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Table 4 Predicted actionable therapeutics for patient 1

From: The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma

Drug

Targets hit

Potential targets

P value (hypergeometric test)

Letrozole

1

5

< 0.001

Fludarabine

1

6

0.001

Sunitinib

1

9

0.001

Gemcitabine

1

11

0.002

Imatinib

1

10

0.002

Clofarabine

1

12

0.002

Regorafenib

1

18

0.005

Cytarabine

1

18

0.005

Doxorubicin

1

104

0.133

Cisplatin

–

–

–

Methotrexate

–

–

–

Ifosfamide

–

–

–

  1. Diagnosis was of osteosarcoma. Therapeutics that the patient had received are highlighted in italics