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  1. Content type: Research

    Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, w...

    Authors: Jennifer M. Brown, Akiro Mantoku, Afsie Sabokbar, Udo Oppermann, A. Bass Hassan, Akiro Kudo and Nick Athanasou

    Citation: Clinical Sarcoma Research 2018 8:18

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  2. Content type: Case Report

    We studied two cases of rare fibrous bone tumors, namely desmoplastic fibroma (DF) and low-grade central osteosarcoma (LGCOS) resembling desmoplastic fibroma (DF-like LGCOS). As the clinical presentation, imag...

    Authors: Wangzhao Song, Eva van den Berg, Thomas C. Kwee, Paul C. Jutte, Anne-Marie Cleton-Jansen, Judith V. M. G. Bovée and Albert J. Suurmeijer

    Citation: Clinical Sarcoma Research 2018 8:16

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  3. Content type: Meeting Report

    This report summarizes the proceedings of the 4th European Bone Sarcoma Networking Meeting, held in London, England, on 21 June 2017. The meeting brought together scientific and clinical researchers and repres...

    Authors: Sandra J. Strauss, Jakob Anninga, Rubina Baglio, Daniel Baumhoer, Sam Behjati, Stefan Bielack, Kjetil Boye, Javier M. Broto, Anne-Marie Cleton-Jansen, Andrea Degasperi, Abigail Evans, Franca Fagioli, Marta Fiocco, Nathalie Gaspar, Dominique Heymann, Nadia Hindi…

    Citation: Clinical Sarcoma Research 2018 8:17

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  4. Content type: Case report

    Tenosynovial giant cell tumors (TGCTs) or giant cell tumors of tendon sheath are neoplasms that arise in the synovium. They can be categorized as nodular (localized) or diffuse type (D-TGCT). Historically, sur...

    Authors: Nicholas Giustini, Nicholas M. Bernthal, Susan V. Bukata and Arun S. Singh

    Citation: Clinical Sarcoma Research 2018 8:14

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  5. Content type: Research

    Induction chemotherapy by isolated limb perfusion (ILP) with melphalan and tumour necrosis factor-α is an effective strategy to facilitate limb-conserving surgery in locally advanced extremity sarcoma. In a co...

    Authors: Jens Jakob, Henry G. Smith, Michelle J. Wilkinson, Tim Pencavel, Aisha B. Miah, Joseph M. Thomas, Per-Ulf Tunn, Lothar R. Pilz, Dirk C. Strauss, Peter Hohenberger and Andrew J. Hayes

    Citation: Clinical Sarcoma Research 2018 8:12

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  6. Content type: Research

    Kaposi’s sarcoma is a low-grade mesenchymal angioproliferative tumor, most commonly observed in immunocompromised individuals, such as HIV-infected patients. Iatrogenic Kaposi’s sarcoma occurs in patients unde...

    Authors: Emilien Billon, Anne-Marie Stoppa, Lena Mescam, Massimo Bocci, Audrey Monneur, Delphine Perrot and François Bertucci

    Citation: Clinical Sarcoma Research 2018 8:11

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  7. Content type: Research

    Post-transplant smooth muscle tumors (PTSMTs) are rare mesenchymal neoplasms which occur after solid organ or haematopoietic stem cell transplantation. PTSMT typically consist of Epstein–Barr-virus (EBV)+ smoo...

    Authors: Kristin Teiken, Mark Kuehnel, Jan Rehkaemper, Hans Kreipe, Florian Laenger, Kais Hussein and Danny Jonigk

    Citation: Clinical Sarcoma Research 2018 8:10

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  8. Content type: Research

    One of the commonly used systemic agents for the treatment of aggressive fibromatosis is the anti-oestrogen drug tamoxifen. However, data on efficacy and optimum methods of response assessment are limited, con...

    Authors: M. Libertini, I. Mitra, W. T. A. van der Graaf, A. B. Miah, I. Judson, R. L. Jones, K. Thomas, E. Moskovic, Z. Szucs, C. Benson and C. Messiou

    Citation: Clinical Sarcoma Research 2018 8:13

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  9. Content type: Research

    To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histolo...

    Authors: Rohan C. Parikh, Maria Lorenzo, Lisa M. Hess, Sean D. Candrilli, Steven Nicol and James A. Kaye

    Citation: Clinical Sarcoma Research 2018 8:8

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  10. Content type: Research

    Soft tissue sarcomas (STS) are often treated with pre-operative radiation (RT), with or without chemotherapy, followed by wide local excision. Prognosis for these patients involves an interplay of tumor and pa...

