegib and gamma-secretase/notch signalling pathway inhibitor RO4929097 in treating patients with advanced or metastatic sarcoma
Study of pazopanib in the treatment of surgically unresectable or metastatic chondrosarcoma
Imatinib in patients with desmoid tumor and chondrosarcoma
Alisertib in treating patients with advanced or metastatic sarcoma
Not yet assigned
A phase 2, single arm, multi center trial evaluating the efficacy of the combination of sirolimus and cyclophosphamide in metastatic or unresectable myxoid liposarcoma and chondrosarcoma.
CS is a primary bone cancer that in most patients can be cured by local treatment alone. When tumors are unresectable, either because of locally advanced or metastatic disease, systemic treatment options are very limited due to the current view that non-surgical treatment options have no benefit. Currently for advanced CS patients the outcome is poor with an overall survival of less than two years[5, 40, 41].
The general insensitivity to chemotherapy in CS may be due to activation of anti-apoptotic and pro-survival pathways and therefore future treatment of advanced CS patients could benefit from targeted agents that specifically interfere with these pathways, rendering the tumours more sensitive to the conventional chemotherapeutic agents[8, 9, 40]. For instance, the anti-apoptotic proteins Bcl-2 and Bcl-XL are highly expressed in all CS subtypes and the BH-3 mimetic ABT-737 renders CS cell lines sensitive to the conventional chemotherapeutic agents doxorubicin and cisplatin[10, 40]. Survivin, a member of the inhibitor of apoptosis protein family, is expressed in CS samples and RNA interference targeted on survivin results in cell cycle arrest and increased apoptotic rates in CS cell lines. However, despite promising results in vitro, some novel approaches never make it to a clinical trial. An example of this is the combination treatment of the Bcl-2 inhibitor ABT-737 and doxorubicin. Drug companies were not interested to supply drug for a clinical trial so it remains unclear if this combination is beneficial to patient outcome.
Two recent retrospective studies as well as animal studies suggested that a subgroup of the patients may benefit from non-cytotoxic agents, chemotherapy, radiotherapy or a combination[6, 7, 41]. In systemic treatment, being either a doxorubicin-containing chemotherapy regimen or non-cytotoxic drugs as imatinib and sirolimus, significantly improved survival compared to no treatment in central CS patients with unresectable disease was shown. For patients with only locally advanced disease radiotherapy may be a good therapeutic option with a significant survival benefit compared to no treatment. Patients with mesenchymal or dedifferentiated CS may also benefit from systemic treatment, and further clinical studies are warranted looking at specific CS subtypes.
Recently also new treatment options were tested in clinical trials such as the hedgehog (Hh) inhibitor IPI-926. Hedgehog signaling was previously shown to be important in CS genesis[43–45]. CS xenograft models were treated with IPI-926 and showed a downregulation of the Hh pathway in the tumors and a significant growth inhibition in both newly planted as well as established CS tumours with a mean of 43%. Because of the strong preclinical results a randomized phase II trial studying the effect of IPI-926 compared to placebo in metastatic or locally advanced CS patients was conducted (NCT01310816). The study showed that IPI-926 is well tolerated but there was no difference in PFS or OS compared to placebo. However a small subset of patients had minor reductions in tumour size. Another Hh inhibitor that was tested in a phase II trial including advanced CS patients was GDC-0449, also called vismodegib (NCT01267955). This study did not meet its primary endpoint, but the results suggested activity of the drug in a subset of patients with progressive grade 1 or 2 conventional CS. Despite the fact that in both studies only a small subset showed benefit, it is important to do these trials even if the results do not seem promising for the whole patient group. By studying the tumor tissue of the small subset of responders, we may learn to better understand the mode of action. Moreover, this will enable the identification of biomarkers to predict which patients do respond to the treatment to improve patient selection in future trials.
According to the clinicaltrials.gov website currently 6 clinical phase I or II trials are enrolling CS patients, in all of these trials non-cytotoxic agents are being tested either alone or in combination. These treatments are based on preclinical work that has been conducted over the last years and which shows promising results. An example of this is the mTOR pathway. Dysregulation of mTOR signaling can be found in many tumor types, however in clinical trials inhibitors of mTOR so far show only modest results, which may be due to activation of the PI3K/Akt pathway. In CS, both mTOR and AKT were shown to be activated[28, 42]. Dual inhibition using BEZ235 dramatically decreased growth of CS cell lines and xenografts. The euroSARC consortium, http://www.eurosarc.eu, is starting a phase II study in unresectable conventional, dedifferentiated and mesenchymal CS with the combination of sirolimus and cyclofosfamide. An exploratory analysis of the mTOR pathway is foreseen in this study with pharmacokinetic assays on tumour biopsies taken before and after treatment (http://www.eurosarc.eu).
