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Table 1 Expression profile of angiogenesis-related genes

From: Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours

Gene (abbreviation)

Gene name

PTSMT (mean)

Leiomyomas (mean)

Significance

ANGPT1

Angiopoietin 1

0.03

0.51

n.s.

ANGPT2

Angiopoietin 2

0.91

0.31

p = 0.0303

ANGPTL1

Angiopoietin-like 1

0.05

0.05

n.s.

ANGPTL4

Angiopoietin-like 4

0.03

0.05

n.s.

BAI1

Brain-specific angiogenesis inhibitor 1

0.06

0.18

n.s.

CAV2

Caveolin 2

0.84

2.35

n.s.

CDK1

Cyclin-dependent kinase 1

0.01

0.01

n.s.

CXCL1

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

4.25

7.55

n.s.

EPHB4

EPH receptor B4

0.06

2.50

p = 0.0025

FGF2

Fibroblast growth factor 2 (basic)

0.01

0.16

p = 0.0121

FGFR1/FLT2

Fibroblast growth factor receptor 1

3.36

21.33

p = 0.0051

GREM1

Gremlin 1, DAN family BMP antagonist

0.14

0.20

n.s.

HGF

Hepatocyte growth factor

0.02

0.07

p = 0.0242

HIF1A

Hypoxia inducible factor 1, alpha subunit

6.48

13.81

p = 0.0051

IL8

Interleukin 8

0.60

0.03

n.s.

LECT1

Leukocyte cell derived chemotaxin 1

0.11

Not detectable

--

MDK

Midkine (neurite growth-promoting factor 2)

0.14

1.24

p = 0.0061

MMP2

Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)

1.19

34.07

p = 0.0025

NOS3

Nitric oxide synthase 3 (endothelial cell)

0.05

0.31

p = 0.0025

NOTCH4

Notch 4 (receptor)

0.28

2.68

p = 0.0025

NOX4

NADPH oxidase 4

0.05

1.32

p = 0.0061

NRP1

Neuropilin 1

0.17

0.82

n.s.

OLR1

Oxidized low density lipoprotein (lectin-like) receptor 1

0.04

0.02

n.s.

PDGFA

Platelet-derived growth factor alpha polypeptide

0.36

0.12

p = 0.0480

PDGFRA

Platelet-derived growth factor receptor, alpha polypeptide

1.66

7.31

n.s.

PDPN

Podoplanin

0.09

3.36

p = 0.0061

PECAM1/CD31

Platelet/endothelial cell adhesion molecule

20.10

6.76

p = 0.0303

PTGS1

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

0.41

0.03

p = 0.0061

PTRF

Polymerase I and transcript release factor

7.68

56.80

p = 0.0025

S1PR1

Sphingosine-1-phosphate receptor 1

0.15

0.76

p = 0.0172

SERPINF1

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

0.19

6.45

p = 0.0061

STAB1

Stabilin 1

0.06

0.16

n.s.

TEK

TEK tyrosine kinase, endothelial

0.11

1.17

p = 0.0043

TGFBR1

Transforming growth factor, beta receptor 1

0.05

0.38

p = 0.0025

THBS1

Thrombospondin 1

13.56

134.17

p = 0.0025

TIMP2

TIMP metallopeptidase inhibitor 2

9.32

54.78

p = 0.0025

TNFAIP2

Tumor necrosis factor, alpha-induced protein 2

0.08

0.01

n.s.

TYMP

Thymidine phosphorylase

0.17

0.08

p = 0.0480

VCAM1

Vascular cell adhesion molecule 1

0.18

0.95

p = 0.0303

VEGFA

Vascular endothelial growth factor A

3.38

36.05

p = 0.0025

VEGFC

Vascular endothelial growth factor C

0.47

1.66

p = 0.0043

VEGFD/FIGF

C-fos induced growth factor (vascular endothelial growth factor D)

0.01

0.23

n.s.

VEGFR1/FLT1

Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

0.15

0.73

p = 0.0061

VEGFR2/KDR

Kinase insert domain receptor (a type III receptor tyrosine kinase)

0.26

3.48

p = 0.0061

VEGFR3/FLT4

Fms-related tyrosine kinase 4

0.08

0.10

n.s.