    Authors: Nicholas P. Gannon, David M. King and Manpreet Bedi

    Citation: Clinical Sarcoma Research 2018 8:7

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  11. Content type: Research

    The use of 18F-FDG PET–CT (PET–CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET–CT in bone and soft tissue sarcoma with varied grade in a single multi-disci...

    Authors: Ruth E. Macpherson, Sarah Pratap, Helen Tyrrell, Mehrdad Khonsari, Shaun Wilson, Max Gibbons, Duncan Whitwell, Henk Giele, Paul Critchley, Lucy Cogswell, Sally Trent, Nick Athanasou, Kevin M. Bradley and A. Bassim Hassan

    Citation: Clinical Sarcoma Research 2018 8:9

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  12. Content type: Research

    Two national clinical trial groups, United Kingdom Children’s Cancer and Leukaemia Group (CCLG) and the German Paediatric Oncology and Haematology Group (GPOH) together undertook a randomised trial, EICESS-92,...

    Authors: Jeremy Whelan, Allan Hackshaw, Anne McTiernan, Robert Grimer, David Spooner, Jessica Bate, Andreas Ranft, Michael Paulussen, Herbert Juergens, Alan Craft and Ian Lewis

    Citation: Clinical Sarcoma Research 2018 8:6

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  13. Content type: Research

    Soft tissue and bone sarcoma represent a broad spectrum of different pathology and genetic variance. Current chemotherapy regimens are derived from randomised trials and represent empirical treatment. Chemosen...

    Authors: Nicholas Calvert, Jiansha Wu, Sophie Sneddon, Jennifer Woodhouse, Richard Carey-Smith, David Wood and Evan Ingley

    Citation: Clinical Sarcoma Research 2018 8:4

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  14. Content type: Research

    Retroperitoneal sarcomas (RPS) should be surgically managed in specialized sarcoma centers. However, it is not clearly demonstrated if clinical outcome is more influenced by Center Case Volume (CCV) or by Surg...

    Authors: Sergio Sandrucci, Agostino Ponzetti, Claudio Gianotti, Baudolino Mussa, Patrizia Lista, Giovanni Grignani, Marinella Mistrangelo, Oscar Bertetto, Daniela Di Cuonzo and Giovannino Ciccone

    Citation: Clinical Sarcoma Research 2018 8:3

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  15. Content type: Case report

    Papillary intralymphatic angioendothelioma (PILA) is a locally aggressive, rarely metastasizing vascular tumor, generally occurring in the soft tissues, with less than 40 cases described in the literature and ...

    Authors: Marco Gambarotti, Alberto Righi, Marta Sbaraglia, Giuseppe Bianchi, Piero Picci, Daniel Vanel and Angelo Paolo Dei Tos

    Citation: Clinical Sarcoma Research 2018 8:1

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  16. Content type: Case report

    Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain lineage and intermediate biological potential. It is more common in middle-aged men, usually arising from the deep tissues of the ...

    Authors: Salvatore Provenzano, Alessandra Raimondi, Rossella M. Bertulli, Vittoria Colia, Salvatore L. Renne, Paola Collini, Gianpaolo Dagrada, Dario Callegaro, Marco Fiore, Francesca G. Greco and Paolo G. Casali

    Citation: Clinical Sarcoma Research 2017 7:20

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  17. Content type: Research

    Treatment of giant cell tumour of bone (GCTB) of the distal radius/ulna poses a surgical challenge, as complex reconstructive surgery may be required. This study evaluates the clinical, radiological and pathol...

    Authors: Catherine L. McCarthy, Christopher L. M. H. Gibbons, Kevin M. Bradley, A. Bass Hassan, Henk Giele and Nicholas A. Athanasou

    Citation: Clinical Sarcoma Research 2017 7:19

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  18. Content type: Research

    Since treatment patterns in metastatic soft tissue sarcoma (mSTS) have not been studied subsequent to US approval of pazopanib in 2012, this study sought to examine mSTS treatment patterns by line of therapy, ...

    Authors: Victor M. Villalobos, Stacey DaCosta Byfield, Sameer R. Ghate and Oluwakayode Adejoro

    Citation: Clinical Sarcoma Research 2017 7:18

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  19. Content type: Research

    VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is ab...