We conducted a search for all clinical phase I or II trials and retrospective studies that included CS patients. Because we intended to include modern imaging and study designs the survey was limited to the period from 2000 until 2013. The list of the phase I trials that met our search criteria is probably not completely reflecting the actual number of CS patients enrolled in phase I clinical trials, which is caused by the search strategy by which trials that included CS patients without mentioning them in the abstracts are very difficult to find. Some of the phase I trials could be found by using the Cochrane Controlled Trial Register or the clinicaltrials.gov database, although not all trials are registered in these databases. In the phase I trials, with an average of 34 recruited patients, only a small number of CS patients were enrolled at various dose levels which make it difficult to conclude on the effect of these new treatment options specifically for CS patients. For the phase II trials sarcoma patients were enrolled in different strata. Some strata included CS patients while the studies by Grignani and Italiano were restricted to CS patients only[46, 47].
For the retrospective studies it was difficult to make definite conclusions on the effect of systemic therapy because many different chemotherapy treatment regimens were used in patients with different stages of disease and different CS subtypes. As the biological behavior of the subtypes differs much with therefore expected different outcomes it is hard to conclude from studies where the specific subtype is not reported. The study by Cesari is very interesting because it shows that mesenchymal CS patients who had a complete surgical remission may benefit from adjuvant chemotherapy with a 10 year disease free survival that improves from 10% without chemotherapy to 76% with chemotherapy. This is in line with previous studies and the current opinion is that mesenchymal CS is a chemotherapy sensitive tumor and that patients therefore benefit from chemotherapy treatment[25, 29]. For the other CS subtypes it has generally been thought that they are insensitive to conventional chemotherapy, although for dedifferentiated CS activity was shown in individual cases and it is still undefined if chemotherapy treatment is effective[3, 12, 49]. A retrospective study with 337 dedifferentiated CS patients shows that the prognosis remains dismal, however an improvement of survival, not significant, in patients receiving chemotherapy who are under 60 years of age and had limb salvage treatment was found. Also for conventional CS more evidence is currently found that systemic treatment does improve survival.
In conclusion, CS is a difficult patient population to study in clinical trials. It is a very rare disease and most patients can be cured by surgery alone, which makes the group of patients that might need adjuvant or palliative treatment even smaller. This is also one of the reasons why it is very difficult to receive funding for these studies. However, from the current poor prognosis of non-resectable locally advanced or metastatic CS patients it is very clear that there is an unmet medical need and new treatment options are warranted. To improve the number of new treatment options for these patients it is essential to collaborate and share data on research so that future clinical trials have a sound biological rationale and can be conducted with as few patients as possible in a short timeframe.
The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 278742 (Eurosarc).
- Damron TA, Ward WG, Stewart A: Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res. 2007, 459: 40-47.View ArticlePubMedGoogle Scholar
- Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovee JV: The clinical approach towards chondrosarcoma. Oncologist. 2008, 13: 320-329.View ArticlePubMedGoogle Scholar
