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Table 1 In vitro cytotoxicity (IC50 values) of histone deacetylase inhibitors to chemo-sensitive and -resistant EWS cell linesa

From: Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis

cell line

NaB (mM)

SAHA (μM)

MS-275 (μM)

chemo-sensitive

   

SK-ES-1

1.43

2.85

3.72

TC71

7.85

2.96

30.71

chemo-resistant

   

CADO-ES

38.99

3.92

49.97

STA-ET2.1

0.61

1.58

10.06

  1. a 'natural' sensitivity of specific cell lines to chemotherapeutic drugs, as previously described [27, 35].
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Clinical Sarcoma Research

ISSN: 2045-3329