Figure 2
From: The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease
Negative impact of CXCR4 expression in therapy-naïve Ewing sarcoma. Kaplan-Meier survival analysis. CXCR4 expression level plotted according to the cut-off values as shown in Table1: CXCR4 negative (absent (−) expression), CXCR4 positive (weak (+/−), moderate (+) or strong (++) expression). A. Inferior survival of patients with CXCR4 positive therapy-naïve tumors compared to patients with tumors lacking expression of this protein. B. Expression level-dependent impact of CXCR4 expression on patients’ overall survival. Inferior survival of patients with therapy-naïve tumors demonstrating strong CXCR4 expression compared to patients with weak-moderate or absent expression of this protein.