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  1. Desmoid tumours/aggressive fibromatosis (DT/AF) are infrequent soft-tissue neoplasms. They usually behave as indolent diseases. However, they may grow locally infiltrating or compressing adjacent structures. T...

    Authors: Juan Martin-Liberal, Charlotte Benson, Heather McCarty, Khin Thway, Christina Messiou and Ian Judson
    Citation: Clinical Sarcoma Research 2013 3:13
  2. Gastrointestinal stromal tumors are rare soft tissue sarcomas that typically develop from mesenchymal cells with acquired gain-in-function mutations in KIT or PDGFRA oncogenes. These somatic mutations have been w...

    Authors: Katie M O’Brien, Irene Orlow, Cristina R Antonescu, Karla Ballman, Linda McCall, Ronald DeMatteo and Lawrence S Engel
    Citation: Clinical Sarcoma Research 2013 3:12
  3. The study aimed to examine attitudes of individuals diagnosed with sarcoma and their family members towards genetics, genomic research and incidental information arising as a result of participating in genetic...

    Authors: Mary-Anne Young, Amy Herlihy, Gillian Mitchell, David M Thomas, Mandy Ballinger, Kathy Tucker, Craig R Lewis, Susan Neuhaus and Jane Halliday
    Citation: Clinical Sarcoma Research 2013 3:11
  4. MSCs are hypothesized to potentially give rise to sarcomas after transformation and therefore serve as a good model to study sarcomagenesis. Both spontaneous and induced transformation of MSCs have been report...

    Authors: Wei Xiao, Alexander B Mohseny, Pancras C W Hogendoorn and Anne-Marie Cleton-Jansen
    Citation: Clinical Sarcoma Research 2013 3:10
  5. Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT) are rare complications. In our previous molecular analysis, we have evaluated the expression of regulatory microRNA which are k...

    Authors: Danny Jonigk, Nicole Izykowski, Lavinia Maegel, Eileen Schormann, Britta Maecker-Kolhoff, Florian Laenger, Hans Kreipe and Kais Hussein
    Citation: Clinical Sarcoma Research 2013 3:9
  6. Pigmented villonodular synovitis (PVNS) is a rare locally aggressive tumor. PVNS is characterized in most cases by a specific t(1;2) translocation, which fuses the colony stimulating factor-1 (CSF1) gene to the c...

    Authors: Silvia Stacchiotti, Flavio Crippa, Antonella Messina, Silvana Pilotti, Alessandro Gronchi, Jean Y Blay and Paolo G Casali
    Citation: Clinical Sarcoma Research 2013 3:8
  7. Patients with advanced solitary fibrous tumors (SFTs) have a poor prognosis; treatment options for recurrent disease are particularly limited. Several novel targeted agents have recently shown promise against ...

    Authors: Min S Park, Vinod Ravi, Anthony Conley, Shreyaskumar R Patel, Jonathan C Trent, Dina C Lev, Alexander J Lazar, Wei-Lien Wang, Robert S Benjamin and Dejka M Araujo
    Citation: Clinical Sarcoma Research 2013 3:7
  8. We surveyed the natural history of bone metastases in patients affected by soft tissue sarcoma (STS).

    Authors: Bruno Vincenzi, Anna Maria Frezza, Gaia Schiavon, Daniele Santini, Palma Dileo, Marianna Silletta, Delia Delisi, Francesco Bertoldo, Giuseppe Badalamenti, Giacomo Giulio Baldi, Stefania Zovato, Rossana Berardi, Marco Tucci, Franco Silvestris, Angelo Paolo Dei Tos, Roberto Tirabosco…
    Citation: Clinical Sarcoma Research 2013 3:6
  9. We explore the pattern of late recurrence (LR) in solitary fibrous tumor (SFT), focusing on histopathologic characteristics, clinical presentation and patients (pts) outcome.

