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  1. High-grade foci (grade 3 according to Broder’s grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outco...

    Authors: Alberto Righi, Anna Paioli, Angelo Paolo Dei Tos, Marco Gambarotti, Emanuela Palmerini, Manuela Cesari, Emanuela Marchesi, Davide Maria Donati, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2015 5:23

    Content type: Research

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  2. Pseudomyogenic hemangioendothelioma (PMH) is a recently described, indolent vascular tumor that usually presents in the distal extremities. PMH typically has a multi-focal presentation and can involve several ...

    Authors: Jason Joseph, Wei-lien Wang, Madhavi Patnana, Naveen Ramesh, Robert Benjamin, Shreyaskumar Patel and Vinod Ravi

    Citation: Clinical Sarcoma Research 2015 5:22

    Content type: Case Report

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  3. Gastrointestinal stromal tumors (GISTs) are commonly driven by activating mutations in either KIT or PDGFRA. Importantly, different mutations within these two genes can lead to very different levels of sensitivit...

    Authors: Andrew S. Brohl, Elizabeth G. Demicco, Karen Mourtzikos and Robert G. Maki

    Citation: Clinical Sarcoma Research 2015 5:21

    Content type: Case Report

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  4. Solitary fibrous tumors (SFT) of the retroperitoneum are rare spindle cell neoplasms, with a paucity of data on treatment outcomes. We hypothesized that surgical excision offered acceptable outcomes in SFTs.

    Authors: Rahul Rajeev, Mohit Patel, Thejus T. Jayakrishnan, Fabian M. Johnston, Meena Bedi, John Charlson and Kiran K. Turaga

    Citation: Clinical Sarcoma Research 2015 5:19

    Content type: Research

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  5. Venous thromboembolic co-morbidities can have a significant impact on treatment response, treatment options, quality of life, and ultimately, survival from cancer. There is a dearth of published information on...

    Authors: Sumitra Shantakumar, Alexandra Connelly-Frost, Monica G Kobayashi, Robert Allis and Li Li

    Citation: Clinical Sarcoma Research 2015 5:18

    Content type: Research

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  6. Chemotherapy in the multimodality treatment of osteosarcoma has improved survival. Reported outcomes on adult patients are limited. Poor necrosis rates post neoadjuvant chemotherapy (NAC) is considered an adve...

    Authors: G M O’Kane, K A Cadoo, E M Walsh, R Emerson, P Dervan, C O’Keane, B Hurson, G O’Toole, S Dudeney, E Kavanagh, S Eustace and D N Carney

    Citation: Clinical Sarcoma Research 2015 5:17

    Content type: Research

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  7. In vitro expanded mesenchymal stromal cells (MSCs) are increasingly used as experimental cellular therapy. However, there have been concerns regarding the safety of their use, particularly with regard to possi...

    Authors: Emilie P Buddingh, S Eriaty N Ruslan, Christianne M A Reijnders, Karoly Szuhai, Marieke L Kuijjer, Helene Roelofs, Pancras C W Hogendoorn, R Maarten Egeler, Anne-Marie Cleton-Jansen and Arjan C Lankester

    Citation: Clinical Sarcoma Research 2015 5:16

    Content type: Research

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  8. Tenosynovial giant cell tumour, diffuse type, also known under a variety of other terms including diffuse pigmented villonodular synovitis, tends to be locally aggressive and not infrequently can show multiple...

    Authors: A Righi, M Gambarotti, M Sbaraglia, T Frisoni, D Donati, D Vanel and A P Dei Tos

    Citation: Clinical Sarcoma Research 2015 5:15

    Content type: Case Report

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  9. Gemcitabine and docetaxel have been shown to be active in pre-treated relapsed leiomyosarcoma. This study investigated the combination as first line treatment in patients with unresectable locally advanced/met...

