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  1. Methodology

    How a Clinical Trial Unit can improve independent clinical research in rare tumors: the Italian Sarcoma Group experience

    The Italian Sarcoma Group (ISG) is a nonprofit group of professionals established in 1997 aimed to improve the quality of care and promote the independent research in sarcomas. The increased regulatory require...

    Emanuela Marchesi, Celeste Cagnazzo, Irene Quattrini, Martina Piccinni Leopardi, Chiara Villa, Giovanni Grignani, Lorenzo D’Ambrosio, Silvia Stacchiotti, Paolo Giovanni Casali and Piero Picci

    Clinical Sarcoma Research 2017 7:4

    Published on: 28 February 2017

  2. Research

    Osteosarcoma follow-up: chest X-ray or computed tomography?

    In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a valid...

    Anna Paioli, Michele Rocca, Luca Cevolani, Eugenio Rimondi, Daniel Vanel, Emanuela Palmerini, Marilena Cesari, Alessandra Longhi, Abate Massimo Eraldo, Emanuela Marchesi, Piero Picci and Stefano Ferrari

    Clinical Sarcoma Research 2017 7:3

    Published on: 14 February 2017

  3. Research

    Central venous access related adverse events after trabectedin infusions in soft tissue sarcoma patients; experience and management in a nationwide multi-center study

    Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access devices (VAD), such as subcutaneous ports with tunneled ...

    Michiel C. Verboom, Jan Ouwerkerk, Neeltje Steeghs, Jacob Lutjeboer, J. Martijn Kerst, Winette T. A. van der Graaf, Anna K. L. Reyners, Stefan Sleijfer and Hans Gelderblom

    Clinical Sarcoma Research 2017 7:2

    Published on: 31 January 2017

  4. Case report

    Radiotherapy in the management of gist: state of the art and new potential scenarios

    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable...

    L. Gatto, M. Nannini, M. Saponara, V. Di Scioscio, G. Beltramo, G. P. Frezza, G. Ercolani, A. D. Pinna, A. Astolfi, M. Urbini, G. Brandi, G. Biasco and M. A. Pantaleo

    Clinical Sarcoma Research 2017 7:1

    Published on: 10 January 2017

  5. Research

    Response to anti-PD1 therapy with nivolumab in metastatic sarcomas

    Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted antibodies has recently emerged as an effective anticancer strategy in multiple malignancies. Sarcomas are a heterogeneous group of diseas...

    L. Paoluzzi, A. Cacavio, M. Ghesani, A. Karambelkar, A. Rapkiewicz, J. Weber and G. Rosen

    Clinical Sarcoma Research 2016 6:24

    Published on: 30 December 2016

  6. Case report

    Metastatic meningioma presenting as a malignant soft tissue tumour

    Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

    Catherine McCarthy, Monika Hofer, Marianna Vlychou, Robar Khundkar, Paul Critchley, Simon Cudlip, Olaf Ansorge and Nick A. Athanasou

    Clinical Sarcoma Research 2016 6:23

    Published on: 30 December 2016

  7. Research

    Clinical implications of repeated drug monitoring of imatinib in patients with metastatic gastrointestinal stromal tumour

    Imatinib mesylate (IM) is the preferred treatment for the majority of patients with metastatic gastrointestinal stromal tumour (GIST). Low trough IM concentration (Cmin) values have been associated with poor clin...

    Ivar Hompland, Øyvind Sverre Bruland, Kumari Ubhayasekhera, Jonas Bergquist and Kjetil Boye

    Clinical Sarcoma Research 2016 6:21

    Published on: 15 December 2016

  8. Case report

    Pazopanib: a novel treatment option for aggressive fibromatosis

    Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resectio...

    Gulcan Bulut, Anil Ozluk, Atike Pınar Erdogan, Ruchan Uslu, Nevra Elmas and Burcak Karaca

    Clinical Sarcoma Research 2016 6:22

    Published on: 1 December 2016

  9. Review

    UK guidelines for the management of soft tissue sarcomas

    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence...

    Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan and Ian Judson

    Clinical Sarcoma Research 2016 6:20

    Published on: 15 November 2016

  10. Research

    Outcome and the effect of age and socioeconomic status in 1318 patients with synovial sarcoma in the English National Cancer Registry: 1985–2009

    The role of age as a prognostic factor has been examined in single institutional studies and in larger data sets from the SEER database, showing a survival advantage for younger versus adult patients with syno...

