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Table 5 Comparison of potential actionable therapeutics between direct tumour analysis and PDX analysis

From: The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma

Diagnosis PDX-therapeutics identified (n) Novel in comparison to tumour (n) Tumour-therapeutics identified (n) P-value
Osteosarcoma 6 6 9 1.000
Osteosarcoma 24 22 11 0.019
Ewing’s sarcoma 16 15 13 0.161
Undifferentiated pleomorphic sarcoma 19 11 29 < 0.001
Alveolar rhabdomyosarcoma 6 5 3 0.219
Leiomyosarcoma 9 4 6 0.025
Metastatic angiosarcoma 11 11 10 1.000
  1. Each of the seven PDX samples are listed with their primary diagnosis. P-values were calculated using Fisher’s exact test of independence
  2. Italic values indicate significance of P-value (p < 0.05)