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  2. Osteosarcoma is the most common form of bone cancer. Pivotal insight into the genes involved in human osteosarcoma has been provided by the study of rare familial cancer predisposition syndromes. Three kindred...

    Authors: Alvin JM Ng, Anthony J Mutsaers, Emma K Baker and Carl R Walkley

    Citation: Clinical Sarcoma Research 2012 2:19

    Content type: Review

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  3. Sarcomas were one of the first solid cancers to be linked to ionizing radiation exposure. We reviewed the current evidence on this relationship, focusing particularly on the studies that had individual estimat...

    Authors: Amy Berrington de Gonzalez, Alina Kutsenko and Preetha Rajaraman

    Citation: Clinical Sarcoma Research 2012 2:18

    Content type: Review

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  6. Children diagnosed with the hereditary form of retinoblastoma (Rb), a rare eye cancer caused by a germline mutation in the RB1 tumor suppressor gene, have excellent survival, but face an increased risk of bone an...

    Authors: Ruth A Kleinerman, Sara J Schonfeld and Margaret A Tucker

    Citation: Clinical Sarcoma Research 2012 2:15

    Content type: Review

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  7. Sarcomas account for over 20% of all pediatric solid malignant cancers and less than 1% of all adult solid malignant cancers. The vast majority of diagnosed sarcomas will be soft tissue sarcomas, while maligna...

    Authors: Zachary Burningham, Mia Hashibe, Logan Spector and Joshua D Schiffman

    Citation: Clinical Sarcoma Research 2012 2:14

    Content type: Review

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  8. To evaluate tolerability and maintenance of dose intensity of 2 weekly treatment with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, etoposide (VDC/IE) in patients with advanced small ...

    Authors: Jeremy Whelan, Atia Khan, Anand Sharma, Christian Rothermundt, Palma Dileo, Maria Michelagnoli, Beatrice Seddon and Sandra Strausss

    Citation: Clinical Sarcoma Research 2012 2:12

    Content type: Research

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  9. Recombinant erythropoietin for the anaemia of patients with advanced Gastrointestinal Stromal Tumours (GIST) receiving imatinib : an active agent only in non progressive patients.

    Authors: Florence Duffaud, Caroline Even, Isabelle Ray-Coquard, Emmanuelle Bompas, Thanh Khoa-Huynh, Sebastien Salas, Philippe Cassier, Armelle Dufresne, Sylvie Bonvalot, Francoise Ducimetiere, Axel Le Cesne and Jean-Yves Blay

    Citation: Clinical Sarcoma Research 2012 2:11

    Content type: Research

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  10. Phenol is widely used for years as local adjuvant treatment for bone tumours. Despite its use for a long time, no information is available about the local concentration of phenol that is achieved in an individ...

    Authors: Suzan HM Verdegaal, Jan den Hartigh, Pancras CW Hogendoorn, Hugo FG Brouwers and Antonie HM Taminiau

    Citation: Clinical Sarcoma Research 2012 2:10

    Content type: Research

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  11. Osteosarcoma is the most common primary high-grade bone tumor in both adolescents and children. Early tumor detection is key to ensuring effective treatment. Serum marker discovery and validation for pediatric...

    Authors: Yulia A Savitskaya, Genaro Rico-Martínez, Luis Miguel Linares-González, Ernesto Andrés Delgado-Cedillo, René Téllez-Gastelum, Alfonso Benito Alfaro-Rodríguez, Antonio Redón-Tavera and José Clemente Ibarra-Ponce de León

    Citation: Clinical Sarcoma Research 2012 2:9

    Content type: Review

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  12. Ewing sarcoma patients have a poor prognosis despite multimodal therapy. Integration of combination immunotherapeutic strategies into first-/second-line regimens represents promising treatment options, particu...

    Authors: Dagmar Berghuis, Marco W Schilham, Hanneke I Vos, Susy J Santos, Stephan Kloess, Emilie P Buddingh', R Maarten Egeler, Pancras CW Hogendoorn and Arjan C Lankester

    Citation: Clinical Sarcoma Research 2012 2:8

    Content type: Research

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  13. Ewing Sarcoma is the second most common primary bone sarcoma with 900 new diagnoses per year in Europe (EU27). It has a poor survival rate in the face of metastatic disease, with no more than 10% survival of t...

    Authors: Annmeik M van Maldegem, Pancras CW Hogendoorn and Andrew B Hassan

    Citation: Clinical Sarcoma Research 2012 2:7

    Content type: Short Report

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  15. High grade primary bone sarcomas are rare cancers that affect mostly children and young adults. Osteosarcoma and Ewing sarcoma are the most common histological subtypes in this age group, with current multimod...