    Authors: Beatrice Seddon, Michelle Scurr, Robin L Jones, Zoe Wood, Cerys Propert-Lewis, Cyril Fisher, Adrienne Flanagan, Jonanthan Sunkersing, Roger A’Hern, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2015 5:13

    Content type: Research

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  10. Epithelioid hemangioendothelioma is a rare connective tissue tumor of vascular origin. It is most commonly found in young to middle aged women, and its clinical behavior is remakably variable from an indolent ...

    Authors: Olivia Bally, Louis Tassy, Bertrand Richioud, Anne-Valérie Decouvelaere, Jean-Yves Blay and Olfa Derbel

    Citation: Clinical Sarcoma Research 2015 5:12

    Content type: Case Report

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  11. To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role ...

    Authors: Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger von Eisenhart-Rothe and Melanie Straub

    Citation: Clinical Sarcoma Research 2015 5:11

    Content type: Short Report

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  12. The efficacy and toxicity of first line palliative chemotherapy for soft tissue sarcomas (STS) in the elderly is poorly described.

    Authors: Nadia Yousaf, Samuel Harris, Juan Martin-Liberal, Susannah Stanway, Mark Linch, Maria Ifijen, Omar Al Muderis, Komel Khabra, Cyril Fisher, Jonathan Noujaim, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2015 5:10

    Content type: Research

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  13. Conventional skeletal chondrosarcoma is a bone neoplasm, which is poorly sensitive to anthracyclines-based chemotherapy. We report on an 18-month-long tumour response to gemcitabine as single agent in a young ...

    Authors: Salvatore Provenzano, Nadia Hindi, Carlo Morosi, Mara Ghilardi, Paola Collini, Paolo G Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2015 5:9

    Content type: Case Report

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  14. Hormonal manipulation is sometimes recommended in the treatment of metastatic endometrial stromal sarcoma, but there are few data assessing the efficacy of endocrine therapies in this subtype of uterine sarcomas.

    Authors: Eirini Thanopoulou, Aleksandar Aleksic, Khin Thway, Komel Khabra and Ian Judson

    Citation: Clinical Sarcoma Research 2015 5:8

    Content type: Research

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  15. Recently a few cases of synovial sarcoma (SS) of the abdominal viscera have been reported, raising awareness about the potential for confusion between this entity and KIT-negative gastrointestinal stromal tumo...

    Authors: Salvatore Romeo, Sabrina Rossi, Marthelena Acosta Marín, Fabio Canal, Marta Sbaraglia, Licia Laurino, Guido Mazzoleni, Maria Cristina Montesco, Laura Valori, Marta Campo Dell’Orto, Andrea Gianatti, Alexander Joseph Lazar and Angelo Paolo Dei Tos

    Citation: Clinical Sarcoma Research 2015 5:7

    Content type: Research

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  16. Intra-osseous schwannoma is a rare mesenchymal tumor. Although, the head and neck region is one of the most common sites for schwannomas, its location at the skull bone is uncommon and accounted for less than ...

    Authors: Fadoua Rais, Naoual Benhmidou, Ghizlane Rais, Fadila Kouhen, Khadija Bellahamou, Hasna Loughlimi, Abdelhak Maghous, Sanae Elmejjaoui, Hanan Elkacemi, Tayeb Kebdani and Noureddine Benjaafar

    Citation: Clinical Sarcoma Research 2015 5:6

    Content type: Review

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  17. Solitary Fibrous Tumour (SFT) is a rare soft tissue neoplasm, described in several locations in the body. It is classified as intermediate malignant potential with low risk of metastasis and has a low tendency...

    Authors: Marco Maruzzo, Juan Martin-Liberal, Christina Messiou, Aisha Miah, Khin Thway, Rolyn Alvarado, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2015 5:5

    Content type: Research

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  18. Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Ganglioside GD2 has been previously found on the cell surface in various tumor types, including osteosarcomas.

    Authors: Vincent I Poon, Michael Roth, Sajida Piperdi, David Geller, Jonathan Gill, Erin R Rudzinski, Douglas S Hawkins and Richard Gorlick

    Citation: Clinical Sarcoma Research 2015 5:4

    Content type: Short Report

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  19. Pulmonary artery sarcoma (PAS) is a rare but aggressive malignancy that leads to heart failure and death without treatment. Here we reviewed the presentation and management of patients treated at a national ce...

