From: Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma
Characteristic | Resectable tumor No. (%) | Advanced disease No. (%) | Total No. (%) | P value |
---|---|---|---|---|
Total no. of patients | 26 | 11 | 37 | Â |
Sex | Â | Â | Â | 0.48 |
   Male | 15 (57.7) | 3 (27.3) | 18 (48.6) |  |
   Female | 11 (42.3) | 8 (72.7) | 19 (51.4) |  |
Race | Â | Â | Â | 0.35 |
   White | 15 (57.7) | 10 (90.9) | 25 (67.6) |  |
   Hispanic | 6 (23.0) | 1 (9.1) | 7 (18.9) |  |
   African American | 4 (15.4) | 0 (0) | 4 (10.8) |  |
   Asian | 1 (3.8) | 0 (0) | 1 (2.7) |  |
Age in years at the time of treatment, mean ± SD (range) | 42.3 ± 12.8 (14-72) | 43.8 ± 6.4 (37-55) | 42.7 ± 11.4 (14-72) | 0.87 |
Tumor size in cm, median (range) | 14.9 (6-23.3) | Â | Â | Â |
Disease site | Â | Â | Â | Â |
   Lower extremity | 23 (88.5) |  |  |  |
   Neck | 1 (3.8) |  |  |  |
   Retroperitoneum | 1 (3.8) |  |  |  |
   Perineum | 1 (3.8) |  |  |  |
Number of disease sites | Â | Â | Â | Â |
Single site (abdominal cavity, bone a , heart, mediastinum) | Â | 5 (45.5) | Â | Â |
2 sites b | Â | 5 (45.5) | Â | Â |
3 sites c | Â | 1 (9.1) | Â | Â |
Tumor side | Â | Â | Â | Â |
   Left | 15 (57.7) |  |  |  |
   Right | 11 (42.3) |  |  |  |
Hypercellular round cell tumor | 1 (3.8) | 1 (9.1) | 2 (5.4) | 0.82 |
Chemotherapy | Â | Â | Â | Â |
   Median no. of chemotherapy cycles, median (range) | 6 (4-6) | 6 (5-8) | 6 (4-8) | 0.02 |
   Intensified doxorubicin dose (90 mg/m2) | 8 (30.7) | 3 (27.2) | 11 (33.3) | 1.00 |
Surgery (R0 intent) | 26 (100) | Â | Â | Â |
   Free margins | 21 (80.8) |  |  |  |
   Positive margins (R1) | 5 (19.2) |  |  |  |
Radiotherapy | Â | Â | Â | Â |
   Before surgery | 21 (80.8) |  |  |  |
   After surgery | 5 (19.2) |  |  |  |