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Fig. 3 | Clinical Sarcoma Research

Fig. 3

From: Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

Fig. 3

Methylome and copy number profiling. The heatmap depicts unsupervised hierarchical clustering of methylation levels of the top 20,000 most variant probes (highest standard deviation). Each row represents a probe and each column a sample. The level of DNA methylation (beta value) is represented with a colour scale as depicted. Fourteen giant cell tumors of bone carrying H3F3A G34 mutations served as control group. For each sample (n  =  48), histological diagnosis, mutational status of H3F3A and selected chromosomal copy number alterations are indicated

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Clinical Sarcoma Research

ISSN: 2045-3329