    Authors: Han Hsi Wong, Ioannis Gounaris, Ann McCormack, Marius Berman, Dochka Davidson, Gail Horan, Joanna Pepke-Zaba, David Jenkins, Helena M Earl and Helen M Hatcher

    Citation: Clinical Sarcoma Research 2015 5:3

    Content type: Research

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  20. Tyrosine kinase inhibitors (TKI) have revolutionized the treatment of gastrointestinal

    Authors: Attila Kollàr, Marco Maruzzo, Christina Messiou, Elisabeth Cartwright, Aisha Miah, Juan Martin-Liberal, Khin Thway, Ellen McGrath, Alison Dunlop, Komel Khabra, Beatrice Seddon, Palma Dileo, Mark Linch, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2014 4:17

    Content type: Research

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  21. Liposarcomas represent the most common histological type of soft-tissue sarcomas (STS). Its main subgroups, WD/DD, is known to be poorly sensitive to chemotherapy, with few active agents, i.e., anthracyclines ...

    Authors: Roberta Sanfilippo, Rossella Bertulli, Andrea Marrari, Elena Fumagalli, Silvana Pilotti, Carlo Morosi, Antonella Messina, Angelo Paolo Dei Tos, Alessandro Gronchi and Paolo Giovanni Casali

    Citation: Clinical Sarcoma Research 2014 4:16

    Content type: Research

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  22. An increased risk of posttransplant malignancy has been consistently reported following various solid organ transplants. The malignancies most commonly encountered are non-melanoma skin cancers, carcinomas of ...

    Authors: Lea N Baer, David G Savage, Hanina H Hibshoosh and Kevin Kalinsky

    Citation: Clinical Sarcoma Research 2014 4:15

    Content type: Case Report

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  23. Recently, the phase III PALETTE study introduced pazopanib (Votrient®) as treatment for adult patients with locally advanced or metastatic non-liposarcoma soft tissue sarcoma after prior treatment with doxorub...

    Authors: Arie J Verschoor and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2014 4:14

    Content type: Case Report

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  24. Hemangiopericytoma is a rare disease entity of soft-tissue sarcoma (STS) that can be cured with surgical resection. In cases of inoperable recurrence or metastasis, palliative chemotherapy is indicated, though...

    Authors: Su Jin Lee, Seung Tae Kim, Se Hoon Park, Yoon La Choi, Jae Berm Park, Sung-Joo Kim and Jeeyun Lee

    Citation: Clinical Sarcoma Research 2014 4:13

    Content type: Case Report

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  25. We report multiple synchronous clear-cell chondrosarcomas in a 43-year-old patient. The patient had a lesion in the right proximal humerus and in the left femoral condyle. Bone scintigraphy revealed increased ...

    Authors: Marco Manfrini, Silvana Fiscina, Alberto Righi, Jorge M Montes and Daniel Vanel

    Citation: Clinical Sarcoma Research 2014 4:12

    Content type: Case Report

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  26. The majority of patients with chondrosarcoma of bone have an excellent overall survival after local therapy. However, in case of unresectable locally advanced or metastatic disease the outcome is poor and limi...

    Authors: Annemiek M van Maldegem, Judith VMG Bovée and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2014 4:11

    Content type: Research

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  27. Acquired resistance to tyrosine kinase inhibitors (TKIs) in gastrointestinal stromal tumours (GISTs) is most commonly caused by secondary KIT or PDGFRA mutations. In this study we characterize a newly established...

    Authors: Thomas Van Looy, Yemarshet Kelemework Gebreyohannes, Agnieszka Wozniak, Jasmien Cornillie, Jasmien Wellens, Haifu Li, Ulla Vanleeuw, Giuseppe Floris, Maria Debiec-Rychter, Raf Sciot and Patrick Schöffski

    Citation: Clinical Sarcoma Research 2014 4:10

    Content type: Research

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  28. Intragenic deletions of the dystrophin-encoding and muscular dystrophy-associated DMD gene have been recently described in gastrointestinal stromal tumor (GIST), rhabdomyosarcoma (RMS) and leiomyosarcoma (LMS). W...

