Table 2 Carcinosarcoma of bone cases summary
Case | Age/gender | Primary site (s) | Histopathology | Metastasis | Treatment | Outcome |
|---|---|---|---|---|---|---|
Focal carcinosarcoma of the bone | ||||||
Ling and Steiner 1986 [6] | 68-female | Humerus | Chondrosarcoma and SCC | None | Resection | Disease free at 3 years |
Frydman et al. 1991 [7] | 42-male | Tibia | Lymphoma-like round cells, osteogenic sarcoma, and spindle cells | Lungs | Chemotherapy appropriate for a non-Hodgkin’s lymphoma | Succumbed to lung metastases over a year post-diagnosis |
Kramer et al. 1993 [8] | 13-male | Tibia | Osteogenic sarcoma and epithelial differentiation | None | Resection, neoadjuvant methotrexate, doxorubicin, and cisplatin | Disease free at 1 year |
Shiraishi et al. 2005 [9] | 53-male | Femur | Chondrosarcoma and SCC | Lung and soft tissue | Curettage, delayed resection, paraplatine 450 mg once a month for 6 months | Succumbed to pulmonary metastases 6 months post-diagnosis |
Ishida et al. 2014 [11] | 59-female | Fibula | Chondrosarcoma, SCC, and spindle cells | None | Resection | Disease free at 1 month |
Diffuse carcinosarcoma of the bone | ||||||
Paczos et al. 2009 [10] | 63-male | T10-L1 vertebrae, left iliac body | Poorly differentiated spindle cells | Multiple bony lesions | Radiotherapy, 5 courses of MAID protocol chemotherapy | Disease progression at 1 year |
Present case | 36-female | Bilateral humeri, pelvis, thoracic lumbar spine | Nondescript spindle cells | Extensive bony infiltration | Gemcitabine 600 mg/m2 and docetaxel 25 mg/m2, followed by salvage chemotherapy | Reduced tumor burden at 6 months, expired at 1 year post-diagnosis |