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Table 1 Demographic information and tumor characteristics of patients included in genotyping ancillary study

From: Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations

  Overall sample Sex stratified Race stratified
  N = 279 Male (n = 142) Female (n = 137) White (n = 229) Other (n = 50)
Age: Median (range) 58.0 (18 – 85) 57.0 (18 – 85) 58.0 (18 – 81) 59.0 (18 – 85) 53.0 (27 – 78)
Sex: N (%)      
Male 142 (51) --- --- --- ---
Female 137 (49) --- --- --- ---
Race: N (%)      
White 229 (82) 122 (86) 107 (78) --- ---
Other 50 (18) 20 (14) 30 (22) --- ---
Tumor Size: Median (range) 6.5 (3.0 – 37.0) 6.0 (3.0 – 37.0) 6.5 (3.0 – 28.0) 6.5 (3.0 – 37.0) 6.0 (3.1 – 30.0)
Tumor Size: N(%)      
<5 cm 79 (28) 41 (29) 38 (28) 65 (28) 14 (28)
5-10 cm 146 (52) 72 (51) 74 (54) 119 (52) 27 (54)
>10 cm 54 (19) 29 (20) 25 (18) 45 (20) 9 (18)
Mitotic Rate: Median (range) 3 (0 – 351) 3 (0 – 351) 3 (0 – 207) 3 (0 – 351) 4.5 (0 – 81)
Mitotic Rate: N(%)      
<5 156 (60) 77 (58) 79 (63) 132 (62) 24 (50)
≥5 104 (40) 57 (42) 47 (37) 80 (38) 24 (50)
Missing 19 8 11 17 2
Tumor Location: N(%)      
Stomach 182 (66) 97 (69) 85 (63) 146 (64) 36 (74)
Small Intestine 85 (31) 39 (28) 46 (34) 77 (34) 8 (16)
Rectum 2 (1) 1 (1) 1 (1) 1 (0) 1 (2)
Other 8 (3) 4 (3) 4 (3) 4 (2) 4 (8)
Missing 2 1 1 1 1
Mutation Type: N(%)      
Exon 9 15 (5) 9 (6) 6 (4) 15 (7) 0 (0)
Exon 11 195 (70) 95 (67) 100 (73) 153 (67) 42 (84)
Exon 13 3 (1) 0 (0) 3 (2) 2 (1) 1 (2)
Exon 14 1 (0) 1 (1) 0 (0) 1 (0) 0 (0)
Exon 17 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
PDGFRA 29 (10) 21 (15) 8 (6) 25 (11) 4 (8)
Wild type 36 (13) 16 (11) 20 (15) 33 (14) 3 (6)
Exon 11 mutation type: N(%)      
557-558 deletion 66 (34) 33 (35) 33 (33) 51 (33) 15 (36)
Other deletion 45 (23) 25 (26) 20 (20) 34 (22) 11 (26)
Insertion 28 (14) 14 (15) 14 (14) 23 (15) 5 (12)
Point Mutation 56 (29) 23 (24) 33 (33) 45 (29) 11 (26)
PDGFRA mutation type: N(%)      
D842V 12 (41) 10 (48) 2 (25) 10 (40) 2 (50)
Other 17 (59) 11 (52) 6 (75) 15 (60) 2 (50)