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Clinical Sarcoma Research

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  1. Content type: Research

    Treatment of giant cell tumour of bone (GCTB) of the distal radius/ulna poses a surgical challenge, as complex reconstructive surgery may be required. This study evaluates the clinical, radiological and pathol...

    Authors: Catherine L. McCarthy, Christopher L. M. H. Gibbons, Kevin M. Bradley, A. Bass Hassan, Henk Giele and Nicholas A. Athanasou

    Citation: Clinical Sarcoma Research 2017 7:19

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  2. Content type: Research

    Since treatment patterns in metastatic soft tissue sarcoma (mSTS) have not been studied subsequent to US approval of pazopanib in 2012, this study sought to examine mSTS treatment patterns by line of therapy, ...

    Authors: Victor M. Villalobos, Stacey DaCosta Byfield, Sameer R. Ghate and Oluwakayode Adejoro

    Citation: Clinical Sarcoma Research 2017 7:18

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  3. Content type: Research

    VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is ab...

    Authors: E. S. Hookway, Z. Orosz, Y. Uchihara, A. Grigoriadis, A. B. Hassan, U. Oppermann and N. A. Athanasou

    Citation: Clinical Sarcoma Research 2017 7:17

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  4. Content type: Research

    We report on the activity of anthracycline-based and high-dose prolonged-infusion ifosfamide chemotherapy in a retrospective series of patients affected by advanced myxofibrosarcoma treated at Istituto Naziona...

    Authors: Vittoria Colia, Marco Fiore, Salvatore Provenzano, Elena Fumagalli, Rossella Bertulli, Carlo Morosi, Angelo P. Dei Tos, Marta Barisella, Alessandro Gronchi, Paolo G. Casali and Roberta Sanfilippo

    Citation: Clinical Sarcoma Research 2017 7:16

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  5. Content type: Research

    Radiation induced angiosarcoma (RIAS) of the breast is a rare and aggressive complication of radiotherapy. Due to the rarity of this disease, much of the evidence for its management is based on case reports or...

    Authors: R. B. Cohen-Hallaleh, H. G. Smith, R. C. Smith, G. F. Stamp, O. Al-Muderis, K. Thway, A. Miah, K. Khabra, I. Judson, R. Jones, C. Benson and A. J. Hayes

    Citation: Clinical Sarcoma Research 2017 7:15

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  6. Content type: Case report

    Primary pulmonary artery sarcomas are rare malignant vascular tumors and carry a very poor prognosis. Due to overlapping clinical and radiological features, the differentiation between pulmonary artery thrombo...

    Authors: Abhishek Mahajan, Bharat Rekhi, Siddhartha Laskar, Jyoti Bajpai, Lekshmy Jayasree and Meenakshi H. Thakur

    Citation: Clinical Sarcoma Research 2017 7:13

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  7. Content type: Research

    PRAME (preferentially expressed antigen in melanoma), a member of the cancer-testis antigen family, has been shown to have increased expression in solid tumors, including sarcoma, and PRAME-specific therapies ...

    Authors: Jason Roszik, Wei-Lien Wang, John A. Livingston, Christina L. Roland, Vinod Ravi, Cassian Yee, Patrick Hwu, Andrew Futreal, Alexander J. Lazar, Shreyaskumar R. Patel and Anthony P. Conley

    Citation: Clinical Sarcoma Research 2017 7:11

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  8. Content type: Case Report

    Leiomyosarcoma of the head and neck is a rare cancer with high local aggressiveness. Radical surgery and adjuvant treatment offer the best chance for cure, nonetheless 5-years recurrence rate remains high. Des...

    Authors: Enrico Pinotti, Marta Sandini, Simone Famularo, Marta Jaconi, Fabrizio Romano, Luca Nespoli and Luca Gianotti

    Citation: Clinical Sarcoma Research 2017 7:12

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  9. Content type: Research

    Desmoplastic small round cell tumor (DSRCT) is a very rare mesenchymal tumor that mainly affects teenagers and young adults with a mean age at diagnosis around 20–25 years. Although initial management still ne...

    Authors: Sarah Bétrian, Christophe Bergeron, Jean-Yves Blay, Emmanuelle Bompas, Philippe A. Cassier, Laure Chevallier, Jérome Fayette, Magali Girodet, Cécile Guillemet, Axel Le Cesne, Perrine Marec-Berard, Isabelle Ray-Coquard and Christine Chevreau

    Citation: Clinical Sarcoma Research 2017 7:10

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  10. Content type: Research

    Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentat...

