The role of prognostic nutritional index in the management of pulmonary sarcomatoid carcinoma

Table 2 Uni and multivariable survival analysis for various potential prognostic factors of overall and recurrence-free survival in PSC patients

OS	Univariate analysis			Multivariate analysis			RFS	Univariate analysis		Multivariate analysis
OS	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Age <= 60 vs. > 60	1.263	0.795–2.008	0.323				1.279	0.805–2.033	0.297
Sex Male vs. Female	0.778	0.445–1.358	0.377				0.765	0.438–1.335	0.345
Smoking history Yes vs. No	1.033	0.647–1.649	0.892				1.048	0.657–1.674	0.843
Alcohol abuse Yes vs. No	0.899	0.560–1.445	0.660				0.913	0.568–1.468	0.707
Tumor size > 5 vs. <=5 cm	1.811	1.109–2.956	0.018				1.776	1.090–2.896	0.021
Tumor stage T3–4 vs. T1–2	1.884	1.291–2.750	0.001				1.807	1.247–2.620	0.002
Tumor location Peripheral vs. Central	1.044	0.741–1.470	0.805				1.035	0.735–1.459	0.843
Nodal metastasis Positive vs. Negative	1.771	1.350–2.324	< 0.001				1.809	1.372–2.386	< 0.001
Pathological stage IIb–IIIc vs. Ia–IIa	1.546	1.313–1.820	< 0.001	1.432	1.210–1.695	< 0.001	1.539	1.304–1.817	< 0.001	1.373	1.160–1.625	< 0.001
Treatment modality			0.032			0.310			0.059			0.365
S + CT/S	0.473	0.268–0.835	0.010	0.639	0.356–1.145	0.132	0.508	0.289–0.893	0.019	0.673	0.379–1.197	0.178
S + CT + Targeted therapy/S	0.634	0.360–1.118	0.115	0.883	0.499–1.561	0.669	0.679	0.386–1.194	0.179	0.951	0.538–1.680	0.862
PNI	0.799	0.753–0.849	< 0.001	0.812	0.761–0.865	< 0.001	0.781	0.733–0.833	< 0.001	0.792	0.739–0.848	< 0.001

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