Frequent activation of EGFR in advanced chordomas

Dewaele, Barbara; Maggiani, Francesca; Floris, Giuseppe; Ampe, Michèle; Vanspauwen, Vanessa; Wozniak, Agnieszka; Debiec-Rychter, Maria; Sciot, Raf

doi:10.1186/2045-3329-1-4

Clinical Sarcoma Research

Table 1 Pathologic description of chordoma cases and results summary

From: Frequent activation of EGFR in advanced chordomas

Cases	Gender	Age	Tumor status	Site	Immuno		FISH				Proteome profiler array		TK Mut	Western		TK aCGH
					EGFR	HER2	EGFR	HER2	PDGFRB/CSF1R	PTEN	P-EGFR	P-PDGFRB		EGFR	PDGFRB
1a	F	56	P	Spinal	1+	neg	dis.	dis.	polys.	nd	nd	nd	nd	nd	nd	nd
1b			R	Spinal	neg	nd	dis.	dis.	polys.	nd	weak	weak	nd	nd	nd	nd
2a	M	33	R	Spinal	1+	nd	dis.	dis.	polys.	nd	nd	nd	nd	nd	nd	nd
2b			M		3+	nd	dis.	dis.	polys.	nd	nd	nd	neg	E	E	nd
3	F	43	R	Spinal	3+	neg	polys.	dis.	dis.	dis.	strong	weak	neg	nd	nd	table 2
4a	M	62	P	Spinal	neg	nd	dis.	dis.	dis.	dis.	nd	nd	nd	nd	nd	nd
4b			M		2+	nd	polys.	dis.	polys.	monos.	interm	weak	neg	E	neg	table 2
5	F	75	R	Sacrum	3+	neg	polys.	polys.	polys.	polys.	nd	nd	neg	E/P	E	table 2
6	M	60	R	Clivus	3+	nd	dis.	monos.	dis.	dis.	strong	interm.	nd	nd	nd	nd
7a	F	62	P	Sacrum	neg	nd	polys.	dis.	dis.	dis.	nd	nd	nd	nd	nd	nd
7b			R	Sacrum	2+	nd	polys.	monos.	dis.	monos.	nd	nd	neg	E/P	E	table 2
8	M	36	P	Clivus	neg	nd	dis.	dis.	dis.	nd	nd	nd	nd	nd	nd	nd
9	M	52	R	Coccyx	1+	1+	monos.	dis.	dis.	dis.	nd	nd	neg	E/P	E	table 2
10a	F	41	P	Spinal	neg	nd	polys.	dis.	loss	dis.	nd	nd	nd	nd	nd	nd
10b			P	Spinal	neg	nd	polys.	dis.	loss	monos.	nd	nd	neg	neg	E/P	table 2
10c			R	Spinal	neg	nd	polys.	dis.	polys.	nd	nd	nd	nd	nd	nd	nd
11	F	54	P	Cervical	2+	nd	polys.	dis.	dis.	nd	strong	weak	nd	nd	nd	nd
12a	M	55	P	Sacrum	3+	neg	l.l.amp.	dis.	dis.	monos.	nd	nd	neg	nd	nd	nd
12b			M		3+	2+	h.l.amp.	dis.	polys.	nd	strong	weak	nd	E/P	E	nd
13	M	80	R	Coccyx	2+	nd	polys.	polys.	polys.	polys.	interm	weak	neg	nd	nd	table 2
14	F	60	R	Sacrum	1+	nd	dis.	polys.	dis.	monos.	nd	nd	neg	E/P	E	table 2
15a	F	73	P	Spinal	neg	nd	dis.	dis.	dis.	monos.	nd	nd	neg	nd	nd	table 2
15b			R	Spinal	neg	nd	polys.	polys.	polys.	nd	nd	nd	nd	E	E	nd
16	M	84	R	Sacrum	1+	neg	dis.	dis.	dis.	dis.	nd	nd	neg	nd	nd	table 2
17a	F	58	P	Sacrum	2+	1+	polys.	dis.	dis.	nd	strong	interm.	neg	nd	nd	table 2
17b			R	Sacrum	3+	neg	polys.	dis.	dis.	nd	nd	nd	nd	nd	nd	nd
18	F	57	P	Sacrum	3+	neg	polys.	dis.	dis.	dis.	strong	weak	nd	nd	nd	nd
19	M	84	P	Lumbal	1+	nd	dis.	monos.	dis.	nd	nd	nd	nd	nd	nd	nd
20	M	81	P	Sacrum	3+	neg	l.l.amp.	dis.	polys.	nd	strong	weak	nd	nd	nd	nd
21	F	67	P	Sacrum	1+	1+	h.l.amp.	dis.	dis.	nd	interm	weak	nd	nd	nd	nd
22	F	47	P	Sacrum	1+	nd	dis.	dis.	dis.	nd	weak	weak	nd	nd	nd	nd
23	M	48	P	Spinal	nd	nd	dis.	dis.	dis.	nd	nd	nd	nd	nd	nd	nd
24	F	60	R	Clivus/nc	3+	nd	polys.	polys.	polys.	polys.	nd	nd	nd	nd	nd	nd
25	F	60	R	Sacrum	neg	nd	monos.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
26	M	80	M		nd	nd	polys.	polys.	polys.	loss	nd	nd	nd	nd	nd	nd
27	M	48	P	Sacrum	1+	nd	dis.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
28	F	18	P	Spinal	nd	nd	dis.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
29	M	37	P	Spinal	3+	neg	dis.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
30a	M	42	P	Coccyx	neg	neg	monos.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
30b		58	R	Sacrum	2+	neg	monos.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
31a	F	60	P	Sacrum	neg	1+	polys.	dis.	nd	nd	nd	nd	nd	nd	nd	nd
31b			R	Ilium	neg	nd	polys.	dis.	nd	nd	nd	nd	nd	nd	nd	nd

TK Mut., Tyrosine Kinase Mutations; P, primary; R, recurrence; M, metastasis; nc, nasal cavity; neg, negative; l.l.amp., low level amplification; h.l.amp., high level amplification;
polys., polysomy; dis., disomy; monos., monosomy; nd, not done; interm, intermediate; E, expressed; P, phosphorylated.

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