Figure 1
From: Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib
Patient 1 tumor biopsy consistent with the diagnosis of extraskeletal myxoid chondrosarcoma. Histology shows nests/cords of epithelioid cells embedded into a myxoid matrix (HandE) (panel A), characterized by diffuse pancytokeratin (AE1/AE3) cytoplasmic decoration (panel B) and PPARG nuclear expression (panel C). Panel D shows the FISH rearranged pattern for CHN, consisting in a fusion green/red signal, corresponding to an intact copy of the gene, and a split signal (red and green separated, white arrows) corresponding to the rearranged allele.