Diagnosis | Depth | Reads (M) | % on-target reads | Somatic mutations | Synonymous | Non-synonymous | INDEL | Frame-shift | Stop gain/loss |
---|---|---|---|---|---|---|---|---|---|
Osteosarcoma | |||||||||
 Germline | 88.1 | 75 | 89.1 |  |  |  |  |  |  |
 Tumour | 153.2 | 134 | 81.5 | 479 | 144 | 290 | 12 | 24 | 9 |
 PDX | 282.7 | 141 | 53.9 | 96,393 | 79,080 | 15,354 | 440 | 1334 | 139 |
Dedifferentiated liposarcoma | |||||||||
 Germline | 74.7 | 71 | 89.8 |  |  |  |  |  |  |
 Tumour | 148.5 | 123 | 79.4 | 458 | 154 | 250 | 14 | 28 | 12 |
Leiomyosarcoma | |||||||||
 Germline | 94.9 | 778 | 79.0 |  |  |  |  |  |  |
 Tumour | 145.7 | 116 | 81.1 | 384 | 118 | 218 | 15 | 26 | 7 |
Osteosarcoma | |||||||||
 Germline | 72.1 | 613 | 74.7 |  |  |  |  |  |  |
 Tumour | 175.2 | 148 | 79.0 | 575 | 179 | 331 | 18 | 30 | 17 |
 PDX | 142.1 | 123 | 80.2 | 288,522 | 232,825 | 48,320 | 1496 | 5307 | 477 |
Synovial sarcoma | |||||||||
 Germline | 71.5 | 784 | 58.3 |  |  |  |  |  |  |
 Tumour | 159.6 | 134 | 79.5 | 471 | 169 | 245 | 13 | 32 | 12 |
Ewing’s sarcoma | |||||||||
 Germline | 65.8 | 730 | 58.4 |  |  |  |  |  |  |
 Tumour | 122.7 | 128 | 61.0 | 529 | 191 | 262 | 21 | 45 | 10 |
 PDX | 141.7 | 125 | 75.5 | 7089 | 3399 | 3416 | 115 | 105 | 53 |
Undifferentiated pleomorphic sarcoma | |||||||||
 Germline | 77.1 | 677 | 75.4 |  |  |  |  |  |  |
 Tumour | 139.6 | 132 | 72.5 | 522 | 202 | 271 | 15 | 26 | 7 |
 PDX | 168 | 137 | 79.4 | 118,641 | 97,602 | 18,574 | 568 | 1651 | 207 |
Alveolar rhabdo-myosarcoma | |||||||||
 Germline | 83.1 | 727 | 86.6 |  |  |  |  |  |  |
 Tumour | 152.6 | 132 | 86.3 | 591 | 187 | 325 | 25 | 39 | 12 |
 PDX | 187.3 | 159 | 76.7 | 24,851 | 12,266 | 10,617 | 121 | 331 | 117 |
Leiomyosarcoma | |||||||||
 Germline | 98.8 | 880 | 76.7 |  |  |  |  |  |  |
 Tumour | 166 | 147 | 80.2 | 368 | 112 | 220 | 5 | 20 | 11 |
 PDX | 159.8 | 134 | 77.9 | 34,442 | 28,019 | 5701 | 183 | 470 | 67 |
Chordoma | |||||||||
 Germline | 70.7 | 617 | 77.5 |  |  |  |  |  |  |
 Tumour | 145.8 | 141 | 78.9 | 440 | 147 | 247 | 7 | 31 | 8 |
Metastatic angiosarcoma | |||||||||
 Germline | 72 | 632 | 76.1 |  |  |  |  |  |  |
 Tumour | 202.2 | 176 | 78.2 | 489 | 177 | 249 | 17 | 36 | 10 |
 PDX | 147 | 121 | 77.7 | 10,376 | 7892 | 2238 | 42 | 148 | 52 |
Undifferentiated pleomorphic sarcoma | |||||||||
 Germline | 78.6 | 692 | 82.4 |  |  |  |  |  |  |
 Tumour | 146 | 119 | 82.6 | 405 | 147 | 210 | 16 | 25 | 7 |