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Table 1 Expression profile of angiogenesis-related genes

From: Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours

Gene (abbreviation) Gene name PTSMT (mean) Leiomyomas (mean) Significance
ANGPT1 Angiopoietin 1 0.03 0.51 n.s.
ANGPT2 Angiopoietin 2 0.91 0.31 p = 0.0303
ANGPTL1 Angiopoietin-like 1 0.05 0.05 n.s.
ANGPTL4 Angiopoietin-like 4 0.03 0.05 n.s.
BAI1 Brain-specific angiogenesis inhibitor 1 0.06 0.18 n.s.
CAV2 Caveolin 2 0.84 2.35 n.s.
CDK1 Cyclin-dependent kinase 1 0.01 0.01 n.s.
CXCL1 Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 4.25 7.55 n.s.
EPHB4 EPH receptor B4 0.06 2.50 p = 0.0025
FGF2 Fibroblast growth factor 2 (basic) 0.01 0.16 p = 0.0121
FGFR1/FLT2 Fibroblast growth factor receptor 1 3.36 21.33 p = 0.0051
GREM1 Gremlin 1, DAN family BMP antagonist 0.14 0.20 n.s.
HGF Hepatocyte growth factor 0.02 0.07 p = 0.0242
HIF1A Hypoxia inducible factor 1, alpha subunit 6.48 13.81 p = 0.0051
IL8 Interleukin 8 0.60 0.03 n.s.
LECT1 Leukocyte cell derived chemotaxin 1 0.11 Not detectable --
MDK Midkine (neurite growth-promoting factor 2) 0.14 1.24 p = 0.0061
MMP2 Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) 1.19 34.07 p = 0.0025
NOS3 Nitric oxide synthase 3 (endothelial cell) 0.05 0.31 p = 0.0025
NOTCH4 Notch 4 (receptor) 0.28 2.68 p = 0.0025
NOX4 NADPH oxidase 4 0.05 1.32 p = 0.0061
NRP1 Neuropilin 1 0.17 0.82 n.s.
OLR1 Oxidized low density lipoprotein (lectin-like) receptor 1 0.04 0.02 n.s.
PDGFA Platelet-derived growth factor alpha polypeptide 0.36 0.12 p = 0.0480
PDGFRA Platelet-derived growth factor receptor, alpha polypeptide 1.66 7.31 n.s.
PDPN Podoplanin 0.09 3.36 p = 0.0061
PECAM1/CD31 Platelet/endothelial cell adhesion molecule 20.10 6.76 p = 0.0303
PTGS1 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.41 0.03 p = 0.0061
PTRF Polymerase I and transcript release factor 7.68 56.80 p = 0.0025
S1PR1 Sphingosine-1-phosphate receptor 1 0.15 0.76 p = 0.0172
SERPINF1 Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.19 6.45 p = 0.0061
STAB1 Stabilin 1 0.06 0.16 n.s.
TEK TEK tyrosine kinase, endothelial 0.11 1.17 p = 0.0043
TGFBR1 Transforming growth factor, beta receptor 1 0.05 0.38 p = 0.0025
THBS1 Thrombospondin 1 13.56 134.17 p = 0.0025
TIMP2 TIMP metallopeptidase inhibitor 2 9.32 54.78 p = 0.0025
TNFAIP2 Tumor necrosis factor, alpha-induced protein 2 0.08 0.01 n.s.
TYMP Thymidine phosphorylase 0.17 0.08 p = 0.0480
VCAM1 Vascular cell adhesion molecule 1 0.18 0.95 p = 0.0303
VEGFA Vascular endothelial growth factor A 3.38 36.05 p = 0.0025
VEGFC Vascular endothelial growth factor C 0.47 1.66 p = 0.0043
VEGFD/FIGF C-fos induced growth factor (vascular endothelial growth factor D) 0.01 0.23 n.s.
VEGFR1/FLT1 Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.15 0.73 p = 0.0061
VEGFR2/KDR Kinase insert domain receptor (a type III receptor tyrosine kinase) 0.26 3.48 p = 0.0061
VEGFR3/FLT4 Fms-related tyrosine kinase 4 0.08 0.10 n.s.