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Table 5 Comparison of potential actionable therapeutics between direct tumour analysis and PDX analysis

From: The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma

Diagnosis

PDX-therapeutics identified (n)

Novel in comparison to tumour (n)

Tumour-therapeutics identified (n)

P-value

Osteosarcoma

6

6

9

1.000

Osteosarcoma

24

22

11

0.019

Ewing’s sarcoma

16

15

13

0.161

Undifferentiated pleomorphic sarcoma

19

11

29

< 0.001

Alveolar rhabdomyosarcoma

6

5

3

0.219

Leiomyosarcoma

9

4

6

0.025

Metastatic angiosarcoma

11

11

10

1.000

  1. Each of the seven PDX samples are listed with their primary diagnosis. P-values were calculated using Fisher’s exact test of independence
  2. Italic values indicate significance of P-value (p < 0.05)
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Clinical Sarcoma Research

ISSN: 2045-3329