Fig. 3

a Malignant OFMT pre-ILP biopsy, (HE, 40×). Densely packed cords of monomorphic cell with small round nuclei, high mitotic index. b Fluorescent in situ hybridization showing tetraploid cells showing unbalanced PHF1 gene translocation (green 5′). c Malignant OFMT post-ILP and chemotherapy, vital component (HE, 20×). The neoplasm is less densely cellulated and exhibits a variable morphology ranging from more rounded to spindle cell morphology. Mitotic activity is considerably reduced. d Malignant OFMT post-ILP and chemotherapy, non-vital component (HE, 20×). At the bottom of the image, a dense collagen sclerosis with haemosiderin deposition, ghost cells at the upper part, in between cell debris and isolated neoplastic cells with nuclei similarly to the viable component