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Fig. 2 | Clinical Sarcoma Research

Fig. 2

From: Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors

Fig. 2

ae Significant upregulated gene members of the WNT signaling pathway in PTSMT. Note that non-significant (p = ns) differences between PTSMT and other tumors regarding WNT6 and WNT10A expression are related to non-detactable transcripts in several ALM, LMS and EHA (a, b). f Beta-catenin is bound and inactivated in a complex formation containing adenomatous polyposis coli gene (APC), glycogen synthase kinase 3 beta (GSK-3beta) and axin-1 (Axin). In the classical, beta-catenin-dependent WNT signaling pathway, members of WNT family bind to the frizzled class receptors (FZD) whereas beta-catenin is set free and initiates carcinogenesis via activation of MYC and Cyclin D2

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