Sarcoma type | Category | 1st line | 2nd line | 3rd line and other |
---|---|---|---|---|
Other high grade bone sarcomas including malignant fibrous histiocytoma, leiomyosarcoma, angiosarcoma, spindle cell sarcoma, dedifferentiated chondrosarcoma |  | Doxorubicin, cisplatin ± methotrexate [101] | Ifosfamide, etoposide  ± methotrexate [102] | Gemcitabine and docetaxel [103] |
Giant cell tumour | Locally advanced unresectable/metastatic | Denosumab [175] | Â | Â |
Chordoma | Locally advanced, unresectable or metastatic: non-dedifferentiated dedifferentiated | Imatinib [171] doxorubicin or doxorubicin and cisplatin [176] | Addition of sirolimus [170] or Sunitinib [177] | Â |