Mouse models of sarcomas: critical tools in our understanding of the pathobiology

Table 2 Additional mouse models of human sarcomas

Tumor type	Gene alteration(s)	Agent used	Significance	Proposed karyotype	Reference
Synovial Sarcoma	SYT-SSX2 fusion	Myf 5-Cre	Expression of the SYT-SSX2 transgene resulted in 100% penetrant synovial sarcomas	Translocation	[60, 61]
Myxoid Liposarcoma	TLS-CHOP fusion w/ p53 deletion	Prx-Cre	Deletion of p53 cooperates in the formation of liposarcomas	Translocation	[62]
Neurofibroma MPNST	NF1 deletion w or w/o p53 and p19Arf deletions	Germline, POa-Cre, or 3.9Periostin-Cre	Deletion of p53 and p19Arf stimulate MPNST development	Complex	[63, 64]
Uterine leiomyosarcoma	Lmp2 deletion	None	Loss of Lmp2 results in uterine leiomyosarcoma formation	Complex	[65, 66]
Uterine leiomyosarcoma	TDGF1/CRIPTO overexpression	MMTV-promoter	TDGF1/CRIPTO expression results in uterine leiomyosarcoma development	Complex	[67]

ISSN: 2045-3329