    Authors: Giacomo G Baldi, Silvia Stacchiotti, Valentina Mauro, Angelo P Dei Tos, Alessandro Gronchi, Ugo Pastorino, Leonardo Duranti, Salvatore Provenzano, Andrea Marrari, Michela Libertini, Silvana Pilotti and Paolo G Casali
    Citation: Clinical Sarcoma Research 2013 3:4
  10. The systemic treatment of malignant endometrial stromal tumors (EST) is not well established. A few reports describe objective responses to imatinib, which suggest a novel therapeutic strategy for these tumors...

    Authors: Ruth Sardinha, Teresa Hernández, Susana Fraile, Francesc Tresserra, August Vidal, Maria Carmén Gómez, Aurora Astudillo, Nieves Hernández, Javier Saenz de Santamaría, Jaume Ordi, Luis Gonçalves, Rafael Ramos, Carmen Balañá and Enrique de Álava
    Citation: Clinical Sarcoma Research 2013 3:3
  11. Ewing sarcoma (ES) is a high-grade malignant primary round cell tumour of bone in which there is commonly extension into extraosseous soft tissues at the time of diagnosis. This report details the clinical, ra...

    Authors: Takeshi G Kashima, Nimali G Gamage, Uta Dirksen, Christopher L M H Gibbons, Simon J Ostlere and Nicholas A Athanasou
    Citation: Clinical Sarcoma Research 2013 3:2
  12. Trabectedin and thioglitazones have been documented to induce adipocytic maturation in myxoid liposarcoma; we have noted this in our experience as well. Intriguingly, we have also encountered this same phenome...

    Authors: Wei-Lien Wang, Daniela Katz, Dejka M Araujo, Vinod Ravi, Joseph A Ludwig, Jonathan C Trent, Shreyaskumar R Patel, Patrick P Lin, Ashleigh Guadagnolo, Dolores Lòpez-Terrada, Angelo Paola dei Tos, Valerie O Lewis, Dina Lev, Raphael E Pollock, Gunar K Zagars, Robert S Benjamin…
    Citation: Clinical Sarcoma Research 2012 2:25
  13. Chemokine receptor CXCR4, together with its ligand CXCL12, plays critical roles in cancer progression, including growth, metastasis and angiogenesis. Ewing sarcoma is a sarcoma with poor prognosis despite curr...

    Authors: Dagmar Berghuis, Marco W Schilham, Susy J Santos, Suvi Savola, Helen J Knowles, Uta Dirksen, Karl-Ludwig Schaefer, Jukka Vakkila, Pancras CW Hogendoorn and Arjan C Lankester
    Citation: Clinical Sarcoma Research 2012 2:24
  14. Extraskeletal myxoid chondrosarcoma (EMCS) is a rare soft tissue sarcoma of uncertain differentiation, characterized in most cases by a translocation that results in the fusion protein EWSR1-CHN (the latter even ...

    Authors: Silvia Stacchiotti, Gian Paolo Dagrada, Carlo Morosi, Tiziana Negri, Antonella Romanini, Silvana Pilotti, Alessandro Gronchi and Paolo G Casali
    Citation: Clinical Sarcoma Research 2012 2:22
  15. Osteosarcoma is the most common form of bone cancer. Pivotal insight into the genes involved in human osteosarcoma has been provided by the study of rare familial cancer predisposition syndromes. Three kindred...

    Authors: Alvin JM Ng, Anthony J Mutsaers, Emma K Baker and Carl R Walkley
    Citation: Clinical Sarcoma Research 2012 2:19
  16. Sarcomas were one of the first solid cancers to be linked to ionizing radiation exposure. We reviewed the current evidence on this relationship, focusing particularly on the studies that had individual estimat...

    Authors: Amy Berrington de Gonzalez, Alina Kutsenko and Preetha Rajaraman
    Citation: Clinical Sarcoma Research 2012 2:18
  17. Children diagnosed with the hereditary form of retinoblastoma (Rb), a rare eye cancer caused by a germline mutation in the RB1 tumor suppressor gene, have excellent survival, but face an increased risk of bone an...

    Authors: Ruth A Kleinerman, Sara J Schonfeld and Margaret A Tucker
    Citation: Clinical Sarcoma Research 2012 2:15
  18. Sarcomas account for over 20% of all pediatric solid malignant cancers and less than 1% of all adult solid malignant cancers. The vast majority of diagnosed sarcomas will be soft tissue sarcomas, while maligna...

