Clinical Sarcoma Research

Table 1 Characteristics of the nine case–control studies of subsequent sarcoma after radiotherapy treatment for cancer with individual dose estimates

From: Sarcoma risk after radiation exposure

					Average age at diagnosis		Dose (controls)		ERR/Gy
Reference	2nd cancer	1st cancer	Cases	Controls	1st cancer	Sarcoma	Average	Max	(& 95% Cl)
Radiotherapy in Childhood
Tucker 1987 [4]	Bone Sarcoma	Childhood	68	209	7 yrs	na	27 Gy	60+ Gy	0.06 (0.01–0.20)*
Hawkins 1996 [5]	Bone Sarcoma	Childhood	50	168	ns	na	5 Gy	50+ Gy	0.16 (0.07–0.37)*
Le Vu 1998 [6]	Osteosarcoma	Childhood	32	160	6 yrs	15 yrs	8 Gy	83 Gy	1.4 (0.1–21.8)
Wong 1997 [7]	Soft tissue sarcoma	Retinoblastoma	31	89	<2 yrs	15 yrs	11 Gy	112 Gy	0.17 (0.025–16.3)
Menu-Branthomme 2004 [8]	Soft tissue sarcoma	Childhood	23	111	8 yrs	21 yrs	12 Gy	50 Gy	na
Jenkinson 2007 [9]	Soft tissue sarcoma	Childhood	53	179	7 yrs	17 yrs	5 Gy	30+ Gy	na
Radiotherapy in Adulthood
Boice 1988 [10]	Bone Sarcoma	Cervix	15	155	50 yrs	67 yrs	22 Gy	10+ Gy	0.02 (−0.03–0.21)*
Boice 1988 [10]	Soft tissue sarcoma	Cervix	46	598	50 yrs	67 yrs	7 Gy	10+ Gy	−0.05 (−0.11–0.13)*
Rubino 2005 [11]	All sarcomas	Breast	14	98	55 yrs	62 yrs	19 Gy	80 Gy	0.05 (<0-1.18)

na – not available. ERR/Gy – excess relative risk per Gray. * UNSCEAR [12].

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