Table 1 Immunohistochemical expression analysis of the CXCR4-CXCL12 axis in Ewing sarcoma
From: The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease
UPNa | sample type (years after diagnosis) | CXCR4b | CXCL12 | |
|---|---|---|---|---|
| Â | Â | Â | tumor | stroma |
1 | lung metastasis (3) | - | - | +/− |
|  | bone metastasis (7) | - | - | +/− |
2 | lung metastasis (2) | - | + | + |
3 | therapy-naive biopsy | +/− | + | + |
|  | lung metastasis (5,5) | - | - | +/− |
4 | therapy-naive biopsy | ++ | +/− | + |
| Â | lung metastasis (3) | - | + | ++ |
| Â | lung metastasis (4) | - | + | ++ |
5 | therapy-naive biopsy | ++ | +/− | ++ |
|  | bone metastasis (1) | n.e. | +/− | + |
6 | therapy-naive biopsy | + | ++ | n.e. |
|  | lung metastasis (1) | +/− | +/− | +/− |
7 | therapy-naive biopsy | ++ | ++ | + |
8 | therapy-naive biopsy | ++ | +/− | + |
| Â | bone metastasis (2,5) | + | ++ | ++ |
9 | therapy-naive biopsy | - | + | + |
| Â | lung metastasis (0,5) | + | + | ++ |
10 | therapy-naive biopsy | + | - | +/− |
11 | therapy-naive biopsy | - | + | +/− |
12 | therapy-naive biopsy | + | +/− | + |
13 | therapy-naive biopsy | ++ | - | +/− |
14 | therapy-naive biopsy | - | +/− | + |
15 | therapy-naive biopsy | - | - | +/− |
16 | therapy-naive biopsy | - | + | +/− |
17 | therapy-naive biopsy | - | + | + |
18 | therapy-naive biopsy | + | +/− | +/− |
19 | therapy-naive biopsy | - | +/− | + |
20 | therapy-naive biopsy | +/− | - | + |
21 | therapy-naive biopsy | - | - | +/− |
22 | therapy-naive biopsy | - | - | - |
23 | therapy-naive biopsy | - | +/− | +/− |
24 | therapy-naive biopsy | +/− | +/− | +/− |
25 | therapy-naive biopsy | ++ | - | - |
26 | therapy-naive biopsy | - | + | + |
27 | therapy-naive biopsy | + | +/− | + |
28 | therapy-naive biopsy | ++ | +/− | + |
29 | therapy naive biopsy | - | - | +/− |
30 | therapy-naive biopsy | ++ | ++ | + |
31 | therapy-naive biopsy | + | - | ++ |
32 | therapy-naive biopsy | + | + | + |
33 | therapy-naive biopsy | - | - | +/− |
34 | therapy-naive biopsy | ++ | + | + |
35 | therapy-naive biopsy | + | - | +/− |
36 | therapy-naive biopsy | + | + | + |
37 | therapy-naive biopsy | + | - | + |
38 | therapy-naive biopsy | ++ | n.e. | n.e. |
39 | therapy-naive biopsy | ++ | - | +/− |
40 | therapy-naive biopsy | - | - | +/− |
41 | therapy-naive biopsy | + | + | + |
42 | therapy-naive biopsy | + | - | +/− |
43 | therapy-naive biopsy | - | ++ | + |
44 | therapy-naive biopsy | - | + | + |
45 | lung metastasis (1,5) | +/− | +/− | ++ |
|  | bone metastasis (2,5) | ++ | +/− | + |
| Â | lung metastasis (2,5) | - | + | ++ |
|  | lung metastasis (4) | - | +/− | ++ |
|  | lung metastasis (4) | +/− | +/− | + |
| Â | lung metastasis (5) | + | + | + |
46 | therapy-naive biopsy | + | + | + |
47 | therapy-naive biopsy | +/− | ++ | ++ |