- Angelini A, Guerra G, Mavrogenis AF, Pala E, Picci P, Ruggieri P: Clinical outcome of central conventional chondrosarcoma. J Surg Oncol. 2012, 106: 929-937.View ArticlePubMedGoogle Scholar
- Evans HL, Ayala AG, Romsdahl MM: Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer. 1977, 40: 818-831.View ArticlePubMedGoogle Scholar
- Italiano A, Mir O, Cioffi A, Palmerini E, Piperno-Neumann S, Perrin C, Chaigneau L, Penel N, Duffaud F, Kurtz JE, Collard O, Bertucci F, Bompas E, Le Cesne A, Maki RG, Ray Coquard I, Blay JY: Advanced chondrosarcomas: role of chemotherapy and survival. Ann Oncol. 2013, 24: 2916-2922.PubMed CentralView ArticlePubMedGoogle Scholar
- Perez J, Decouvelaere AV, Pointecouteau T, Pissaloux D, Michot JP, Besse A, Blay JY, Dutor A: Inhibition of chondrosarcoma growth by mTOR inhibitor in an in vivo syngeneic rat model. PLoS One. 2012, 7: e32458-PubMed CentralView ArticlePubMedGoogle Scholar
- Bovee JV, Hogendoorn PC, Wunder JS, Alman BA: Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer. 2010, 10: 481-488.View ArticlePubMedGoogle Scholar
- van Oosterwijk JG, Anninga JK, Gelderblom H, Cleton-Jansen AM, Bovee JV: Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma. Hematol Oncol Clin North Am. 2013, 27: 1021-1048.View ArticlePubMedGoogle Scholar
- van Oosterwijk JG, Meijer D, van Ruler MA, van den Akker BE, Oosting J, Krenacs T, Picci P, Flanagan AM, Liegl-Atzwanger B, Leithner A, Athanasou N, Daugaard S, Hogendoorn PC, Bovee JV: Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFbeta as potential targets. Am J Pathol. 2013, 182: 1347-1356.View ArticlePubMedGoogle Scholar
- Hamada C: The role of meta-analysis in cancer clinical trials. Int J Clin Oncol. 2009, 14: 90-94.View ArticlePubMedGoogle Scholar
- van Oosterwijk JG, Herpers B, Meijer D, Briaire-de Bruijn IH, Cleton-Jansen AM, Gelderblom H, van de Water B, Bovee JV: Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance. Ann Oncol. 2012, 23: 1617-1626.View ArticlePubMedGoogle Scholar
- Serrone L, Zeuli M, Papaldo P, Nardoni C, Pacetti U, Cognetti F: Ifosfamide and epirubicin combination in untreated sarcomas: two treatment schedules. Onkologie. 2001, 24: 465-468.View ArticlePubMedGoogle Scholar
- Schwartz GK, Weitzman A, O'Reilly E, Brail L, de Alwis DP, Cleverly A, Barile-Thiem B, Vinciguerra V, Budman DR: Phase I and pharmacokinetic study of LY293111, an orally bioavailable LTB4 receptor antagonist, in patients with advanced solid tumors. J Clin Oncol. 2005, 23: 5365-5373.View ArticlePubMedGoogle Scholar
- Levine AM, Tulpule A, Quinn DI, Gorospe G, Smith DL, Hornor L, Boswell WD, Espina BM, Groshen SG, Masood R, Gill PS: Phase I study of antisense oligonucleotide against vascular endothelial growth factor: decrease in plasma vascular endothelial growth factor with potential clinical efficacy. J Clin Oncol. 2006, 24: 1712-1719.View ArticlePubMedGoogle Scholar
- Lockhart AC, Bukowski R, Rothenberg ML, Wang KK, Cooper W, Grover J, Appleman L, Mayer PR, Shapiro M, Zhu AX: Phase I trial of oral MAC-321 in subjects with advanced malignant solid tumors. Cancer Chemother Pharmacol. 2007, 60: 203-209.View ArticlePubMedGoogle Scholar
- Chawla SP, Chua VS, Fernandez L, Quon D, Saralou A, Blackwelder WC, Hall FL, Gordon EM: Phase I/II and phase II studies of targeted gene delivery in vivo: intravenous Rexin-G for chemotherapy-resistant sarcoma and osteosarcoma. Mol Ther. 2009, 17: 1651-1657.PubMed CentralView ArticlePubMedGoogle Scholar
- Camidge DR, Herbst RS, Gordon MS, Eckhardt SG, Kurzrock R, Durbin B, Ing J, Tohnya TM, Sager J, Ashkenazi A, Bray G, Mendelson D: A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies. Clin Cancer Res. 2010, 16: 1256-1263.View ArticlePubMedGoogle Scholar
- Herbst RS, Eckhardt SG, Kurzrock R, Ebbinghaus S, O'Dwyer PJ, Gordon MS, Novotny W, Goldwasser MA, Tohnya TM, Lum BL, Ashkenazi A, Jubb AM, Mendelson DS: Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol. 2010, 28: 2839-2846.View ArticlePubMedGoogle Scholar