    Authors: Zachary Burningham, Mia Hashibe, Logan Spector and Joshua D Schiffman
    Citation: Clinical Sarcoma Research 2012 2:14
  19. To evaluate tolerability and maintenance of dose intensity of 2 weekly treatment with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, etoposide (VDC/IE) in patients with advanced small ...

    Authors: Jeremy Whelan, Atia Khan, Anand Sharma, Christian Rothermundt, Palma Dileo, Maria Michelagnoli, Beatrice Seddon and Sandra Strausss
    Citation: Clinical Sarcoma Research 2012 2:12
  20. Recombinant erythropoietin for the anaemia of patients with advanced Gastrointestinal Stromal Tumours (GIST) receiving imatinib : an active agent only in non progressive patients.

    Authors: Florence Duffaud, Caroline Even, Isabelle Ray-Coquard, Emmanuelle Bompas, Thanh Khoa-Huynh, Sebastien Salas, Philippe Cassier, Armelle Dufresne, Sylvie Bonvalot, Francoise Ducimetiere, Axel Le Cesne and Jean-Yves Blay
    Citation: Clinical Sarcoma Research 2012 2:11
  21. Phenol is widely used for years as local adjuvant treatment for bone tumours. Despite its use for a long time, no information is available about the local concentration of phenol that is achieved in an individ...

    Authors: Suzan HM Verdegaal, Jan den Hartigh, Pancras CW Hogendoorn, Hugo FG Brouwers and Antonie HM Taminiau
    Citation: Clinical Sarcoma Research 2012 2:10
  22. Osteosarcoma is the most common primary high-grade bone tumor in both adolescents and children. Early tumor detection is key to ensuring effective treatment. Serum marker discovery and validation for pediatric...

    Authors: Yulia A Savitskaya, Genaro Rico-Martínez, Luis Miguel Linares-González, Ernesto Andrés Delgado-Cedillo, René Téllez-Gastelum, Alfonso Benito Alfaro-Rodríguez, Antonio Redón-Tavera and José Clemente Ibarra-Ponce de León
    Citation: Clinical Sarcoma Research 2012 2:9
  23. Ewing sarcoma patients have a poor prognosis despite multimodal therapy. Integration of combination immunotherapeutic strategies into first-/second-line regimens represents promising treatment options, particu...

    Authors: Dagmar Berghuis, Marco W Schilham, Hanneke I Vos, Susy J Santos, Stephan Kloess, Emilie P Buddingh', R Maarten Egeler, Pancras CW Hogendoorn and Arjan C Lankester
    Citation: Clinical Sarcoma Research 2012 2:8
  24. Ewing Sarcoma is the second most common primary bone sarcoma with 900 new diagnoses per year in Europe (EU27). It has a poor survival rate in the face of metastatic disease, with no more than 10% survival of t...

    Authors: Annmeik M van Maldegem, Pancras CW Hogendoorn and Andrew B Hassan
    Citation: Clinical Sarcoma Research 2012 2:7
  25. High grade primary bone sarcomas are rare cancers that affect mostly children and young adults. Osteosarcoma and Ewing sarcoma are the most common histological subtypes in this age group, with current multimod...

    Authors: Annemiek M van Maldegem, Aparna Bhosale, Hans J Gelderblom, Pancras CW Hogendoorn and Andrew B Hassan
    Citation: Clinical Sarcoma Research 2012 2:5
  26. Dermatofibrosarcoma protuberans (DFSP) is a relatively common soft-tissue tumor. A more aggressive appearing fibrosarcoma may arise in DFSP, changing its biological behavior. CD34 and apolipoprotein-D are high...

    Authors: Emanuela Palmerini, Marco Gambarotti, Eric L Staals, Licciana Zanella, Gabriela Sieberova, Alessandra Longhi, Marilena Cesari, Stefano Bonarelli, Piero Picci, Pietro Ruggieri, Marco Alberghini and Stefano Ferrari
    Citation: Clinical Sarcoma Research 2012 2:4
  27. Desmoplastic small round cell tumour is a rare malignant tumour with a male to female ratio of 4:1. It manifests mostly at serosal sites. Here we present a case of a 28-year-old male patient, who presented wit...

