Table 1 Algorithms descriptions

1) At least two medical claims with an ICD-CM diagnosis code for STS at least 30 days apart in any position [13]

2) At least two medical claims of any type at least 30 days apart with an ICD-CM diagnosis code for STS AND at least one claim for the prescription or administration of NCCN-recommended systemic therapy for STS treatment following the first STS diagnosis and within the diagnostic period [15]

3) At least one medical claim of any type with an ICD-CM diagnosis code for any non-STS solid tumor cancer AND No medical claims for any hematological cancers during the diagnostic period AND At least one claim for the prescription or administration of STS NCCN recommended regimen (single therapy or combination therapy identified by a 21 day window following the first treatment) on or following the diagnosis date and within the diagnostic period

4) At least one medical claim of any type with an ICD-CM diagnosis code for retroperitoneal or peritoneal cancer AND No medical claims with an ICD-CM diagnosis code for gastrointestinal stromal tumors, osteosarcoma, Kaposi’s at any time during the diagnostic period AND No medical claims for reproductive cancers at any time during the diagnostic period AND No medical claims for excretory cancer at any time during the diagnostic period AND No medical claims for cardio/pulmonary cancer at any time during the diagnostic period AND At least one claim for the prescription or administration of STS NCCN recommended regimen on or following the diagnosis date and within the diagnostic period [16]

5a) At least one medical claim of any type with an ICD-CM diagnosis code for STS and a second claim for STS any time after

5b) At least one medical claim of any type with an ICD-CM diagnosis code for STS and at least one claim for the prescription or administration of NCCN-recommended systemic therapy for STS treatment any time after

5c) At least one medical claim of any type with an ICD-CM diagnosis code for STS and at least one claim for an STS surgery prior to or following

5d) At least one medical claim of any type with an ICD-CM diagnosis code for STS and at least one claim for an STS symptom (pain in limb, localized superficial swelling mass lump, neoplasm or uncertain behavior in skin) prior

5e) At least one medical claim of any type with an ICD-CM diagnosis code for STS and (a second claim for STS following, or STS treatment following, or STS surgery prior to or following, or an STS symptom prior to)

6a) At least one medical claim of any type with an ICD-CM diagnosis code for STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer and a second claim for STS anytime following

6b) At least one medical claim of any type with an ICD-CM diagnosis code for STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer and at least one claim for the prescription or administration of NCCN-recommended systemic therapy for STS treatment following

6c) At least one medical claim of any type with an ICD-CM diagnosis code for STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer and at least one claim for an STS surgery prior to or following

6d) At least one medical claim of any type with an ICD-CM diagnosis code for STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer and at least one claim for an STS symptom prior

6e) At least one medical claim of any type with an ICD-CM diagnosis code for STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer and (a second claim for STS anytime following, or STS treatment following, or STS surgery prior to or following, or an STS symptom prior)