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Table 2 Analysis of cancer/testicular genes expression in melanoma and STBS cells

From: Cancer/testis antigens expression during cultivation of melanoma and soft tissue sarcoma cells

Quantitative CTA expression level, median, Q1–Q3, min–max
GeneMelanoma cellsSoft tissues and bones sarcoma cellsU-Mann–Whitney test, p-value (adjusted p-value)
GAGE2.05
0–0.73–3.33–6.24
0
0–0–1.20–3.94
< 0.001 (<0.001)
HAGE0
0–0–0–0.07
0
0–0–0–2.37
NY-ESO12.97
0–1.20–3.93–7.36
0
0–0–1.37–5.13
< 0.001 (0.003)
MAGEA11.86
0–0.69–3.27–4.49
0
0–0–0.61–4.06
< 0.001 (< 0.001)
PASD10.60
0–0.05–1.59–2.85
0
0–0–0.01–2.78
0.002 (0.013)
SCP10
0–0–0–0
0
0–0–0–0
SEMG10
0–0–0–1.18
0
0–0–0–0
SLLP10.02
0–0–0.09–2.69
0
0–0–0.01–1.07
0.049 (0.113)
SPANXA10
0–0–0–1.06
0
0–0–0–0
SSX10
0–0–0.01–4.50
0
0–0–0.01–9.31
0.837 (0.887)
PRAME4.86
2.27–4.06–5.53–6.40
0.01
0–0–2.11–2.73
< 0.001 (< 0.001)
The incidence of gene expression of the CTA
GenePositive cases/total (positive %)Fisher’ exact test, p-value (adjusted p-value)Odds ratio (STBS/melanoma)
Melanoma cellsSoft tissues and bones sarcoma cells
GAGE21/22 (95.5%)10/27 (37.04%)< 0.001 (< 0.001)0.028
HAGE1/22 (4.54%)5/27 (18.52%)4.773
NY-ESO121/22 (95.54%)15/27 (55.56%)0.003 (0.014)0.060
MAGEA120/22 (90.90%)10/27 (37.04%)< 0.001 (0.001)0.059
PASD117/22 (77.28%)11/27 (40.74%)0.019 (0.061)0.202
SCP10/22 (0%)0/27 (0%)
SEMG13/22 (13.63%)0/27 (0%)0
SLLP113/22 (59.10%)8/27 (29.63%)0.048 (0.113)0.292
SPANXA12/22 (9.09%)0/27 (0%)0
SSX110/22 (45.45%)14/27 (51.85%)0.776 (0.873)1.292
PRAME22/22 (100%)14/27 (51.85%)< 0.001 (0.001)0
  1. CTA expression levels were standardized with log1p function with logarithm’s base equals
  2. Statistically significant values are in italic