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Fig. 4 | Clinical Sarcoma Research

Fig. 4

From: Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

Fig. 4

Distinct DNA methylation patterns in osteosarcoma subgroups and giant cell tumors of bone. a Upper part the empirical cumulative distribution function for DNA methylation levels (beta-values) is plotted individually for each subgroup. Lower part DNA methylation levels (mean beta values) regarding different genomic regions of individual osteosarcoma methylation subgroups. b Further DNA methylation analyses identified the HIST1H2BB and KLNN/PTEN promoter as the most differentially methylated region when comparing the H3F3A G34 mutant osteosarcoma subgroup (OS G34) with the H3.3 wild-type osteosarcoma group (OS H3.3 wt). Significant difference to the H3F3A G34 mutant osteosarcoma subgroup (OS G34) is indicated

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Clinical Sarcoma Research

ISSN: 2045-3329