    Bernadette Brennan, Charles Stiller, Robert Grimer, Nicola Dennis, John Broggio and Matthew Francis

    Clinical Sarcoma Research 2016 6:18

    Published on: 14 October 2016

  11. Research

    High nuclear expression of proteasome activator complex subunit 1 predicts poor survival in soft tissue leiomyosarcomas

    Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is invol...

    Sha Lou, Arjen H. G. Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A. McDonnell and Judith V. M. G. Bovée

    Clinical Sarcoma Research 2016 6:17

    Published on: 1 October 2016

  12. Review

    Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone

    Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosum...

    Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas and Piotr Rutkowski

    Clinical Sarcoma Research 2016 6:15

    Published on: 14 September 2016

  13. Case Report

    Solitary fibrous tumour presenting with a single bone metastasis: report of six cases and literature review

    Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of di...

    Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali and Silvia Stacchiotti

    Clinical Sarcoma Research 2016 6:16

    Published on: 1 September 2016

  14. Research

    Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours

    A chronic inflammatory cell infiltrate is commonly seen in response to primary malignant tumours of bone. This is known to contain tumour-associated macrophages (TAMs) and lymphocytes; dendritic cells (DCs) an...

    Y. Inagaki, E. Hookway, K. A. Williams, A. B. Hassan, U. Oppermann, Y. Tanaka, E. Soilleux and N. A. Athanasou

    Clinical Sarcoma Research 2016 6:13

    Published on: 1 August 2016

  15. Research

    Predictors of survival in patients with sarcoma admitted to the intensive care unit

    Advances in treatment of sarcoma patients has prolonged survival but has led to increased disease- or treatment-related complications resulting in greater number of admissions to the intensive care unit (ICU)....

    Rohan Gupta, Neda Heshami, Chouhan Jay, Naveen Ramesh, Juhee Song, Xiudong Lei, Erfe Jean Rose, Kristen Carter, Dejka M. Araujo, Robert S. Benjamin, Shreyaskumar Patel, Joseph L. Nates and Vinod Ravi

    Clinical Sarcoma Research 2016 6:12

    Published on: 19 July 2016

  16. Research

    Patterns of care for patients with advanced soft tissue sarcoma: experience from Australian sarcoma services

    There is a paucity of data on the current management of patients with advanced soft tissue sarcoma (STS) in the Australian health care setting. This study utilised the Australian sarcoma database to evaluate t...

    Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley and Jayesh Desai

    Clinical Sarcoma Research 2016 6:11

    Published on: 11 July 2016

  17. Research

    Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study

    Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon...

    Joan Maurel, Antonio López-Pousa, Silvia Calabuig, Silvia Bagué, Xavier Garcia del Muro, Xavier Sanjuan, Jordi Rubió-Casadevall, Miriam Cuatrecasas, Javier Martinez-Trufero, Carlos Horndler, Joaquin Fra, Claudia Valverde, Andrés Redondo, Andrés Poveda, Isabel Sevilla, Nuria Lainez…

    Clinical Sarcoma Research 2016 6:10

    Published on: 29 June 2016

  18. Research

    A Korean single-center, real-world, retrospective study of first-line weekly paclitaxel in patients with metastatic angiosarcoma

    Angiosarcoma is a rare subgroup of soft tissue sarcomas associated with poor prognosis, but paclitaxel has been shown to be active in pretreated metastatic disease. We investigated the efficacy and safety of w...

    Seonggyu Byeon, Haa-Na Song, Hee Kyung Kim, Jun Soo Ham, Su Jin Lee, Jeeyun Lee and Se Hoon Park

    Clinical Sarcoma Research 2016 6:8

    Published on: 5 May 2016

  19. Review

    UK guidelines for the management of bone sarcomas

    This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommend...

    Craig Gerrand, Nick Athanasou, Bernadette Brennan, Robert Grimer, Ian Judson, Bruce Morland, David Peake, Beatrice Seddon and Jeremy Whelan

    Clinical Sarcoma Research 2016 6:7

    Published on: 4 May 2016

  20. Case Report

    Proof of principle for bevacizumab activity in desmoid-type fibromatosis

    Desmoid-type fibromatosis (DF) is a rare disease, which often occurs in young adults. Medical treatment is an important option in the treatment algorithm of DF. Different chemotherapeutic regimens showed clini...

    Viktor Grünwald, Florian Länger, H. J. Raatschen and Andreas Beilken

    Clinical Sarcoma Research 2016 6:5

    Published on: 4 April 2016

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