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Table 2 Demonstrates the treatment received by each patient including the local treatment and outcome to date

From: Interval compressed vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, etoposide in patients with advanced Ewing’s and other Small Round Cell Sarcomas

Patient No.

Age at diagnosis

Gender

Diagnosis

Primary site

Site of metastases

Prior chemo

No of VDC/IE cycles

Cycle treatment Interval (days)

Dose reduction

Local treatment

Outcome

1

14

F

EFT

Kidney

Bone, peritoneum

No

14

19.9

Yes

Surgery, R1 resection, poor response to chemo on histology

Relapsed 3 months after completing VDC/IE – receiving palliative chemotherapy

2

22

M

EFT

Ilium

Lung, bone, BM

No

12

17.1

Yes

RT - 50Gy in 30# 2 phases

Relapsed 10 months post treatment and died 23 months post treatment

4

29

M

EFT

Femur

Bone, BM

No

14

14.9

Yes

Surgery, R0 resection with good response to chemo on histology

Relapsed 7 months post treatment and died 11 months after treatment

5

15

F

EFT

Unknown

Lung, Bone, BM

No

11

17.5

Yes

None

Progressed at cycle 11 and died 3 months later

6

17

M

EFT

Ilium

Bone

Yes

8

15.4

No

RT 55Gy in 31#

Relapsed 4 month post treatment. Died 15 months after completing treatment.

7

29

M

EFT

ilium

Lung, Bone

No

14

16.5

Yes

RT 45Gy in 25#

Progressed at the end of treatment and died 3 months later

11

21

M

EFT

Sacrum

bone

No

11

17.4

No

RT 50.4Gy in 28# in 2 phases to sacrum and 55Gy in 30# to chest

Relapsed 4 months post treatment and died 6 months post treatment

12

19

M

EFT

Pelvis

Bone

No

14

16.5

No

RT 55Gy in 30#

Disease free at 4 months post treatment

15

19

M

EFT

Metatarsal

Lung, Bone

No

12

17.9

No

Surgery, close margins, poor response to chemo on histology

Relapsed in lung 11 months treatment and then lost to follow up in 8 months after relapse as living abroad.

16

17

M

EFT

First rib

Bone

Yes

12

18.5

Yes

RT 55.8Gy in 31#

Died of disease 4 months after completing treatment.

3

37

F

UHGRCS

Ilium

none

No

4

16.2

No

Surgery, R0 resection. Poor response to chemo on histology

Disease free 25 months post treatment

14

27

F

UHGRCS

mediastinum

None

No

11

19.9

Yes

Surgery, R0 resection with excellent response to chemo on histology

Disease free 1 month post treatment

8

24

M

DSRCT

n/a

Peritoneal cavity, lungs

No

14

15.9

No

None

Progressed 5 months post treatment, while on maintenance VAC chemotherapy and is having further palliative chemo

9

31

M

DSCRT

n/a

Peritoneal cavity Lung, bone

No

14

15

No

None

Progressed 4 months post treatment and is currently having further palliative chemo

10

19

M

DSCRT

n/a

Peritoneal cavity, liver

No

14

14.9

No

None

No progression 6 months post treatment on maintenance VAC

13

22

M

DSCRT

n/a

Peritoneal cavity

No

14

14.9

No

None

No evidence of progression one month post treatment

  1. M, Male; F,Female; EFT, Ewing’s family of tumors; UHGRCS,Undifferentiated high grade round cell sarcoma; DSRCT, Desmoplastic small round cell tumour; RT, radiotherapy; R1, microscopically positive margins; R0, complete excision.