- Olmos D, Postel-Vinay S, Molife LR, Okuno SH, Schuetze SM, Paccagnella ML, Batzel GN, Yin D, Pritchard-Jones K, Judson I, Worden FP, Gualberto A, Scurr M, de Bono JS, Haluska P: Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751, 871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol. 2010, 11: 129-135.PubMed CentralView ArticlePubMedGoogle Scholar
- Quek R, Wang Q, Morgan JA, Shapiro GI, Butrynski JE, Ramaiya N, Huftalen T, Jederlinic N, Manola J, Wagner AJ, Demetri GD, George S: Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res. 2011, 17: 871-879.View ArticlePubMedGoogle Scholar
- Stroppa E, Bertuzzi A, Di CG, Mussi C, Lutman RF, Barbato A, Santoro A: Phase I study of non-pegylated liposomal doxorubicin in combination with ifosfamide in adult patients with metastatic soft tissue sarcomas. Invest New Drugs. 2010, 28: 834-838.View ArticlePubMedGoogle Scholar
- Pacey S, Wilson RH, Walton M, Eatock MM, Hardcastle A, Zetterlund A, Arkenau HT, Moreno-Farre J, Banerji U, Roels B, Peachey H, Aherne W, de Bono JS, Raynaud F, Workman P, Judson I: A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors. Clin Cancer Res. 2011, 17: 1561-1570.PubMed CentralView ArticlePubMedGoogle Scholar
- Merimsky O, Meller I, Flusser G, Kollender Y, Issakov J, Weil-Ben-Arush M, Fenig E, Neuman G, Sapir D, Ariad S, Inbar M: Gemcitabine in soft tissue or bone sarcoma resistant to standard chemotherapy: a phase II study. Cancer Chemother Pharmacol. 2000, 45: 177-181.View ArticlePubMedGoogle Scholar
- Skubitz KM: Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma. Cancer Invest. 2003, 21: 167-176.View ArticlePubMedGoogle Scholar
- Nooij MA, Whelan J, Bramwell VH, Taminiau AT, Cannon S, Hogendoorn PC, Pringle J, Uscinska BM, Weeden S, Kirkpatrick A, Glabbeke M, Craft AW: Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. Eur J Cancer. 2005, 41: 225-230.View ArticlePubMedGoogle Scholar
- Maki RG, D'Adamo DR, Keohan ML, Saulle M, Schuetze SM, Undevia SD, Livingston MB, Cooney MM, Hensley ML, Mita MM, Takimoto CH, Kraft AS, Elias AD, Brockstein B, Blachère NE, Edgar MA, Schwartz LH, Qin LX, Antonescu CR, Schwartz GK: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol. 2009, 27: 3133-3140.PubMed CentralView ArticlePubMedGoogle Scholar
- Pacey S, Ratain MJ, Flaherty KT, Kaye SB, Cupit L, Rowinsky EK, Xia C, O'Dwyer PJ, Judson IR: Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a Phase II randomized discontinuation trial. Invest New Drugs. 2011, 29: 481-488.View ArticlePubMedGoogle Scholar
- Grignani G, Palmerini E, Stacchiotti S, Boglione A, Ferraresi V, Frustaci S, Comandone A, Casali PG, Ferrari S, Aglietta M: A phase 2 trial of imatinib mesylate in patients with recurrent nonresectable chondrosarcomas expressing platelet-derived growth factor receptor-alpha or -beta: An Italian Sarcoma Group study. Cancer. 2011, 117: 826-831.View ArticlePubMedGoogle Scholar
- Fox E, Patel S, Wathen JK, Schuetze S, Chawla S, Harmon D, Reinke D, Chugh R, Benjamin RS, Helman LJ: Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003. Oncologist. 2012, 17: 321-PubMed CentralView ArticlePubMedGoogle Scholar
- Italiano A, Le CA, Bellera C, Piperno-Neumann S, Duffaud F, Penel N, Cassier P, Domont J, Takebe N, Kind M, Coindre JM, Blay JY, Bui B: GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study. Ann Oncol. 2013, 24: 2922-2926.PubMed CentralView ArticlePubMedGoogle Scholar
- Schuetze SM, Zhao L, Chugh R, Thomas DG, Lucas DR, Metko G, Zalupski MM, Baker LH: Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma. Eur J Cancer. 2012, 48: 1347-1353.View ArticlePubMedGoogle Scholar
- Ha HT, Griffith KA, Zalupski MM, Schuetze SM, Thomas DG, Lucas DR, Baker LH, Chugh R: Phase II trial of cetuximab in patients with metastatic or locally advanced soft tissue or bone sarcoma. Am J Clin Oncol. 2013, 36: 77-82.View ArticlePubMedGoogle Scholar
