Fig. 1
From: Partial response to erlotinib in a patient with imatinib-refractory sacral chordoma
a, b Histological picture showing a tumor with chondromyxoid background. The tumor cells are arranged in cord like pattern with small nucleus and abundant cytoplasm. Few cells are large with abundant vacuolated cytoplasm called as physaliferous cells. c Immunostaining for S100 protein showing nuclear positivity in the tumor cells. d Immunostaining for Epithelial Membrane Antigen (EMA) showing membranous positivity in the tumor cells. e Immunostaining for epidermal growth factor receptor (EGFR) showing membranous positivity in the tumor cells. f MET gene amplification was positive by FISH