    Authors: Christian Koelsche, Daniel Schrimpf, Lars Tharun, Eva Roth, Dominik Sturm, David T. W. Jones, Eva-Kristin Renker, Martin Sill, Annika Baude, Felix Sahm, David Capper, Melanie Bewerunge-Hudler, Wolfgang Hartmann, Andreas E. Kulozik, Iver Petersen, Uta Flucke…

    Citation: Clinical Sarcoma Research 2017 7:9

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  11. Content type: Research

    Mutations in isocitrate dehydrogenase (IDH)1 or -2 are found in ~50% of conventional central chondrosarcomas and in up to 87% of their assumed benign precursors enchondromas. The mutant enzyme acquires the activi...

    Authors: Arjen H. G. Cleven, Johnny Suijker, Georgios Agrogiannis, Inge H. Briaire-de Bruijn, Norma Frizzell, Attje S. Hoekstra, Pauline M. Wijers-Koster, Anne-Marie Cleton-Jansen and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2017 7:8

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  12. Content type: Review

    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues. Gastrointestinal stromal tumour (GIST) is the commonest STS and arises within the wall of the gastrointestinal (GI) tract. While most...

    Authors: Ian Judson, Ramesh Bulusu, Beatrice Seddon, Adam Dangoor, Newton Wong and Satvinder Mudan

    Citation: Clinical Sarcoma Research 2017 7:6

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  13. Content type: Methodology

    The Italian Sarcoma Group (ISG) is a nonprofit group of professionals established in 1997 aimed to improve the quality of care and promote the independent research in sarcomas. The increased regulatory require...

    Authors: Emanuela Marchesi, Celeste Cagnazzo, Irene Quattrini, Martina Piccinni Leopardi, Chiara Villa, Giovanni Grignani, Lorenzo D’Ambrosio, Silvia Stacchiotti, Paolo Giovanni Casali and Piero Picci

    Citation: Clinical Sarcoma Research 2017 7:4

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  14. Content type: Research

    In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a valid...

    Authors: Anna Paioli, Michele Rocca, Luca Cevolani, Eugenio Rimondi, Daniel Vanel, Emanuela Palmerini, Marilena Cesari, Alessandra Longhi, Abate Massimo Eraldo, Emanuela Marchesi, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2017 7:3

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    The Erratum to this article has been published in Clinical Sarcoma Research 2017 7:7

  15. Content type: Research

    Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access devices (VAD), such as subcutaneous ports with tunneled ...

    Authors: Michiel C. Verboom, Jan Ouwerkerk, Neeltje Steeghs, Jacob Lutjeboer, J. Martijn Kerst, Winette T. A. van der Graaf, Anna K. L. Reyners, Stefan Sleijfer and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2017 7:2

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  16. Content type: Case report

    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable...

    Authors: L. Gatto, M. Nannini, M. Saponara, V. Di Scioscio, G. Beltramo, G. P. Frezza, G. Ercolani, A. D. Pinna, A. Astolfi, M. Urbini, G. Brandi, G. Biasco and M. A. Pantaleo

    Citation: Clinical Sarcoma Research 2017 7:1

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  17. Content type: Case report

    Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

    Authors: Catherine McCarthy, Monika Hofer, Marianna Vlychou, Robar Khundkar, Paul Critchley, Simon Cudlip, Olaf Ansorge and Nick A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:23

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  18. Content type: Research

    Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted antibodies has recently emerged as an effective anticancer strategy in multiple malignancies. Sarcomas are a heterogeneous group of diseas...

    Authors: L. Paoluzzi, A. Cacavio, M. Ghesani, A. Karambelkar, A. Rapkiewicz, J. Weber and G. Rosen

    Citation: Clinical Sarcoma Research 2016 6:24

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  19. Content type: Research

    Imatinib mesylate (IM) is the preferred treatment for the majority of patients with metastatic gastrointestinal stromal tumour (GIST). Low trough IM concentration (Cmin) values have been associated with poor clin...

    Authors: Ivar Hompland, Øyvind Sverre Bruland, Kumari Ubhayasekhera, Jonas Bergquist and Kjetil Boye

    Citation: Clinical Sarcoma Research 2016 6:21

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  20. Content type: Case report

    Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resectio...

    Authors: Gulcan Bulut, Anil Ozluk, Atike Pınar Erdogan, Ruchan Uslu, Nevra Elmas and Burcak Karaca

    Citation: Clinical Sarcoma Research 2016 6:22

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  21. Content type: Review

    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence...

    Authors: Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2016 6:20

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  22. Content type: Case report

    Chordomas are rare malignant tumours of the axial skeleton and skull base supposed to arise from cellular remnants of the notochord. These tumours have the potential to metastasize (30–40 %), usually in the la...

    Authors: Astrid Lipplaa, Sander Dijkstra and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2016 6:19

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