    Authors: Vincent PM Cliteur, Károly Szuhai, Hans J Baelde, Jurriaan van Dam, Hans Gelderblom and Pancras CW Hogendoorn
    Citation: Clinical Sarcoma Research 2012 2:3
  28. Myxoid liposarcoma (MLS) is a soft tissue sarcoma with adipocytic differentiation characterized by a unique chromosome rearrangement, t(12;16)(q13;p11). The exact efficacy of chemotherapy in MLS has not been c...

    Authors: Daniela Katz, Piyaporn Boonsirikamchai, Haeson Choi, Alexander J Lazar, Wei-Lein Wang, Lianchun Xiao, Min S Park, Vinod Ravi, Robert S Benjamin and Dejka M Araujo
    Citation: Clinical Sarcoma Research 2012 2:2
  29. The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a seri...

    Authors: Fredrik Mertens, Salvatore Romeo, Judith VMG Bovée, Roberto Tirabosco, Nick Athanasou, Marco Alberghini, Pancras CW Hogendoorn, Angelo P Dei Tos, Raf Sciot, Henryk A Domanski, Kristina Åström, Nils Mandahl and Maria Debiec-Rychter
    Citation: Clinical Sarcoma Research 2011 1:10
  30. A 35-year-old female presented with pain and swelling of the distal left radius. A diagnosis of Ewing sarcoma was made and she underwent neoadjuvant chemotherapy and surgery. Macroscopic viable areas remained ...

    Authors: Noemie Vanel, Victoire Vierling, Jennifer Kreshak, Marco Gambarotti, Stefania Cocchi, Cristina Tranfaglia and Daniel Vanel
    Citation: Clinical Sarcoma Research 2011 1:9
  31. Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in lipos...

    Authors: Eva W Stratford, Russell Castro, Anna Wennerstrøm, Ruth Holm, Else Munthe, Silje Lauvrak, Bodil Bjerkehagen and Ola Myklebost
    Citation: Clinical Sarcoma Research 2011 1:8
  32. Leiomyosarcoma of deep soft tissues of the extremities is a rare malignant tumour treated primarily by surgery. The incidence of local recurrence and lymph node metastasis is uncertain and it is not known whet...

    Authors: Michael J Lamyman, Henk P Giele, Paul Critchley, Duncan Whitwell, Max Gibbons and Nicholas A Athanasou
    Citation: Clinical Sarcoma Research 2011 1:7
  33. Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and diffe...

    Authors: Danielle Meijer, Hans Gelderblom, Marcel Karperien, Anne-Marie Cleton-Jansen, Pancras CW Hogendoorn and Judith VMG Bovée
    Citation: Clinical Sarcoma Research 2011 1:5
  34. Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosi...

    Authors: Barbara Dewaele, Francesca Maggiani, Giuseppe Floris, Michèle Ampe, Vanessa Vanspauwen, Agnieszka Wozniak, Maria Debiec-Rychter and Raf Sciot
    Citation: Clinical Sarcoma Research 2011 1:4
  35. Parosteal osteosarcoma is a well-differentiated variant of osteosarcoma that affects the surface of the bone. The imaging pattern is very typical. We report two cases mimicking an osteochondroma, radiologicall...

    Authors: Zafiria G Papathanassiou, Marco Alberghini, Philippe Thiesse, Marco Gambarotti, Giuseppe Bianchi, Cristina Tranfaglia and Daniel Vanel
    Citation: Clinical Sarcoma Research 2011 1:2
  36. Welcome to Clinical Sarcoma Research a new open access, online medical journal providing a forum for clinical knowledge on rare solid cancers - sarcomas. We believe there is a vacuum, which this effort may hope t...

    Authors: Paolo G Casali and Angelo P Dei Tos
    Citation: Clinical Sarcoma Research 2011 1:1