From: Report from the 4th European Bone Sarcoma Networking meeting: focus on osteosarcoma
Trial name | Title/description | Country | Study reference |
---|---|---|---|
GEIS 29 | Multicenter and prospective phase II trial with gemcitabine and rapamycin in second line of metastatic osteosarcoma | Spain | NCT02429973 |
GEIS 51 (Palbosarc) | Phase II multicenter trial of palbociclib in second line of advanced sarcomas with CDK4 overexpression | Spain | NCT03242382 |
GEIS 52 (InmunoSARC) | Phase I–II trial of sunitinib plus nivolumab after standard treatment in advanced soft tissue and bone sarcomas | Spain, Italy | NCT03277924 |
Sarcome13/0S2016 | Randomised phase-2 trial of mifamurtide (MEPACT®) combined with post-operative chemotherapy for newly diagnosed patients up to 50 years with high risk osteosarcoma (metastatic or localized disease with poor histologic response to neoadjuvant chemotherapy). | France | NA |
Regobone | A phase II study evaluating efficacy and safety of regorafenib in patients with metastatic bone sarcomas | France | NCT02389244 |
Cabone | Cabozantinib-s-malate in treating patients with relapsed osteosarcoma or Ewing sarcoma | France | NCT02243605 |
HOPE ITCC-035 | Study of lenvatinib in children and adolescents with refractory or relapsed solid malignancies and young adults with osteosarcoma | France, USA, Germany, Italy, Spain, UK | NCT02432274 |
PembroSARC | Combination of MK3475 and metronomic cyclophosphamide in patients with advanced sarcomas: multicentre phase II trial | France | NCT02406781 |
PROMO | A phase II study of pembrolizumab in patients with relapsed or metastatic osteosarcoma not eligible for curative surgery | Norway, Italy | NCT03013127 |
MAPPYACTS | Proof-of-concept study to stratify targeted therapies adapted to molecular profiling | France, Ireland, Israel, Italy, Spain | NCT02613962 |
ESMART | European proof-of-concept therapeutic stratification trial of molecular anomalies in relapsed or refractory tumors | France, Germany, Italy, Netherlands, Spain, UK | NCT02813135 |
Can cancer cells be found in blood samples from patients with bone sarcoma? | Enumeration of circulating tumour cells in patients with bone sarcomas: an observational study | UK | ISRCTN29619083 |