Table 1 The IC₅₀ values and targets of the approved kinase inhibitors against PDGFRs

IC₅₀ values

 PDGFR-α [49]

2.5

2.6

2.4

1.0

13

20

 PDGFR-α [T674I] [50]

8500

4100

100

19

170

 PDGFR-α [V561D] [50]

9.1

2.9

15

5.6

14

21

 PDGFR-β [53]

68

1.1

60

34

5.7

42

Primary targets [53, 54]

Abl, PDGFR, Kit

Abl, Src

Kit, Abl, PDGFR

Raf, VEGFR, PDGFR, Kit, Flt3

PDGFR, VEGFR, Kit, Flt3

VEGFR, PDGFR, Kit

Secondary targets [53, 54]

Raf

PDGFR, Kit

FGFR