Predictors of survival in patients with sarcoma admitted to the intensive care unit

Table 5 Multivariable cox proportional hazards model for overall survival

Variable	Hazard ratio	95 % CI P		p
Histological diagnosis				0.006
Unclassified high-grade sarcoma	1.000
Bones^a	0.881	0.516	1.506	0.64
Vascular^b	1.657	0.862	3.185	0.13
GIST	0.281	0.119	0.662	0.004
MFH	0.674	0.236	1.929	0.46
Muscle	2.048	0.917	4.573	0.08
Leiomyosarcoma	0.375	0.160	0.880	0.02
Liposarcoma	1.412	0.575	3.468	0.45
Synovial sarcoma	0.793	0.293	2.143	0.65
Others	0.746	0.373	1.493	0.41
Status of malignancy				0.003
Complete remission	1.000
First course of chemotherapy	2.323	0.473	11.425	0.30
Mixed response	2.720	0.444	16.677	0.28
Progression	5.172	1.075	24.874	0.04
Stable disease	2.262	0.501	10.218	0.29
Reason for ICU admission pancytopenia
No
Yes	0.351	0.226	0.546	<0.0001
Reason for ICU admission respiratory failure
No
Yes	1.703	1.125	2.579	01
CCI (continuous)	1.139	1.023	1.268	02
SOFA score at discharge (continuous)	1.210	1.141	1.283	<0.0001

Initially included in the model and then reduced by stepwise selection method: histology diagnosis, status of malignancy, number of organ metastasis, number of organ failures, and reason for ICU admission: acidosis, acute renal failure, pancytopenia, respiratory failure, and septic shock. There were 13 patients without known malignancy status who were not included in this analysis
CI confidence interval, GIST Gastrointestinal stromal tumor, MFH Malignant fibrous histiocytoma, CCI Charlson comorbidities index, SOFA Sequential Organ Failure Assessment
^aEwing sarcoma, osteosarcoma, chondrosarcoma
^bAngiosarcoma, epithelioid hemangioendothelioma

ISSN: 2045-3329