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Table 1 Karyotypes of cytogenetically abnormal tumors previously diagnosed as MFH of bone.

From: Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features

Case No.1

Age/Sex

Diagnosis2

Site

Karyotype3

FISH4

Case 63 + 64

61/M

Myoepithelioma-like sarcoma

Humerus

42, XY, der(1)t(1;10)(p11;q11),

+dic(1;15)(p13;q26), add(6)(p11),-7,

add(7)(p22), t(8;9)(q22;p24),-10,

add(10)(q11), add(12)(q24),-15,

+add(16)(p13),-17, add(19)(p13),-20,

-20, r(21)(p13q22), r(22)(p13q13),

+1-2mar

EWSR1-,

FUS-

Case 69

49/M

Myoepithelioma-like sarcoma

Tibia

77-94 < 4n >, X,-X, del(X)(q21),-Y, add(1)

(q25), del(2)(p14)x2,-3,-4, der(4)t(4;5)

(q?31;q?15),-5,-5,-6,-8,-8,-9,-9,-9,-9,

-10,-10, add(11)(q13)x2, add(12)

(q22)x2,-13,-15,-16, add(16)(p13),-17,

-17,-17,-17,+18,-19, add(20)(p13)x4,

-21,-21, inc

EWSR1-,

FUS-

Case 88

70/F

Myoepithelioma-like sarcoma

Femur

54-58 < 2n >, XX,+der(1;9)(q10;q10),

+i(5)(p10),+add(6)(q13),+7,+del(8)

(q21-22)x2,-9,+15,+20,+20,+20,+22,

+22,+3-4 mar

Failure

Case 89

53/M

Leiomyosarcoma

Femur

(bone infarct)

58-61, XX,-Y,+i(1)(q10),-3,-4,-5,-6,

+add(7)(q11), add(9)(p21)x2,-10,-10,

-11, i(11)(p10),-12, add(12)(p13)x2,

-13,-14, i(15)(q10),-16,-17,-17, add(19)

(q13),+20,+i(20)(p10),-21, der(21)

t(1;21)(p13;p11),-22,+2-4mar

ND

Case 985

47/M

Leiomyosarcoma

Os ileum

130-190 < 6n-8n >, X?inc

ND

Case 68

76/F

UPS with incomplete myogenic differentiation

Femur

59-113, X?, inc/46, XX, inv(9)(p11q12)c

ND

Case 66

68/F

UPS

Tibia

84-106 < 5n >, XX,-X,-X,-X,?add(1)

(q42), del(1)(p11), del(1)(q12), der(1)

add(1)(q42)del(1)(p11), der(1)add(1)

(q44)add(1)(p11)hsr(?), add(2)(q3?3),

i(3)(p10),-4, der(4)add(4)(p16)hsr(4)

(p16), i(5)(q10),+add(6)(q11)x2,-7,

der(8)t(1;8)(p22;p2?3)x1-2, i(10)(q10),

-13,-13, add(13)(p11),-14, add(14)(p11),

?i(14)(q10),-15,-15,-16,-16,-17,-17,

?add(17)(p11),-18,-18, der(18)add(18)

(p11)hsr(?),-19,-21,-21,-22,?add(22)

(q13), inc

ND

Case 105

66/F

UPS

Unknown

67-77, XX,-X,+1,-2, add(2)(p11)x2,-3,

+4,-8,-8,+9, dic(9;17)(p21;p13)x2,+10,

+12,+13, der(14)t(2;14)(q11;p11),+16,

+17,+19,-20,-22

ND

Case 100

52/F

Osteosarcoma

Os ischium

32-44, X,-X, add(1)(p11),-3,-4,-6,-9,-10,

der(12)add(12)(p12)del(12)(q22),-13,

-13,-14,-15,-16,-17,-18,-19,-21, add(21)

(p11),-22, der(22)t(3;22)(p11;q11)

ND

Case 86 + 94

51/M

SCS NOS

(metastatic carcinoma?)

Femur

44-48, XY, der(1)t(1;18)(p36;q11),

del(4)(p15), del(7)(q22), del(8)(p11),

dic(8;10)(p11;p?),-13,-15, del(16)(q22),

add(19)(p13), add(20)(q13),+add(21)

(q22),+r,+1-7mar/80-83, idemx2

ND

Case 91

29/M

Dubious biphasic sarcoma

Humerus

Lung met.

47, XY, add(19)(q13),+mar

88-90, XXYY, der(2)t(2;7)(p21;q11)x2,

-4,-4,+i(5)(p10)x2,-7,-7,-12, del(12)

(q22)x2, add(13)(q22)x2,+18,-21,-21,

+3-4 mar

ND

  1. 1Case numbers are identical to those in the publication by Romeo et al. [6].
  2. 2All tumors were classified as grade 3 tumors (3-grade scale). UPS = undifferentiated pleomorphic sarcoma; SCS NOS = spindle cell sarcoma not otherwise specified.
  3. 3All karyotypes are composite karyotypes.
  4. 4ND = not done.
  5. 5Karyotype on sample obtained after chemotherapy.