The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a seri...
Authors: Fredrik Mertens, Salvatore Romeo, Judith VMG Bovée, Roberto Tirabosco, Nick Athanasou, Marco Alberghini, Pancras CW Hogendoorn, Angelo P Dei Tos, Raf Sciot, Henryk A Domanski, Kristina Åström, Nils Mandahl and Maria Debiec-Rychter
A 35-year-old female presented with pain and swelling of the distal left radius. A diagnosis of Ewing sarcoma was made and she underwent neoadjuvant chemotherapy and surgery. Macroscopic viable areas remained ...
Authors: Noemie Vanel, Victoire Vierling, Jennifer Kreshak, Marco Gambarotti, Stefania Cocchi, Cristina Tranfaglia and Daniel Vanel
Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in lipos...
Authors: Eva W Stratford, Russell Castro, Anna Wennerstrøm, Ruth Holm, Else Munthe, Silje Lauvrak, Bodil Bjerkehagen and Ola Myklebost
Leiomyosarcoma of deep soft tissues of the extremities is a rare malignant tumour treated primarily by surgery. The incidence of local recurrence and lymph node metastasis is uncertain and it is not known whet...
Authors: Michael J Lamyman, Henk P Giele, Paul Critchley, Duncan Whitwell, Max Gibbons and Nicholas A Athanasou
This review is intended to provide histopathologists with guidelines for clinical assessment, specimen handling and diagnostic reporting of benign and malignant primary bone tumours. Information from radiology...
Authors: D Charles Mangham and Nicholas A Athanasou
Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and diffe...
Authors: Danielle Meijer, Hans Gelderblom, Marcel Karperien, Anne-Marie Cleton-Jansen, Pancras CW Hogendoorn and Judith VMG Bovée
Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosi...
Authors: Barbara Dewaele, Francesca Maggiani, Giuseppe Floris, Michèle Ampe, Vanessa Vanspauwen, Agnieszka Wozniak, Maria Debiec-Rychter and Raf Sciot
Parosteal osteosarcoma is a well-differentiated variant of osteosarcoma that affects the surface of the bone. The imaging pattern is very typical. We report two cases mimicking an osteochondroma, radiologicall...
Authors: Zafiria G Papathanassiou, Marco Alberghini, Philippe Thiesse, Marco Gambarotti, Giuseppe Bianchi, Cristina Tranfaglia and Daniel Vanel
Welcome to Clinical Sarcoma Research a new open access, online medical journal providing a forum for clinical knowledge on rare solid cancers - sarcomas. We believe there is a vacuum, which this effort may hope t...
