First line palliative chemotherapy in elderly patients with advanced soft tissue sarcoma

Table 2 Univariate analysis

Variable	Groups	Median overall survival in months (95% confidence interval)	Statistical significance, p
Sex	male	5.4 (3.1 – 7.7)	0.2
Sex	female	6.3 (3.5 – 9.1)	0.2
Age	<75 years	6.5 (4.6 – 8.4)	0.3
Age	>75 years	5.3 (3.9 – 6.6)	0.3
LDH	normal	7.1 (4.6 – 9.7)	0.3
LDH	high	5.4 (3.5 – 7.3)	0.3
Lymphocytes	normal	7.8 (5.9 – 9.5)	0.003*
Lymphocytes	low	3.7 (1.8 - 5.6)	0.003*
Sodium	normal	5.8 (4.4 – 7.2)	0.8
Sodium	low	8.2 (4.2 – 12.3)	0.8
Albumin	normal	7.7 (4.9 – 10.5)	0.003*
Albumin	low	3.1 (0.9 – 5.1)	0.003*
Haemoglobin	normal	8.1 (5.7 – 10.5)	0.02*
Haemoglobin	normal	5.3 (3.7 – 6.9)	0.02*
Grade	low	6.0 (4.5 – 7.6)	0.9
	intermediate	7.5 (6.8 – 8.1)
	high	6.3 (4.8 – 7.9)
Histological subtype	leiomyosarcoma	10.1 (3.9 – 16.4)	0.02*
	angiosarcoma	9.7 (6.4 – 12.9)
	undifferentiated	3.7 (1.2 – 6.2)
	other	5.1 (2.9 – 7.2)
Sites of visceral involvement	Lungs	5.7 (4.5 – 7.1)	0.2
	Liver	10.1 (0 – 30.9)
	bone	6.3 (0.9 – 11.7)
Age Adjusted Charlson Index	<3	9.6 (4.4 – 14.9)	0.03*
Age Adjusted Charlson Index	>3	5.6 (3.8 – 7.4)	0.03*

*significant factors in univariate analysis. Laboratory ranges for blood parameters were as follows; serum albumin (normal range 35 – 50 g/L), sodium (normal range 135 – 145 mmol/L) lymphocytes (normal range 1 – 3.5 × 10⁹/L), platelets (normal range 150 – 400 × 10⁹/L) , LDH (normal range 100 – 250 U/L) and haemoglobin (normal range, male 13 – 18 g/dL, female 11.5 – 15.5 g/dl).

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