    Authors: E. S. Hookway, Z. Orosz, Y. Uchihara, A. Grigoriadis, A. B. Hassan, U. Oppermann and N. A. Athanasou

    Citation: Clinical Sarcoma Research 2017 7:17

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  20. Content type: Research

    We report on the activity of anthracycline-based and high-dose prolonged-infusion ifosfamide chemotherapy in a retrospective series of patients affected by advanced myxofibrosarcoma treated at Istituto Naziona...

    Authors: Vittoria Colia, Marco Fiore, Salvatore Provenzano, Elena Fumagalli, Rossella Bertulli, Carlo Morosi, Angelo P. Dei Tos, Marta Barisella, Alessandro Gronchi, Paolo G. Casali and Roberta Sanfilippo

    Citation: Clinical Sarcoma Research 2017 7:16

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  21. Content type: Research

    Radiation induced angiosarcoma (RIAS) of the breast is a rare and aggressive complication of radiotherapy. Due to the rarity of this disease, much of the evidence for its management is based on case reports or...

    Authors: R. B. Cohen-Hallaleh, H. G. Smith, R. C. Smith, G. F. Stamp, O. Al-Muderis, K. Thway, A. Miah, K. Khabra, I. Judson, R. Jones, C. Benson and A. J. Hayes

    Citation: Clinical Sarcoma Research 2017 7:15

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  22. Content type: Case report

    Primary pulmonary artery sarcomas are rare malignant vascular tumors and carry a very poor prognosis. Due to overlapping clinical and radiological features, the differentiation between pulmonary artery thrombo...

    Authors: Abhishek Mahajan, Bharat Rekhi, Siddhartha Laskar, Jyoti Bajpai, Lekshmy Jayasree and Meenakshi H. Thakur

    Citation: Clinical Sarcoma Research 2017 7:13

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  23. Content type: Research

    PRAME (preferentially expressed antigen in melanoma), a member of the cancer-testis antigen family, has been shown to have increased expression in solid tumors, including sarcoma, and PRAME-specific therapies ...

    Authors: Jason Roszik, Wei-Lien Wang, John A. Livingston, Christina L. Roland, Vinod Ravi, Cassian Yee, Patrick Hwu, Andrew Futreal, Alexander J. Lazar, Shreyaskumar R. Patel and Anthony P. Conley

    Citation: Clinical Sarcoma Research 2017 7:11

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  24. Content type: Case Report

    Leiomyosarcoma of the head and neck is a rare cancer with high local aggressiveness. Radical surgery and adjuvant treatment offer the best chance for cure, nonetheless 5-years recurrence rate remains high. Des...

    Authors: Enrico Pinotti, Marta Sandini, Simone Famularo, Marta Jaconi, Fabrizio Romano, Luca Nespoli and Luca Gianotti

    Citation: Clinical Sarcoma Research 2017 7:12

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  25. Content type: Research

    Desmoplastic small round cell tumor (DSRCT) is a very rare mesenchymal tumor that mainly affects teenagers and young adults with a mean age at diagnosis around 20–25 years. Although initial management still ne...

    Authors: Sarah Bétrian, Christophe Bergeron, Jean-Yves Blay, Emmanuelle Bompas, Philippe A. Cassier, Laure Chevallier, Jérome Fayette, Magali Girodet, Cécile Guillemet, Axel Le Cesne, Perrine Marec-Berard, Isabelle Ray-Coquard and Christine Chevreau

    Citation: Clinical Sarcoma Research 2017 7:10

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  26. Content type: Research

    Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentat...

    Authors: Christian Koelsche, Daniel Schrimpf, Lars Tharun, Eva Roth, Dominik Sturm, David T. W. Jones, Eva-Kristin Renker, Martin Sill, Annika Baude, Felix Sahm, David Capper, Melanie Bewerunge-Hudler, Wolfgang Hartmann, Andreas E. Kulozik, Iver Petersen, Uta Flucke…

    Citation: Clinical Sarcoma Research 2017 7:9

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  27. Content type: Research

    Mutations in isocitrate dehydrogenase (IDH)1 or -2 are found in ~50% of conventional central chondrosarcomas and in up to 87% of their assumed benign precursors enchondromas. The mutant enzyme acquires the activi...

    Authors: Arjen H. G. Cleven, Johnny Suijker, Georgios Agrogiannis, Inge H. Briaire-de Bruijn, Norma Frizzell, Attje S. Hoekstra, Pauline M. Wijers-Koster, Anne-Marie Cleton-Jansen and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2017 7:8

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  28. Content type: Review

    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues. Gastrointestinal stromal tumour (GIST) is the commonest STS and arises within the wall of the gastrointestinal (GI) tract. While most...

