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Table 2 Univariate and multivariate analysis

From: Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study

  Univariate (PFS) Univariate (OS) Multivariate (PFS) Multivariate (OS)
HR (95 % CI) p value HR (95 % CI) p value HR (95 % CI) p value HR (95 % CI) p value
Group
 MMP3 and pIGF1R− Reference   Reference   Reference   Reference  
 MMP3 or pIGF1R+ 1.39 (0.71–2.72) 0.34 1.10 (0.52–2.17) 0.95 1.53 (0.76–3.06) 0.23 1.67 (0.77–3.65) 0.20
 Albumin >median 0.73 (0.44–1.23) 0.24 0.82 (0.47–1.44) 0.49     
 Leucocytes >median 1.16 (0.73–1.85) 0.53 1.50 (0.90–2.49) 0.12     
 LDH >median 1.36 (0.84–2.21) 0.21 1.50 (0.89–2.55) 0.13     
 Age 0.99 (0.97–1.00) 0.33 0.99 (0.98–1.01) 0.51     
Kit mutation
 Exon 11/13 0.46 (0.28–0.76) 0.021 0.71 (0.41–1.21) 0.21 0.57 (0.33–0.97) 0.037   
 Other Reference   Reference      
ECOG
 PS 0 Reference   Reference   Reference   Reference  
 PS 1 1.13 (0.67–1.8) 0.65 1.17 (0.66–2.07) 0.59 1.74 (0.99–3.07) 0.055 2.00 (1.08–3.67) 0.026
 PS > 1 1.64 (0.73–3.68) 0.23 2.05 (0.88–4.76) 0.095 4.45 (1.85–10.76) 0.0009 5.25 (2.08–13.26) 0.0005
 Female 1.02 (0.64–1.63) 0.92 1.01 (0.61–1.67) 0.96     
Primary site
 Stomach 1.61 (1.00–2.59) 0.050 1.36 (0.82–2.27) 0.24     
 Others Reference   Reference      
Extension of disease         Ta
 1 metastatic organ Reference   Reference   Reference   Reference  
 2 or more metastatic organs 2.59 (1.52–4.42) 0.0005 2.56 (1.46–4.52) 0.0011 1.84 (1.03–3.27) 0.039 1.93 (1.03–3.62) 0.041
Surgery primary tumor
 Yes Reference   Reference      
 No 1.19 (0.51–2.75)   0.75 (0.27–2.08) 0.59    0.26 (0.09–0.76) 0.014
Disease-free interval   0.69       
 <24 months 13.4 (6.93–25.77) <0.0001 6.61 (3.72–11.79) <0.0001 18.87 (8.54–41.73) <0.0001 16.73 (7.97–35.13) <0.0001
 ≥24 months Reference   Reference   Reference   Reference