Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

Table 1 Clinical characteristics of the six H3.3 mutant osteosarcomas

#	H3.3 status	Age at Dx (years)	Gender	Tumor location	Histology	Therapy protocol	Follow-up (months)	Status	Comments
77896	H3F3A G34W	59	Male	Distal radius	Osteoblastic	According to EUROBOSS	52	Progressive disease	Local recurrence, lung, pleura and liver metastases 49 months after Dx
79428	H3F3A G34W	75	Male	Proximal tibia	Osteoblastic/fibroblastic	Unknown	–	Unknown	No further clinical documentation available
84676	H3F3A G34W	71	Male	Distal femur	Osteoblastic/fibroblastic	According to EUROBOSS	–	Unknown	No further clinical documentation available
84712	H3F3A G34W	34	Female	Proximal fibula	Osteoblastic	According to euramos	17	Complete remission	Initially dx of an aneurysmal bone cyst treated by excochleation with bone grafting, continuous progress, re-biopsy 1 year later with dx osteosarcoma
94316	H3F3A G34R	75	Male	Distal femur	Osteoblastic/fibroblastic	No further treatment	28	Death of disease	Local recurrence and lung metastases 19 months after Dx
94314	H3F3A K27M	34	Female	Proximal femur	Osteoblastic/fibroblastic	According to EURAMOS	27	Death of disease	Traumatic fracture of the proximal femur treated with nail osteosynthesis 7 years before Dx, bone and lung metastases, bone infection

ISSN: 2045-3329