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Table 3 Standardized Incidence Ratios for subsequent primary sarcoma after any 1st cancer in adulthood according to radiotherapy and age at 1st cancer diagnosis, SEER 9 1973-2008

From: Sarcoma risk after radiation exposure

 

Bone sarcoma

Soft tissue sarcoma

Age at 1st

Radiotherapy

No radiotherapy

Radiotherapy

No radiotherapy

Cancer diagnosis

Obs

SIR

Obs

SIR

Obs

SIR

Obs

SIR

20-39 yrs

13

4.40*

10

1.31

52

5.32*

58

2.25*

40-59 yrs

42

3.71*

40

1.23

129

2.41*

219

1.37*

60-79 yrs

40

2.60*

57

1.31

177

1.83*

302

1.15*

  1. *p < 0.05. Obs-observed number of subsequent primary sarcomas. SIR-standardized incidence ratio. Analysis includes adulthood (age 20–79 years at diagnosis) 1+ year survivors of any 1st cancer (excluding bone sarcoma or soft tissue sarcoma, respectively). Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.
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