    Authors: Annemiek M van Maldegem, Aparna Bhosale, Hans J Gelderblom, Pancras CW Hogendoorn and Andrew B Hassan

    Citation: Clinical Sarcoma Research 2012 2:5

    Content type: Short Report

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  16. Dermatofibrosarcoma protuberans (DFSP) is a relatively common soft-tissue tumor. A more aggressive appearing fibrosarcoma may arise in DFSP, changing its biological behavior. CD34 and apolipoprotein-D are high...

    Authors: Emanuela Palmerini, Marco Gambarotti, Eric L Staals, Licciana Zanella, Gabriela Sieberova, Alessandra Longhi, Marilena Cesari, Stefano Bonarelli, Piero Picci, Pietro Ruggieri, Marco Alberghini and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2012 2:4

    Content type: Research

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  17. Desmoplastic small round cell tumour is a rare malignant tumour with a male to female ratio of 4:1. It manifests mostly at serosal sites. Here we present a case of a 28-year-old male patient, who presented wit...

    Authors: Vincent PM Cliteur, Károly Szuhai, Hans J Baelde, Jurriaan van Dam, Hans Gelderblom and Pancras CW Hogendoorn

    Citation: Clinical Sarcoma Research 2012 2:3

    Content type: Case Report

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  18. Myxoid liposarcoma (MLS) is a soft tissue sarcoma with adipocytic differentiation characterized by a unique chromosome rearrangement, t(12;16)(q13;p11). The exact efficacy of chemotherapy in MLS has not been c...

    Authors: Daniela Katz, Piyaporn Boonsirikamchai, Haeson Choi, Alexander J Lazar, Wei-Lein Wang, Lianchun Xiao, Min S Park, Vinod Ravi, Robert S Benjamin and Dejka M Araujo

    Citation: Clinical Sarcoma Research 2012 2:2

    Content type: Research

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  20. The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a seri...

    Authors: Fredrik Mertens, Salvatore Romeo, Judith VMG Bovée, Roberto Tirabosco, Nick Athanasou, Marco Alberghini, Pancras CW Hogendoorn, Angelo P Dei Tos, Raf Sciot, Henryk A Domanski, Kristina Åström, Nils Mandahl and Maria Debiec-Rychter

    Citation: Clinical Sarcoma Research 2011 1:10

    Content type: Research

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  21. A 35-year-old female presented with pain and swelling of the distal left radius. A diagnosis of Ewing sarcoma was made and she underwent neoadjuvant chemotherapy and surgery. Macroscopic viable areas remained ...

    Authors: Noemie Vanel, Victoire Vierling, Jennifer Kreshak, Marco Gambarotti, Stefania Cocchi, Cristina Tranfaglia and Daniel Vanel

    Citation: Clinical Sarcoma Research 2011 1:9

    Content type: Case Report

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  22. Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in lipos...

    Authors: Eva W Stratford, Russell Castro, Anna Wennerstrøm, Ruth Holm, Else Munthe, Silje Lauvrak, Bodil Bjerkehagen and Ola Myklebost

    Citation: Clinical Sarcoma Research 2011 1:8

    Content type: Research

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  23. Leiomyosarcoma of deep soft tissues of the extremities is a rare malignant tumour treated primarily by surgery. The incidence of local recurrence and lymph node metastasis is uncertain and it is not known whet...

    Authors: Michael J Lamyman, Henk P Giele, Paul Critchley, Duncan Whitwell, Max Gibbons and Nicholas A Athanasou

    Citation: Clinical Sarcoma Research 2011 1:7

    Content type: Research

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  25. Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and diffe...

    Authors: Danielle Meijer, Hans Gelderblom, Marcel Karperien, Anne-Marie Cleton-Jansen, Pancras CW Hogendoorn and Judith VMG Bovée

    Citation: Clinical Sarcoma Research 2011 1:5

    Content type: Research

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  26. Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosi...

    Authors: Barbara Dewaele, Francesca Maggiani, Giuseppe Floris, Michèle Ampe, Vanessa Vanspauwen, Agnieszka Wozniak, Maria Debiec-Rychter and Raf Sciot

    Citation: Clinical Sarcoma Research 2011 1:4

    Content type: Research

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  28. Parosteal osteosarcoma is a well-differentiated variant of osteosarcoma that affects the surface of the bone. The imaging pattern is very typical. We report two cases mimicking an osteochondroma, radiologicall...

    Authors: Zafiria G Papathanassiou, Marco Alberghini, Philippe Thiesse, Marco Gambarotti, Giuseppe Bianchi, Cristina Tranfaglia and Daniel Vanel

    Citation: Clinical Sarcoma Research 2011 1:2

    Content type: Research

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  29. Welcome to Clinical Sarcoma Research a new open access, online medical journal providing a forum for clinical knowledge on rare solid cancers - sarcomas. We believe there is a vacuum, which this effort may hope t...

    Authors: Paolo G Casali and Angelo P Dei Tos

    Citation: Clinical Sarcoma Research 2011 1:1

    Content type: Editorial

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  • ISSN: 2045-3329 (electronic)

Clinical Sarcoma Research

ISSN: 2045-3329