    Authors: Ian Judson, Ramesh Bulusu, Beatrice Seddon, Adam Dangoor, Newton Wong and Satvinder Mudan

    Citation: Clinical Sarcoma Research 2017 7:6

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  29. Content type: Methodology

    The Italian Sarcoma Group (ISG) is a nonprofit group of professionals established in 1997 aimed to improve the quality of care and promote the independent research in sarcomas. The increased regulatory require...

    Authors: Emanuela Marchesi, Celeste Cagnazzo, Irene Quattrini, Martina Piccinni Leopardi, Chiara Villa, Giovanni Grignani, Lorenzo D’Ambrosio, Silvia Stacchiotti, Paolo Giovanni Casali and Piero Picci

    Citation: Clinical Sarcoma Research 2017 7:4

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  30. Content type: Research

    In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a valid...

    Authors: Anna Paioli, Michele Rocca, Luca Cevolani, Eugenio Rimondi, Daniel Vanel, Emanuela Palmerini, Marilena Cesari, Alessandra Longhi, Abate Massimo Eraldo, Emanuela Marchesi, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2017 7:3

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    The Erratum to this article has been published in Clinical Sarcoma Research 2017 7:7

  31. Content type: Research

    Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access devices (VAD), such as subcutaneous ports with tunneled ...

    Authors: Michiel C. Verboom, Jan Ouwerkerk, Neeltje Steeghs, Jacob Lutjeboer, J. Martijn Kerst, Winette T. A. van der Graaf, Anna K. L. Reyners, Stefan Sleijfer and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2017 7:2

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  32. Content type: Case report

    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable...

    Authors: L. Gatto, M. Nannini, M. Saponara, V. Di Scioscio, G. Beltramo, G. P. Frezza, G. Ercolani, A. D. Pinna, A. Astolfi, M. Urbini, G. Brandi, G. Biasco and M. A. Pantaleo

    Citation: Clinical Sarcoma Research 2017 7:1

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  33. Content type: Case report

    Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

    Authors: Catherine McCarthy, Monika Hofer, Marianna Vlychou, Robar Khundkar, Paul Critchley, Simon Cudlip, Olaf Ansorge and Nick A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:23

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  34. Content type: Research

    Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted antibodies has recently emerged as an effective anticancer strategy in multiple malignancies. Sarcomas are a heterogeneous group of diseas...

    Authors: L. Paoluzzi, A. Cacavio, M. Ghesani, A. Karambelkar, A. Rapkiewicz, J. Weber and G. Rosen

    Citation: Clinical Sarcoma Research 2016 6:24

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  35. Content type: Research

    Imatinib mesylate (IM) is the preferred treatment for the majority of patients with metastatic gastrointestinal stromal tumour (GIST). Low trough IM concentration (Cmin) values have been associated with poor clin...

    Authors: Ivar Hompland, Øyvind Sverre Bruland, Kumari Ubhayasekhera, Jonas Bergquist and Kjetil Boye

    Citation: Clinical Sarcoma Research 2016 6:21

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  36. Content type: Case report

    Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resectio...

    Authors: Gulcan Bulut, Anil Ozluk, Atike Pınar Erdogan, Ruchan Uslu, Nevra Elmas and Burcak Karaca

    Citation: Clinical Sarcoma Research 2016 6:22

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  37. Content type: Review

    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence...

    Authors: Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2016 6:20

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  38. Content type: Case report

    Chordomas are rare malignant tumours of the axial skeleton and skull base supposed to arise from cellular remnants of the notochord. These tumours have the potential to metastasize (30–40 %), usually in the la...

    Authors: Astrid Lipplaa, Sander Dijkstra and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2016 6:19

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  39. Content type: Research

    The role of age as a prognostic factor has been examined in single institutional studies and in larger data sets from the SEER database, showing a survival advantage for younger versus adult patients with syno...

    Authors: Bernadette Brennan, Charles Stiller, Robert Grimer, Nicola Dennis, John Broggio and Matthew Francis

    Citation: Clinical Sarcoma Research 2016 6:18

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  40. Content type: Research

    Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is invol...

    Authors: Sha Lou, Arjen H. G. Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A. McDonnell and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2016 6:17

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  41. Content type: Review

    Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosum...

    Authors: Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas and Piotr Rutkowski

    Citation: Clinical Sarcoma Research 2016 6:15

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  42. Content type: Case Report

    Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of di...

    Authors: Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2016 6:16

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