    Authors: Maria A Pantaleo, Annalisa Astolfi, Milena Urbini, Fabio Fuligni, Maristella Saponara, Margherita Nannini, Cristian Lolli, Valentina Indio, Donatella Santini, Giorgio Ercolani, Giovanni Brandi, Antonio D Pinna and Guido Biasco

    Citation: Clinical Sarcoma Research 2014 4:9

    Content type: Short Report

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  29. Dermatofibrosarcoma Protuberans (DFSP) is a rare skin tumor, characterized by frequent local recurrence but is seldom metastatic. It is histologically characterized by storiform arrangement of spindle cells. C...

    Authors: Mashaal Dhir, David G Crockett, Todd M Stevens, Peter T Silberstein, William J Hunter and Jason M Foster

    Citation: Clinical Sarcoma Research 2014 4:8

    Content type: Case Report

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  30. We retrospectively reviewed data from nine pre-treated metastatic desmoplastic small round cell tumour (DSRCT) patients who received pazopanib.

    Authors: Anna Maria Frezza, Charlotte Benson, Ian R Judson, Saskia Litiere, Sandrine Marreaud, Stefan Sleijfer, Jean-Yves Blay, Raz Dewji, Cyril Fisher, Winette van der Graaf and Larry Hayward

    Citation: Clinical Sarcoma Research 2014 4:7

    Content type: Research

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  31. This is the report of the 2nd Joint ENCCA/EuroSARC European Bone Sarcoma Network Meeting held in Leiden, The Netherlands, on 26-27 September 2013, bringing together preclinical and clinical investigators on bone ...

    Authors: Jakob K Anninga, Anne-Marie Cleton-Jansen, Bass Hassan, M Fernanda Amary, Daniel Baumhoer, Jean-Yves Blay, Laurence Brugieres, Stefano Ferrari, Heribert Jürgens, Beate Kempf-Bielack, Heinrich Kovar, Ola Myklebost, Michaela Nathrath, Piero Picci, Peter Riegman, Marco W Schilham…

    Citation: Clinical Sarcoma Research 2014 4:4

    Content type: Meeting Report

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  32. Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT), are rare complications following organ/stem cell transplantation. Despite the mainly benign behaviour of PTSMT, alternative th...

    Authors: Danny Jonigk, Nicole Izykowski, Lavinia Maegel, Eileen Schormann, Britta Ludewig, Hans Kreipe and Kais Hussein

    Citation: Clinical Sarcoma Research 2014 4:1

    Content type: Research

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  33. Extraskeletal myxoid chondrosarcoma (EMC) is a rare subgroup within soft tissue sarcomas. Its sensitivity to chemotherapy is reported to be low.

    Authors: Silvia Stacchiotti, Gian Paolo Dagrada, Roberta Sanfilippo, Tiziana Negri, Isabella Vittimberga, Stefano Ferrari, Federica Grosso, Gaetano Apice, Marco Tricomi, Chiara Colombo, Alessandro Gronchi, Angelo P Dei Tos, Silvana Pilotti and Paolo G Casali

    Citation: Clinical Sarcoma Research 2013 3:16

    Content type: Research

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  34. Data suggests that males experience less toxicity and poorer survival than females treated for Ewing’s sarcoma. We instituted an intra-patient dose escalation (DE) policy with Vincristine/Doxorubicin/Cyclophos...

    Authors: Jeremy Lewin, Samantha Wieringa, Marnie Collins, Jayesh Desai, Lisa Orme, Senthil Lingaratnam and David M Thomas

    Citation: Clinical Sarcoma Research 2013 3:15

    Content type: Research

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  35. Desmoplastic small round cell tumour (DSRCT) is a rare but frequently fatal sarcoma, and many of its characteristics still require further clarification.

