Table 1 A summary of spontaneous transformation studies with mouse BMMSCs
From: Mesenchymal stem cell transformation and sarcoma genesis
Transformation after | Type of sarcoma | Associated genetic event(s) | Reference |
|---|---|---|---|
Long term culture | Osteosarcoma | Aneuploidy + CDKN2A/p16 loss | [4] |
Abnormal karyotype | [6] | ||
Fibrosarcoma | p53 mutations | [24] | |
Chromosomal instability + TERT and c-myc expression | [16] | ||
Undiff. soft tissue sarcomas | Aneuploidy + chromosomal translocations | [17] | |
Short term culture | Soft tissue sarcomas | Aneuploidy | [18] |