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Table 3 Multivariate analysis of complete cohort

From: Chemotherapy improves distant control in localized high-grade soft tissue sarcoma of the extremity/trunk

  

ALL

G3

G3 + MAI/MAID

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

Distant control

 Chemotherapy

Chemo(+) (vs. chemo(–))

0.368

0.77 (0.435–1.361)

0.037

0.475 (0.236–0.954)

0.01

0.333 (0.145–0.767)

 Sex

Male (vs. female)

0.172

1.405 (0.863–2.289)

0.142

1.501 (0.873–2.579)

0.229

1.387 (0.814–2.362)

 ECOG performance status

2+ (vs. 0–1)

< 0.001

3.521 (2.046–6.06)

< 0.001

3.654 (2.019–6.612)

< .001

3.146 (1.684–5.876)

 Age (categorical)

<70 (vs. ≥ 70 yoa)

0.819

1.063 (0.629–1.797)

0.083

1.659 (0.936–2.941)

0.096

1.634 (0.917–2.912)

 Pathologic tumor size

≥ 8 cm (vs. < 8 cm)

0.356

1.275 (0.761–2.136)

0.215

1.448 (0.807–2.598)

0.214

1.449 (0.807–2.603)

 Histology*

 

0.014

.

0.138

.

0.035

.

 Primary site*

 

0.759

.

0.962

.

0.98

.

Progression free survival

 Chemotherapy

Chemo(+) (vs. chemo(–))

0.581

0.876 (0.547–1.402)

0.101

0.629 (0.361–1.095)

0.047

0.52 (0.28–0.99)

 Sex

Male (vs. female)

0.149

1.326 (0.904–1.945)

0.21

1.306 (0.86–1.981)

0.201

1.32 (0.86–2.01)

 ECOG performance status

2 + (vs. 0–1)

< 0.001

3.32 (2.123–5.191)

< 0.001

2.75 (1.659–4.557)

< 0.001

2.83 (1.68–4.77)

 Age (categorical)

< 70 (vs. ≥ 70 yoa)

0.315

0.802 (0.521–1.234)

0.625

1.125 (0.702–1.802)

0.527

1.17 (0.72–1.89)

 Pathologic tumor size

≥ 8 cm (vs. < 8 cm)

0.788

1.058 (0.703–1.592)

0.592

1.135 (0.715–1.8)

0.533

1.16 (0.72–1.87)

 Histology*

 

0.019

.

0.078

.

0.098

.

 Primary site*

 

0.536

.

0.736

.

0.639

.

Overall survival

 Chemotherapy

Chemo(+) (vs. chemo(–))

0.759

0.909 (0.493–1.675)

0.481

0.772 (0.375–1.587)

0.171

0.564 (0.248–1.28)

 Sex

Male (vs. female)

0.266

1.337 (0.801–2.233)

0.247

1.389 (0.796–2.423)

0.181

1.464 (0.837–2.558)

 ECOG performance status

2+ (vs. 0–1)

0.001

2.523 (1.455–4.376)

0.003

2.46 (1.364–4.434)

0.015

2.179 (1.16–4.094)

 Age (categorical)

< 70 (vs. ≥ 70 yoa)

0.277

0.728 (0.411–1.29)

0.356

0.752 (0.41–1.378)

0.616

0.853 (0.459–1.586)

 Pathologic tumor size

≥ 8 cm (vs. < 8 cm)

0.947

0.982 (0.567–1.701)

0.631

0.866 (0.483–1.555)

0.835

0.938 (0.513–1.714)

 Histology*

 

0.037

.

0.292

.

0.103

.

 Primary site*

 

0.731

.

0.824

.

0.595

.

  1. * p-value designates the entire variables association with outcome on MVA
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Clinical Sarcoma Research

ISSN: 2045-3329