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Table 2 Histological assessment of proliferative and apoptotic activity and microvessel density in tumours collected after three weeks of treatment

From: Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors

 

Mitotic and proliferative activity

Apoptotic activity

Microvessel density

 

H & E

pHH3

Ki-67

H & E

Cl-PARP

CD31

Imatinib 50 mg/kg/BID

↑1.1

=

=

↓1.1

↑1.1

=

Imatinib 100 mg/kg/BID

↑1.1

↑1.1

↑1.1

↓1.3

↑1.3

=

Sunitinib 40 mg/kg/QD

=

↑1.2

↑1.1

↓1.4

↓1.3

↓1.4*

Regorafenib 30 mg/kg/QD

↑1.6*

↑1.5

↑1.1

↑1.1

↑1.4

↓1.4*

  1. Results are shown as fold changes in comparison with control, arrows indicate increase (↑) or decrease (↓). Mann–Whitney U test was performed for statistical assessment; *P < 0.05 (compared to control). H & E - haematoxylin and eosin staining, pHH3 - phospho-histone-H3 immunostaining; Cl-PARP - cleaved PARP immunostaining.
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Clinical Sarcoma Research

ISSN: 2045-3329