The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma

Table 3 Predicted kinase inhibitors

Patient	Diagnosis	Database	Gene	Variant	Therapeutic
Pt1	Osteosarcoma	NCI match clinical trials	KIT	E142Q	Sunitinib
Pt1	Osteosarcoma	DSigDB FDA approved kinase inhibitors	KIT	E142Q	Imatinib, Sorafenib, Dasatanib, Sunitinib, Nilotinib, Pazopanib, Axitinib, Cabozantinib
Pt6	Ewing’s sarcoma	DSigDB FDA approved kinase inhibitors	ALK	C928fs	Crizotinib, Ceritinib
Pt7	Undifferentiated pleomorphic sarcoma	DSigDB FDA approved kinase inhibitors	ABL2	I471fs	Dasatinib
Pt8	Alveolar rhabdomyosarcoma	DSigDB FDA approved kinase inhibitors	NTRK1	G18E	Imatinib
Pt9	Leiomyosarcoma	DSigDB FDA approved kinase inhibitors	ALK	C928fs, F921L	Crizotinib, Ceritinib
Pt12	Undifferentiated pleomorphic sarcoma	DSigDB FDA approved kinase inhibitors	JAK2	S593F	Ruxolitinib

ISSN: 2045-3329