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Fig. 1 | Clinical Sarcoma Research

Fig. 1

From: Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)

Fig. 1

Mutational signature of 29 KIT-mutant GIST. a Average sequence context of somatic coding mutations for 40 GIST samples from WES. Signature displayed is according to the 96-substitution classification defined by the flanking 5′ and 3′ sequence adjacent to the mutated base. The mutation types are on the horizontal axis, vertical axis is the percentage of mutations attributed to each mutation type. Mutation signatures were normalized to the trinucleotide frequency of whole human genome. b Significantly mutated genes with q-value < 0.2 (corresponding p-value 0.0003) in KIT mutant GISTs. Main panel, variant type of significantly mutated genes found in each sample of our cohort of samples. Left panel represents the number of mutations of each gene. Right panel indicates the negative log10 of the q-value. Top panel represents the mutations per megabase (Mb) of the total coverage for each sample

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