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Table 1 Pathologic description of chordoma cases and results summary

From: Frequent activation of EGFR in advanced chordomas

Cases Gender Age Tumor status Site Immuno FISH Proteome profiler array TK
Mut
Western TK aCGH
      EGFR HER2 EGFR HER2 PDGFRB/CSF1R PTEN P-EGFR P-PDGFRB   EGFR PDGFRB  
1a F 56 P Spinal 1+ neg dis. dis. polys. nd nd nd nd nd nd nd
1b    R Spinal neg nd dis. dis. polys. nd weak weak nd nd nd nd
2a M 33 R Spinal 1+ nd dis. dis. polys. nd nd nd nd nd nd nd
2b    M   3+ nd dis. dis. polys. nd nd nd neg E E nd
3 F 43 R Spinal 3+ neg polys. dis. dis. dis. strong weak neg nd nd table 2
4a M 62 P Spinal neg nd dis. dis. dis. dis. nd nd nd nd nd nd
4b    M   2+ nd polys. dis. polys. monos. interm weak neg E neg table 2
5 F 75 R Sacrum 3+ neg polys. polys. polys. polys. nd nd neg E/P E table 2
6 M 60 R Clivus 3+ nd dis. monos. dis. dis. strong interm. nd nd nd nd
7a F 62 P Sacrum neg nd polys. dis. dis. dis. nd nd nd nd nd nd
7b    R Sacrum 2+ nd polys. monos. dis. monos. nd nd neg E/P E table 2
8 M 36 P Clivus neg nd dis. dis. dis. nd nd nd nd nd nd nd
9 M 52 R Coccyx 1+ 1+ monos. dis. dis. dis. nd nd neg E/P E table 2
10a F 41 P Spinal neg nd polys. dis. loss dis. nd nd nd nd nd nd
10b    P Spinal neg nd polys. dis. loss monos. nd nd neg neg E/P table 2
10c    R Spinal neg nd polys. dis. polys. nd nd nd nd nd nd nd
11 F 54 P Cervical 2+ nd polys. dis. dis. nd strong weak nd nd nd nd
12a M 55 P Sacrum 3+ neg l.l.amp. dis. dis. monos. nd nd neg nd nd nd
12b    M   3+ 2+ h.l.amp. dis. polys. nd strong weak nd E/P E nd
13 M 80 R Coccyx 2+ nd polys. polys. polys. polys. interm weak neg nd nd table 2
14 F 60 R Sacrum 1+ nd dis. polys. dis. monos. nd nd neg E/P E table 2
15a F 73 P Spinal neg nd dis. dis. dis. monos. nd nd neg nd nd table 2
15b    R Spinal neg nd polys. polys. polys. nd nd nd nd E E nd
16 M 84 R Sacrum 1+ neg dis. dis. dis. dis. nd nd neg nd nd table 2
17a F 58 P Sacrum 2+ 1+ polys. dis. dis. nd strong interm. neg nd nd table 2
17b    R Sacrum 3+ neg polys. dis. dis. nd nd nd nd nd nd nd
18 F 57 P Sacrum 3+ neg polys. dis. dis. dis. strong weak nd nd nd nd
19 M 84 P Lumbal 1+ nd dis. monos. dis. nd nd nd nd nd nd nd
20 M 81 P Sacrum 3+ neg l.l.amp. dis. polys. nd strong weak nd nd nd nd
21 F 67 P Sacrum 1+ 1+ h.l.amp. dis. dis. nd interm weak nd nd nd nd
22 F 47 P Sacrum 1+ nd dis. dis. dis. nd weak weak nd nd nd nd
23 M 48 P Spinal nd nd dis. dis. dis. nd nd nd nd nd nd nd
24 F 60 R Clivus/nc 3+ nd polys. polys. polys. polys. nd nd nd nd nd nd
25 F 60 R Sacrum neg nd monos. dis. nd nd nd nd nd nd nd nd
26 M 80 M   nd nd polys. polys. polys. loss nd nd nd nd nd nd
27 M 48 P Sacrum 1+ nd dis. dis. nd nd nd nd nd nd nd nd
28 F 18 P Spinal nd nd dis. dis. nd nd nd nd nd nd nd nd
29 M 37 P Spinal 3+ neg dis. dis. nd nd nd nd nd nd nd nd
30a M 42 P Coccyx neg neg monos. dis. nd nd nd nd nd nd nd nd
30b   58 R Sacrum 2+ neg monos. dis. nd nd nd nd nd nd nd nd
31a F 60 P Sacrum neg 1+ polys. dis. nd nd nd nd nd nd nd nd
31b    R Ilium neg nd polys. dis. nd nd nd nd nd nd nd nd
  1. TK Mut., Tyrosine Kinase Mutations; P, primary; R, recurrence; M, metastasis; nc, nasal cavity; neg, negative; l.l.amp., low level amplification; h.l.amp., high level amplification;
  2. polys., polysomy; dis., disomy; monos., monosomy; nd, not done; interm, intermediate; E, expressed; P, phosphorylated.