- Schwartz GK, Tap WD, Qin LX, Livingston MB, Undevia SD, Chmielowski B, Agulnik M, Schuetze SM, Reed DR, Okuno SH, Ludwig JA, Keedy V, Rietschel P, Kraft AS, Adkins D, Van Tine BA, Brockstein B, Yim V, Bitas C, Abdullah A, Antonescu CR, Condy M, Dickson MA, Vasudeva SD, Ho AL, Doyle LA, Chen HX, Maki RG: Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol. 2013, 14: 371-382.PubMed CentralView ArticlePubMedGoogle Scholar
- Mitchell AD, Ayoub K, Mangham DC, Grimer RJ, Carter SR, Tillman RM: Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br. 2000, 82: 55-61.View ArticlePubMedGoogle Scholar
- Dickey ID, Rose PS, Fuchs B, Wold LE, Okuno SH, Sim FH, Scully SP: Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 2004, 86-A: 2412-2418.PubMedGoogle Scholar
- Staals EL, Bacchini P, Bertoni F: Dedifferentiated central chondrosarcoma. Cancer. 2006, 106: 2682-2691.View ArticlePubMedGoogle Scholar
- Grimer RJ, Gosheger G, Taminiau A, Biau D, Matejovsky Z, Kollender Y, San-Julian M, Gherlinzoni F, Ferrari C: Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer. 2007, 43: 2060-2065.View ArticlePubMedGoogle Scholar
- Dantonello TM, Int-Veen C, Leuschner I, Schuck A, Furtwaengler R, Claviez A, Schneider DT, Klingebiel T, Bielack SS, Koscielniak E: Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer. 2008, 112: 2424-2431.View ArticlePubMedGoogle Scholar
- Bernstein-Molho R, Kollender Y, Issakov J, Bickels J, Dadia S, Flusser G, Meller I, Sagi-Eisenberg R, Merimsky O: Clinical activity of mTOR inhibition in combination with cyclophosphamide in the treatment of recurrent unresectable chondrosarcomas. Cancer Chemother Pharmacol. 2012, 70: 855-860.View ArticlePubMedGoogle Scholar
- van Maldegem AM, Gelderblom H, Palmerini E, Dijkstra SD, Gambarotti M, Ruggieri P, Nout RA, van de Sande MA, Ferarri C, Ferrari S, Bovee JV, Picci P: Outcome of advanced, unresectable conventional central chondrosarcoma. Cancer. 2014, doi:10.1002/cncr.28845. [Epub ahead of print],Google Scholar
- Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS: Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am J Pathol. 2006, 168: 321-330.PubMed CentralView ArticlePubMedGoogle Scholar
- Zhang YX, van Oosterwijk JG, Sicinska E, Moss S, Remillard SP, van Wezel T, Buhnemann C, Hassan AB, Demitri GD, Bovee JV, Wagner AJ: Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy. Clin Cancer Res. 2013, 19: 3796-3807.View ArticlePubMedGoogle Scholar
- Bovee JV, van den Broek LJ, Cleton-Jansen AM, Hogendoorn PC: Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. Lab Invest. 2000, 80: 1925-1934.View ArticlePubMedGoogle Scholar
- Ng JM, Curran T: The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer. 2011, 11: 493-501.PubMed CentralView ArticlePubMedGoogle Scholar
- Campbell VT, Nadesan P, Ali SA, Wang CY, Whetstone H, Poon R, Wei Q, Keilty J, Proctor J, Wang LW, Apte SS, McGovern K, Alman BA, Wunder JS: Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth. Mol Cancer Ther. 2014, 13: 1259-View ArticlePubMedGoogle Scholar
- Schrage YM, Briaire-de Bruijn IH, de Miranda NF, van Oosterwijk J, Taminiau AH, van Wezel T, Hogendoorn PC, Bovee JV: Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. Cancer Res. 2009, 69: 6216-6222.View ArticlePubMedGoogle Scholar
- Cesari M, Bertoni F, Bacchini P, Mercuri M, Palmerini E, Ferrari S: Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. Tumori. 2007, 93: 423-427.PubMedGoogle Scholar
- Huvos AG, Rosen G, Dabska M, Marcove RC: Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. Cancer. 1983, 51: 1230-1237.View ArticlePubMedGoogle Scholar
- Yokota K, Sakamoto A, Matsumoto Y, Matsuda S, Harimaya K, Oda Y, Iwamoto Y: Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute. J Orthop Surg Res. 2012, 7: 38-PubMed CentralView ArticlePubMedGoogle Scholar
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