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Table 2 Standardized Incidence Ratios (SIRs) for subsequent primary sarcoma after any 1st cancer in adulthood according to radiotherapy and time since first cancer diagnosis, SEER 9 1973-2008

From: Sarcoma risk after radiation exposure

 

Bone sarcoma

Soft tissue sarcoma

Time since 1st

Radiotherapy

No radiotherapy

Radiotherapy

No radiotherapy

Cancer diagnosis

Obs

SIR

Obs

SIR

Obs

SIR

Obs

SIR

1-4 yrs

34

1.49*

77

1.32*

135

1.22*

311

1.15*

5-9 yrs

43

2.74*

56

1.24

185

2.22*

271

1.21*

10-14 yrs

23

3.23*

34

1.31

78

2.04*

141

1.06

15+ yrs

23

4.35*

24

0.94

62

2.20*

159

1.21*

Total

123

2.42*

191

1.23*

460

1.77*

882

1.16*

  1. *p < 0.05. Obs-observed number of subsequent primary sarcomas. Analysis includes adulthood (age 20–79 years at diagnosis) 1+ year survivors of any 1st cancer (excluding bone sarcoma or soft tissue sarcoma, respectively). Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.
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Clinical Sarcoma Research

ISSN: 2045-3329