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Fig. 4 | Clinical Sarcoma Research

Fig. 4

From: IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas

Fig. 4

Variable levels of 5-hydroxymethylcytosine (5-hmC) and 5-methylcytosine (5-mC) in chondrosarcomas. Percentage of tumour cells positive for 5hmC (a, b) and 5mC (c, d) in IDH mutant versus IDH wildtype tumours (black bar indicates 50 µm). The percentage of 5-mC positive tumour cells was significantly higher in high grade chondrosarcomas as compared to low grade, which was independent of the IDH mutation status (e). Solitary chondrosarcomas showed significantly higher levels of 5mC compared to enchondromatosis related chondrosarcomas, independent of the histological grade (f)

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Clinical Sarcoma Research

ISSN: 2045-3329