    Authors: Han Hsi Wong, Helen M Hatcher, Charlotte Benson, Omar Al-Muderis, Gail Horan, Cyril Fisher, Helena M Earl and Ian Judson

    Citation: Clinical Sarcoma Research 2013 3:14

    Content type: Research

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  36. Desmoid tumours/aggressive fibromatosis (DT/AF) are infrequent soft-tissue neoplasms. They usually behave as indolent diseases. However, they may grow locally infiltrating or compressing adjacent structures. T...

    Authors: Juan Martin-Liberal, Charlotte Benson, Heather McCarty, Khin Thway, Christina Messiou and Ian Judson

    Citation: Clinical Sarcoma Research 2013 3:13

    Content type: Case Report

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  37. Gastrointestinal stromal tumors are rare soft tissue sarcomas that typically develop from mesenchymal cells with acquired gain-in-function mutations in KIT or PDGFRA oncogenes. These somatic mutations have been w...

    Authors: Katie M O’Brien, Irene Orlow, Cristina R Antonescu, Karla Ballman, Linda McCall, Ronald DeMatteo and Lawrence S Engel

    Citation: Clinical Sarcoma Research 2013 3:12

    Content type: Research

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  38. The study aimed to examine attitudes of individuals diagnosed with sarcoma and their family members towards genetics, genomic research and incidental information arising as a result of participating in genetic...

    Authors: Mary-Anne Young, Amy Herlihy, Gillian Mitchell, David M Thomas, Mandy Ballinger, Kathy Tucker, Craig R Lewis, Susan Neuhaus and Jane Halliday

    Citation: Clinical Sarcoma Research 2013 3:11

    Content type: Research

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  39. MSCs are hypothesized to potentially give rise to sarcomas after transformation and therefore serve as a good model to study sarcomagenesis. Both spontaneous and induced transformation of MSCs have been report...

    Authors: Wei Xiao, Alexander B Mohseny, Pancras C W Hogendoorn and Anne-Marie Cleton-Jansen

    Citation: Clinical Sarcoma Research 2013 3:10

    Content type: Review

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  40. Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT) are rare complications. In our previous molecular analysis, we have evaluated the expression of regulatory microRNA which are k...

    Authors: Danny Jonigk, Nicole Izykowski, Lavinia Maegel, Eileen Schormann, Britta Maecker-Kolhoff, Florian Laenger, Hans Kreipe and Kais Hussein

    Citation: Clinical Sarcoma Research 2013 3:9

    Content type: Research

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  41. Pigmented villonodular synovitis (PVNS) is a rare locally aggressive tumor. PVNS is characterized in most cases by a specific t(1;2) translocation, which fuses the colony stimulating factor-1 (CSF1) gene to the c...

    Authors: Silvia Stacchiotti, Flavio Crippa, Antonella Messina, Silvana Pilotti, Alessandro Gronchi, Jean Y Blay and Paolo G Casali

    Citation: Clinical Sarcoma Research 2013 3:8

    Content type: Case Report

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  42. Patients with advanced solitary fibrous tumors (SFTs) have a poor prognosis; treatment options for recurrent disease are particularly limited. Several novel targeted agents have recently shown promise against ...

    Authors: Min S Park, Vinod Ravi, Anthony Conley, Shreyaskumar R Patel, Jonathan C Trent, Dina C Lev, Alexander J Lazar, Wei-Lien Wang, Robert S Benjamin and Dejka M Araujo

    Citation: Clinical Sarcoma Research 2013 3:7

    Content type: Research

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  43. We surveyed the natural history of bone metastases in patients affected by soft tissue sarcoma (STS).

    Authors: Bruno Vincenzi, Anna Maria Frezza, Gaia Schiavon, Daniele Santini, Palma Dileo, Marianna Silletta, Delia Delisi, Francesco Bertoldo, Giuseppe Badalamenti, Giacomo Giulio Baldi, Stefania Zovato, Rossana Berardi, Marco Tucci, Franco Silvestris, Angelo Paolo Dei Tos, Roberto Tirabosco…

    Citation: Clinical Sarcoma Research 2013 3:6

    Content type: Research

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