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Table 7 Sarcoma advisory group guidelines—bone sarcomas

From: UK guidelines for the management of bone sarcomas

Sarcoma type

Category

1st line

2nd line

3rd line and other

Other high grade bone sarcomas including malignant fibrous histiocytoma, leiomyosarcoma, angiosarcoma, spindle cell sarcoma, dedifferentiated chondrosarcoma

 

Doxorubicin, cisplatin ± methotrexate [101]

Ifosfamide, etoposide  ± methotrexate [102]

Gemcitabine and docetaxel [103]

Giant cell tumour

Locally advanced unresectable/metastatic

Denosumab [175]

  

Chordoma

Locally advanced, unresectable or metastatic: non-dedifferentiated dedifferentiated

Imatinib [171] doxorubicin or doxorubicin and cisplatin [176]

Addition of sirolimus [170]

or Sunitinib [177]

 
  1. Taken from London and South East Sarcoma Network (LSESN) guidelines [98]