From: Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours
Gene (abbreviation) | Gene name | PTSMT (mean) | Leiomyomas (mean) | Significance |
---|---|---|---|---|
ANGPT1 | Angiopoietin 1 | 0.03 | 0.51 | n.s. |
ANGPT2 | Angiopoietin 2 | 0.91 | 0.31 | p = 0.0303 |
ANGPTL1 | Angiopoietin-like 1 | 0.05 | 0.05 | n.s. |
ANGPTL4 | Angiopoietin-like 4 | 0.03 | 0.05 | n.s. |
BAI1 | Brain-specific angiogenesis inhibitor 1 | 0.06 | 0.18 | n.s. |
CAV2 | Caveolin 2 | 0.84 | 2.35 | n.s. |
CDK1 | Cyclin-dependent kinase 1 | 0.01 | 0.01 | n.s. |
CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 4.25 | 7.55 | n.s. |
EPHB4 | EPH receptor B4 | 0.06 | 2.50 | p = 0.0025 |
FGF2 | Fibroblast growth factor 2 (basic) | 0.01 | 0.16 | p = 0.0121 |
FGFR1/FLT2 | Fibroblast growth factor receptor 1 | 3.36 | 21.33 | p = 0.0051 |
GREM1 | Gremlin 1, DAN family BMP antagonist | 0.14 | 0.20 | n.s. |
HGF | Hepatocyte growth factor | 0.02 | 0.07 | p = 0.0242 |
HIF1A | Hypoxia inducible factor 1, alpha subunit | 6.48 | 13.81 | p = 0.0051 |
IL8 | Interleukin 8 | 0.60 | 0.03 | n.s. |
LECT1 | Leukocyte cell derived chemotaxin 1 | 0.11 | Not detectable | -- |
MDK | Midkine (neurite growth-promoting factor 2) | 0.14 | 1.24 | p = 0.0061 |
MMP2 | Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) | 1.19 | 34.07 | p = 0.0025 |
NOS3 | Nitric oxide synthase 3 (endothelial cell) | 0.05 | 0.31 | p = 0.0025 |
NOTCH4 | Notch 4 (receptor) | 0.28 | 2.68 | p = 0.0025 |
NOX4 | NADPH oxidase 4 | 0.05 | 1.32 | p = 0.0061 |
NRP1 | Neuropilin 1 | 0.17 | 0.82 | n.s. |
OLR1 | Oxidized low density lipoprotein (lectin-like) receptor 1 | 0.04 | 0.02 | n.s. |
PDGFA | Platelet-derived growth factor alpha polypeptide | 0.36 | 0.12 | p = 0.0480 |
PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | 1.66 | 7.31 | n.s. |
PDPN | Podoplanin | 0.09 | 3.36 | p = 0.0061 |
PECAM1/CD31 | Platelet/endothelial cell adhesion molecule | 20.10 | 6.76 | p = 0.0303 |
PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 0.41 | 0.03 | p = 0.0061 |
PTRF | Polymerase I and transcript release factor | 7.68 | 56.80 | p = 0.0025 |
S1PR1 | Sphingosine-1-phosphate receptor 1 | 0.15 | 0.76 | p = 0.0172 |
SERPINF1 | Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.19 | 6.45 | p = 0.0061 |
STAB1 | Stabilin 1 | 0.06 | 0.16 | n.s. |
TEK | TEK tyrosine kinase, endothelial | 0.11 | 1.17 | p = 0.0043 |
TGFBR1 | Transforming growth factor, beta receptor 1 | 0.05 | 0.38 | p = 0.0025 |
THBS1 | Thrombospondin 1 | 13.56 | 134.17 | p = 0.0025 |
TIMP2 | TIMP metallopeptidase inhibitor 2 | 9.32 | 54.78 | p = 0.0025 |
TNFAIP2 | Tumor necrosis factor, alpha-induced protein 2 | 0.08 | 0.01 | n.s. |
TYMP | Thymidine phosphorylase | 0.17 | 0.08 | p = 0.0480 |
VCAM1 | Vascular cell adhesion molecule 1 | 0.18 | 0.95 | p = 0.0303 |
VEGFA | Vascular endothelial growth factor A | 3.38 | 36.05 | p = 0.0025 |
VEGFC | Vascular endothelial growth factor C | 0.47 | 1.66 | p = 0.0043 |
VEGFD/FIGF | C-fos induced growth factor (vascular endothelial growth factor D) | 0.01 | 0.23 | n.s. |
VEGFR1/FLT1 | Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.15 | 0.73 | p = 0.0061 |
VEGFR2/KDR | Kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.26 | 3.48 | p = 0.0061 |
VEGFR3/FLT4 | Fms-related tyrosine kinase 4 | 0.08 | 0.10 | n.s. |