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Table 1 Common Ewing sarcoma/PNET family of tumours chimeric fusion gene translocations: Most frequently implicated chimeric fusion gene translocations.

From: Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours

Genes

Translocation

EWS FLI1

t(11;22)(q24;q12)

EWS ERG

t(21;22)(q22;q12)

EWS ETV1

t(7;22)(p22;q12)

EWS E1AF

t(17;22)(q12;q12)

EWS FEV

t(2;22)(q33;q12) *

  1. *Other ETS family partners: ETV4, PATZ1 (~5%), FUS-ERG (< 1%)
  2. (Primer of the Molecular Biology of Cancer. Cancer Principles and Practice. Chapter 26; Sarcomas, p 334 Table 26.1).