Table 2 Completed phase 1 (or pilot) trials of combination approaches that enrolled patients with sarcoma
Drug combination | Sarcoma tumor type (number enrolled) | Responsesa | Reference |
|---|---|---|---|
Trials with bevacizumab | |||
 Bevacizumab + pegylated SN-38 (EZN-2208) | STS (5) | SD (2) | [62] |
 Bevacizumab + bendamustine | Angiosarcoma (1) | None | [63] |
 Bevacizumab + irinotecan | RMS (1) | None | [64] |
 Bevacizumab + vincristine/irinotecan/temozolomide | STS (3); OS (2); ES (1) | SD (2) | [65] |
 Bevacizumab + vincristine/irinotecan/temozolomide | ES (2); RMS (1); Clear cell sarcoma (1) | CR (1); PR (1) | [42] |
 Bevacizumab + sorafenib + cyclophosphamide | OS (2); RMS (2); Other STS (4) | PR (1); SD (3) | [66] |
 Bevacizumab + gemcitabine/doxetaxel | STS (36) | CR (5); PR (6); SD (18) | [41] |
 Bevacizumab + ifosphamide/etoposide/carboplatin | STS (7); OS (3); Chondrosarcoma (2); Undifferentiated (1) | PR (4); SD (5) | [67] |
Trials with VEGFR and PDGFR inhibitors | |||
 Pazopanib + cisplatin | Sarcoma (5) | CR (1); SD (2) | [68] |
 Pazopanib + topotecan | STS (6); OS (2) | Unknown | [69] |
 Pazopanib + ifosfamide | Sarcoma (19) | PR (3) | [70] |
 Pazopanib + paclitaxel/carboplatin | OS (1); Giant cell tumor (1); Other sarcoma (1) | None | [71] |
 PDGFR inhibitor (CP-868,596) + docetaxel ± axitinib | ES (3); Other sarcoma (5) | SD (3) | [72] |
 Semaxanib + cisplatin/irinotecan | GIST (2); STS (1) | None | [73] |
 Sorafenib + irinotecan | OS (4); Synovial sarcoma (1); DSRCT (1); MPNST (1) | Unknown | [74] |
 Sunitinib + pemetrexed/carboplatin | Synovial sarcoma (1) | None | [75] |
 Sunitinib + gemcitabine | OS (1); STS (1) | SD (1) | [76] |
 Sunitinib + ifosfamide | ES (2); STS (6); Other sarcoma (7) | PR (2); SD (3) | [77] |
 Sunitinib + irinotecan | OS (1); STS (1) | None | [78] |
 Sunitinib + docetaxel | OS and STS (unknown) | None | [79] |
Trials with other antiangiogenic agents | |||
 Ombrabulin (AVE8062) + docetaxel | Muscle/bone tumors (5) | None | [80] |
 Thrombospondin-1 mimetic (ABT-510) + gemcitabine/cisplatin | Sarcoma (1) | None | [81] |
 Thrombospondin-1 mimetic (ABT-510) + 5-FU/leucovorin | Synovial sarcoma (1) | None | [82] |
 TNP-470 + paclitaxel/carboplatin | Sarcoma (2) | None | [83] |