Table 5 Algorithm test results
Short description | Algorithm | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
One STS diagnosis + a second STS diagnosis at least 30 days after the first | Algorithm 1 | 59.0 | 79.7 | 43.2 | 88.1 |
One STS diagnosis + a second STS diagnosis at least 30 days after the first + any NCCN recommended pharmacologic treatment for STS | Algorithm 2 | 16.4 | 97.0 | 58.8 | 81.6 |
One solid tumor cancer diagnosis + no evidence of hematologic cancer + an STS NCCN recommended single or combination regimen of pharmacologic treatment | Algorithm 3 | 2.2 | 99.5 | 1.5 | 99.7 |
One diagnosis of retroperitoneal or peritoneal cancer + no evidence of GIST, osteosarcoma, Kaposi’s + no reproductive cancer, no excretory cancer + no cardio/pulmonary cancer + an STS NCCN recommended single or combination regimen of pharmacologic treatment | Algorithm 4 | 15.4 | 97.0 | 24.0 | 95.0 |
One STS diagnosis + a second STS diagnosis any time after | Algorithm 5a | 67.4 | 71.9 | 38.5 | 89.4 |
One STS diagnosis + any STS NCCN recommended pharmacologic treatment | Algorithm 5b | 18.1 | 93.8 | 43.4 | 81.4 |
One STS diagnosis + surgery | Algorithm 5c | 59.1 | 54.0 | 25.2 | 83.5 |
One STS diagnosis + symptom | Algorithm 5d | 32.0 | 79.2 | 28.8 | 81.7 |
One STS diagnosis (+ second STS diagnosis or treatment or surgery or symptom) | Algorithm 5e | 80.3 | 42.3 | 26.7 | 89.1 |
One STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer diagnosis + STS diagnosis following | Algorithm 6a | 63.4 | 99.3 | 38.5 | 99.8 |
One STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer diagnosis + any STS NCCN recommended pharmacologic treatment | Algorithm 6b | 19.0 | 91.5 | 1.5 | 99.4 |
One STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer diagnosis + surgery | Algorithm 6c | 64.0 | 46.2 | 0.8 | 99.5 |
One STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer diagnosis + symptom | Algorithm 6d | 36.0 | 76.8 | 1.0 | 99.4 |
One STS, Ill-defined cancer, reproductive cancer, retroperitoneal or peritoneal cancer diagnosis (+ second STS diagnosis or treatment or surgery or symptom) | Algorithm 6e | 84.7 | 39.2 | 0.9 | 99.7 |